Rolf Bodmer

[The use of RNAi as a technique to study the functions of heart-related genes in Drosophila].

The bereft gene, a potential target of the neural selector gene cut, contributes to bristle morphogenesis.

MBLR, a new RING finger protein resembling mammalian Polycomb gene products, is regulated by cell cycle-dependent phosphorylation.

The patterns of wingless, decapentaplegic, and tinman position the Drosophila heart.

Transcriptional integration of competence modulated by mutual repression generates cell-type specificity within the cardiogenic mesoderm.

AmphiNk2-tin, an amphioxus homeobox gene expressed in myocardial progenitors: insights into evolution of the vertebrate heart.

Gata factor Pannier is required to establish competence for heart progenitor formation.

Myogenic cells fates are antagonized by Notch only in asymmetric lineages of the Drosophila heart, with or without cell division.

Dynamics of Cux2 expression suggests that an early pool of SVZ precursors is fated to become upper cortical layer neurons.

Screening assays for heart function mutants in Drosophila.

Drosophila, an emerging model for cardiac disease.

Insulin regulation of heart function in aging fruit flies.

Neuromancer Tbx20-related genes (H15/midline) promote cell fate specification and morphogenesis of the Drosophila heart.

Identification of genetic loci that interact with cut during Drosophila wing-margin development.

Embryonic even skipped-dependent muscle and heart cell fates are required for normal adult activity, heart function, and lifespan.

Slit and Robo control cardiac cell polarity and morphogenesis.

Hedgehog and RAS pathways cooperate in the anterior-posterior specification and positioning of cardiac progenitor cells.

Role of svp in Drosophila pericardial cell growth.

Images in cardiovascular medicine: in vivo imaging of the adult Drosophila melanogaster heart with real-time optical coherence tomography.

The ATP-sensitive potassium (KATP) channel-encoded dSUR gene is required for Drosophila heart function and is regulated by tinman.

Activated FOXO-mediated insulin resistance is blocked by reduction of TOR activity.

Antioxidants protect PINK1-dependent dopaminergic neurons in Drosophila.

Functional conservation of zinc-finger homeodomain gene zfh1/SIP1 in Drosophila heart development.

Cardioblast-intrinsic Tinman activity controls proper diversification and differentiation of myocardial cells in Drosophila.

Age-related cardiac disease model of Drosophila.

Drosophila aging 2005/06.

Age-related cardiac deterioration: insights from Drosophila.

Cardiac aging.

KCNQ potassium channel mutations cause cardiac arrhythmias in Drosophila that mimic the effects of aging.

Genetic control of heart function and aging in Drosophila.

Genetic variation for cardiac dysfunction in Drosophila.

Myosin transducer mutations differentially affect motor function, myofibril structure, and the performance of skeletal and cardiac muscles.

Drosophila aging 2006/2007.

Spatial specificity of mesodermal even-skipped expression relies on multiple repressor sites.

The Drosophila muscle LIM protein, Mlp84B, is essential for cardiac function.

ZNF418, a novel human KRAB/C2H2 zinc finger protein, suppresses MAPK signaling pathway.

Dystrophin deficiency in Drosophila reduces lifespan and causes a dilated cardiomyopathy phenotype.

Dispensable role of Drosophila ortholog of LRRK2 kinase activity in survival of dopaminergic neurons.

A novel human BTB-kelch protein KLHL31, strongly expressed in muscle and heart, inhibits transcriptional activities of TRE and SRE.

Transcription factor neuromancer/TBX20 is required for cardiac function in Drosophila with implications for human heart disease.

The Drosophila homolog of vertebrate Islet1 is a key component in early cardiogenesis.

Non-autonomous modulation of heart rhythm, contractility and morphology in adult fruit flies.

A new method for detection and quantification of heartbeat parameters in Drosophila, zebrafish, and embryonic mouse hearts.

Partial loss of GATA factor Pannier impairs adult heart function in Drosophila.

d4eBP acts downstream of both dTOR and dFoxo to modulate cardiac functional aging in Drosophila.

KBTBD7, a novel human BTB-kelch protein, activates transcriptional activities of SRE and AP-1.

Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies.

A global in vivo Drosophila RNAi screen identifies NOT3 as a conserved regulator of heart function.

SAMD4B, a novel SAM-containing protein, inhibits AP-1-, p53- and p21-mediated transcriptional activity.

Sestrins at the crossroad between stress and aging.

High-fat-diet-induced obesity and heart dysfunction are regulated by the TOR pathway in Drosophila.

Drosophila as a model to study cardiac aging.

Phospholipid homeostasis regulates lipid metabolism and cardiac function through SREBP signaling in Drosophila.

Phospholipid homeostasis and lipotoxic cardiomyopathy: a matter of balance.

A mighty small heart: the cardiac proteome of adult Drosophila melanogaster.

Tinman/Nkx2-5 acts via miR-1 and upstream of Cdc42 to regulate heart function across species.

