Department of Pharmacological Sciences
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Partial rescue of neural apoptosis in the Lurcher mutant mouse through elimination of tissue plasminogen activator.
Development (Cambridge, England) Apr, 2002 | Pubmed ID: 11934869
Tissue plasminogen activator mediates microglial activation via its finger domain through annexin II.
The Journal of neuroscience : the official journal of the Society for Neuroscience May, 2002 | Pubmed ID: 11978811
Extracellular proteases and neuronal cell death.
Cellular and molecular biology (Noisy-le-Grand, France) Mar, 2002 | Pubmed ID: 11990450
Tissue plasminogen activator as a modulator of neuronal survival and function.
Biochemical Society transactions Apr, 2002 | Pubmed ID: 12023855
Microglial activation and recruitment, but not proliferation, suffice to mediate neurodegeneration.
Cell death and differentiation Aug, 2002 | Pubmed ID: 12107823
Involvement of tissue plasminogen activator in onset and effector phases of experimental allergic encephalomyelitis.
The Journal of neuroscience : the official journal of the Society for Neuroscience Dec, 2002 | Pubmed ID: 12486171
Cell type-specific roles for tissue plasminogen activator released by neurons or microglia after excitotoxic injury.
The Journal of neuroscience : the official journal of the Society for Neuroscience Apr, 2003 | Pubmed ID: 12716930
Protective role of tuftsin fragment 1-3 in an animal model of intracerebral hemorrhage.
Annals of neurology Nov, 2003 | Pubmed ID: 14595655
Modulation of zinc toxicity by tissue plasminogen activator.
Molecular and cellular neurosciences Jan, 2004 | Pubmed ID: 14962749
Increased expression of two phospholipase D isoforms during experimentally induced hippocampal mossy fiber outgrowth.
Glia Apr, 2004 | Pubmed ID: 14999815
Tissue plasminogen activator and glial function.
Glia Jan, 2005 | Pubmed ID: 15494978
Tuftsin fragment 1-3 is beneficial when delivered after the induction of intracerebral hemorrhage.
Stroke; a journal of cerebral circulation Mar, 2005 | Pubmed ID: 15692122
Phospholipase D1-promoted release of tissue plasminogen activator facilitates neurite outgrowth.
The Journal of neuroscience : the official journal of the Society for Neuroscience Feb, 2005 | Pubmed ID: 15716416
Neuroprotection by inhibition of matrix metalloproteinases in a mouse model of intracerebral haemorrhage.
Brain : a journal of neurology Jul, 2005 | Pubmed ID: 15800021
Fibrin-modifying serine proteases thrombin, tPA, and plasmin in ischemic stroke: a review.
Glia Jun, 2005 | Pubmed ID: 15846799
Contribution of extracellular proteolysis and microglia to intracerebral hemorrhage.
Neurocritical care , 2005 | Pubmed ID: 16159103
PET imaging of glucose metabolism in a mouse model of temporal lobe epilepsy.
Synapse (New York, N.Y.) Feb, 2006 | Pubmed ID: 16320304
Nitric oxide mediates neurodegeneration and breakdown of the blood-brain barrier in tPA-dependent excitotoxic injury in mice.
Journal of cell science Jan, 2006 | Pubmed ID: 16410551
Proteolytic activation of monocyte chemoattractant protein-1 by plasmin underlies excitotoxic neurodegeneration in mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience Feb, 2007 | Pubmed ID: 17301181
Nitric oxide synthase isoforms undertake unique roles during excitotoxicity.
Stroke; a journal of cerebral circulation Jun, 2007 | Pubmed ID: 17446423
Brain edema after intracerebral hemorrhage: mechanisms, treatment options, management strategies, and operative indications.
Neurosurgical focus , 2007 | Pubmed ID: 17613237
Modulation of microglial/macrophage activation by macrophage inhibitory factor (TKP) or tuftsin (TKPR) attenuates the disease course of experimental autoimmune encephalomyelitis.
BMC immunology , 2007 | Pubmed ID: 17634104
A novel approach for imaging brain-behavior relationships in mice reveals unexpected metabolic patterns during seizures in the absence of tissue plasminogen activator.
NeuroImage Oct, 2007 | Pubmed ID: 17707126
tPA-mediated generation of plasmin is catalyzed by the proteoglycan NG2.
