Elizabethtown College
2 ARTICLES PUBLISHED IN JoVE
Behavior
Examination of Rapid Dopamine Dynamics with Fast Scan Cyclic Voltammetry During Intra-oral Tastant Administration in Awake Rats
Robert J. Wickham 1, Jinwoo Park 2, Eric J. Nunes 3, Nii A. Addy 1,3,4
1Interdepartmental Neuroscience Program, Yale University, 2Department of Biotechnical and Clinical Laboratory Sciences, School of Medicine and Biomedical Sciences, University at Buffalo, 3Department of Psychiatry, Yale School of Medicine, 4Department of Cellular and Molecular Physiology, Yale School of Medicine
Rapid fluctuations in extracellular dopamine (DA) mediate both reward processing and motivated behavior in mammals. This manuscript describes the combined use of fast scan cyclic voltammetry (FSCV) and intra-oral tastant administration to determine how tastants alter rapid dopamine release in awake, freely moving rats.
Neuroscience
Combined Infusion and Stimulation with Fast-Scan Cyclic Voltammetry (CIS-FSCV) to Assess Ventral Tegmental Area Receptor Regulation of Phasic Dopamine
Robert J. Wickham 1, Makenzie Lehr *1, Lauryn Mitchell *1, Nii A. Addy 2,3
1Department of Psychology, Elizabethtown College, 2Department of Psychiatry, Yale University, 3Department of Cellular and Molecular Physiology, Yale University
The goal of this protocol is to directly manipulate ventral tegmental area receptors to study their contribution to subsecond dopamine release.
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