ATP-sensitive potassium channel (K(ATP))-dependent regulation of cardiotropic viral infections.

The UNC-45 chaperone is critical for establishing myosin-based myofibrillar organization and cardiac contractility in the Drosophila heart model.

Lipotoxicity and cardiac dysfunction in mammals and Drosophila.

Over-expression of DSCAM and COL6A2 cooperatively generates congenital heart defects.

Measuring passive myocardial stiffness in Drosophila melanogaster to investigate diastolic dysfunction.

Probing the polygenic basis of cardiomyopathies in Drosophila.

Drosophila as a Model to Study the Genetic Mechanisms of Obesity-Associated Heart Dysfunction.

Regulation of parkin and PINK1 by neddylation.

Statin treatment increases lifespan and improves cardiac health in Drosophila by decreasing specific protein prenylation.

APJ acts as a dual receptor in cardiac hypertrophy.

A Drosophila model of high sugar diet-induced cardiomyopathy.

Declining signal-dependence of Nrf2-MafS regulated gene expressioncorrelates with aging phenotypes.

Complex genetic architecture of cardiac disease in a wild type inbred strain of Drosophila melanogaster.

Whole-Genome rVISTA: a tool to determine enrichment of transcription factor binding sites in gene promoters from transcriptomic data.

Survival response to increased ceramide involves metabolic adaptation through novel regulators of glycolysis and lipolysis.

Multiplexin promotes heart but not aorta morphogenesis by polarized enhancement of slit/robo activity at the heart lumen.

Pygopus maintains heart function in aging Drosophila independently of canonical Wnt signaling.

Mechanical and non-mechanical functions of Dystrophin can prevent cardiac abnormalities in Drosophila.

The role of pygopus in the differentiation of intracardiac valves in Drosophila.

Integrin-linked kinase modulates longevity and thermotolerance in C. elegans through neuronal control of HSF-1.

Huntington's disease induced cardiac amyloidosis is reversed by modulating protein folding and oxidative stress pathways in the Drosophila heart.

A dual role for integrin-linked kinase and β1-integrin in modulating cardiac aging.

Metabolic and transcriptional response to a high-fat diet in Drosophila melanogaster.

ROS regulate cardiac function via a distinct paracrine mechanism.

Systems genomics of metabolic phenotypes in wild-type Drosophila melanogaster.

Methods to assess Drosophila heart development, function and aging.

Cdc42 and formin activity control non-muscle myosin dynamics during Drosophila heart morphogenesis.

Notch Activation of Ca(2+) Signaling in the Development of Hypoxic Pulmonary Vasoconstriction and Pulmonary Hypertension.

PGC-1/Spargel Counteracts High-Fat-Diet-Induced Obesity and Cardiac Lipotoxicity Downstream of TOR and Brummer ATGL Lipase.

Cardiac deficiency of single cytochrome oxidase assembly factor scox induces p53-dependent apoptosis in a Drosophila cardiomyopathy model.

Clueless, a protein required for mitochondrial function, interacts with the PINK1-Parkin complex in Drosophila.

Genetic manipulation of cardiac ageing.

Vinculin network-mediated cytoskeletal remodeling regulates contractile function in the aging heart.

Obesity-associated cardiac dysfunction in starvation-selected Drosophila melanogaster.

Cellular Mechanisms of Drosophila Heart Morphogenesis.

Klf15 Is Critical for the Development and Differentiation of Drosophila Nephrocytes.

Cardiac responses to hypoxia and reoxygenation in Drosophila.

Gaining Insights into Diabetic Cardiomyopathy from Drosophila.

SPARC-Dependent Cardiomyopathy in Drosophila.

Drosophila as a potential model to ameliorate mutant Huntington-mediated cardiac amyloidosis.

High throughput physiological screening of iPSC-derived cardiomyocytes for drug development.

The canonical Wingless signaling pathway is required but not sufficient for inflow tract formation in the Drosophila melanogaster heart.

A Restrictive Cardiomyopathy Mutation in an Invariant Proline at the Myosin Head/Rod Junction Enhances Head Flexibility and Function, Yielding Muscle Defects in Drosophila.

52 Genetic Loci Influencing Myocardial Mass.

Extracellular matrix downregulation in the Drosophila heart preserves contractile function and improves lifespan.

Expression patterns of cardiac aging in Drosophila.

Modest overexpression of FOXO maintains cardiac proteostasis and ameliorates age-associated functional decline.

Experimental Evolution and Heart Function in Drosophila.

Morphological differentiation of the embryonic peripheral neurons in Drosophila.

A late role for a subset of neurogenic genes to limit sensory precursor recruitments in Drosophila embryos.

SLP-2 interacts with Parkin in mitochondria and prevents mitochondrial dysfunction in Parkin-deficient human iPSC-derived neurons and Drosophila.

Transcriptomic analysis identifies a role of PI3K-Akt signalling in the responses of skeletal muscle to acute hypoxia in vivo.