Glia Jan, 2008 | Pubmed ID: 18000864
Tissue-type plasminogen activator as a therapeutic target in stroke.
Expert opinion on therapeutic targets Feb, 2008 | Pubmed ID: 18208365
Endothelial NOS-deficient mice reveal dual roles for nitric oxide during experimental autoimmune encephalomyelitis.
Glia Aug, 2009 | Pubmed ID: 19170181
Decreased serotonin levels associated with behavioral disinhibition in tissue plasminogen activator deficient (tPA-/-) mice.
Brain research Apr, 2010 | Pubmed ID: 20156421
Microglial ablation and lipopolysaccharide preconditioning affects pilocarpine-induced seizures in mice.
Neurobiology of disease Jul, 2010 | Pubmed ID: 20382223
Tissue plasminogen activator alters intracellular sequestration of zinc through interaction with the transporter ZIP4.
The Journal of neuroscience : the official journal of the Society for Neuroscience May, 2010 | Pubmed ID: 20463217
The C terminus of mouse monocyte chemoattractant protein 1 (MCP1) mediates MCP1 dimerization while blocking its chemotactic potency.
The Journal of biological chemistry Oct, 2010 | Pubmed ID: 20682771
Microglia shape adult hippocampal neurogenesis through apoptosis-coupled phagocytosis.
Cell stem cell Oct, 2010 | Pubmed ID: 20887954
Microglia/macrophages promote glioma progression.
Glia Mar, 2011 | Pubmed ID: 21264953
Truncation of monocyte chemoattractant protein 1 by plasmin promotes blood-brain barrier disruption.
Journal of cell science May, 2011 | Pubmed ID: 21486949
Mouse MCP1 C-terminus inhibits human MCP1-induced chemotaxis and BBB compromise.
Journal of neurochemistry Jul, 2011 | Pubmed ID: 21615737
Annexin A2 promotes glioma cell invasion and tumor progression.
The Journal of neuroscience : the official journal of the Society for Neuroscience Oct, 2011 | Pubmed ID: 21976520
Axonal regrowth after spinal cord injury via chondroitinase and the tissue plasminogen activator (tPA)/plasmin system.
The Journal of neuroscience : the official journal of the Society for Neuroscience Oct, 2011 | Pubmed ID: 22016526
Animal Models of MS Reveal Multiple Roles of Microglia in Disease Pathogenesis.
Neurology research international , 2011 | Pubmed ID: 22203900
The CCL2-CCR2 system affects the progression and clearance of intracerebral hemorrhage.
Glia May, 2012 | Pubmed ID: 22419223
Quantification of particle-induced inflammatory stress response: a novel approach for toxicity testing of earth materials.
Geochemical transactions , 2012 | Pubmed ID: 22513118
Tuftsin promotes an anti-inflammatory switch and attenuates symptoms in experimental autoimmune encephalomyelitis.
PloS one , 2012 | Pubmed ID: 22529957
Microglial inhibitory factor (MIF/TKP) mitigates secondary damage following spinal cord injury.
Neurobiology of disease Sep, 2012 | Pubmed ID: 22613732
p53 opens the mitochondrial permeability transition pore to trigger necrosis.
Cell Jun, 2012 | Pubmed ID: 22726440
Inflammation modulates expression of laminin in the central nervous system following ischemic injury.
Journal of neuroinflammation , 2012 | Pubmed ID: 22759265
Neuroimaging in Animal Seizure Models with (18)FDG-PET.
Epilepsy research and treatment , 2011 | Pubmed ID: 22937232
The annexin A2/S100A10 system in health and disease: emerging paradigms.
Journal of biomedicine & biotechnology , 2012 | Pubmed ID: 23193360
Microglia actively regulate the number of functional synapses.
PloS one , 2013 | Pubmed ID: 23393609
Members of the high mobility group B protein family are dynamically expressed in embryonic neural stem cells.
Proteome science , 2013 | Pubmed ID: 23621913
Inflammatory stress response in A549 cells as a result of exposure to coal: Evidence for the role of pyrite in coal workers' pneumoconiosis pathogenesis.
Chemosphere Jul, 2013 | Pubmed ID: 23895739
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