A Human Bone Marrow 3D Model to Investigate the Dynamics and Interactions Between Resident Cells in Physiological or Tumoral ContextsKawtar Arizkane 1,2,3, Kevin Geistlich 1,2,3,4, Laurine Moindrot 1,2,3, Emma Risson 1,2,3, Sandrine Jeanpierre 1,2,3,4, Léa Barral 1,2,3, Anaëlle Bobard 1,2,3, Giulio Menegazzi 5, Thibault Voeltzel 1,2,3, Véronique Maguer-Satta 1,2,3, Sylvain Lefort 1,2,3
1Centre de Recherche en Cancérologie de Lyon, 2Centre de Recherche en Cancérologie de Lyon, 3Université de Lyon, 4Centre Léon Bérard, 5Department of Experimental and Clinical Biomedical Sciences Mario Serio, Università degli Studi di Firenze
Here, we describe an easy-to-implement, standardized, microphysiological system that reflects the complexity of the human bone marrow's in vivo structure, providing a pertinent model to finely study a broad range of normal and pathological events.
