Università degli Studi di Firenze

1 ARTICLES PUBLISHED IN JoVE

Biology

A Human Bone Marrow 3D Model to Investigate the Dynamics and Interactions Between Resident Cells in Physiological or Tumoral Contexts

Kawtar Arizkane^1,2,3, Kevin Geistlich^1,2,3,4, Laurine Moindrot^1,2,3, Emma Risson^1,2,3, Sandrine Jeanpierre^1,2,3,4, Léa Barral^1,2,3, Anaëlle Bobard^1,2,3, Giulio Menegazzi⁵, Thibault Voeltzel^1,2,3, Véronique Maguer-Satta^1,2,3, Sylvain Lefort^1,2,3

¹Centre de Recherche en Cancérologie de Lyon, ²Centre de Recherche en Cancérologie de Lyon, ³Université de Lyon, ⁴Centre Léon Bérard, ⁵Department of Experimental and Clinical Biomedical Sciences Mario Serio, Università degli Studi di Firenze

Here, we describe an easy-to-implement, standardized, microphysiological system that reflects the complexity of the human bone marrow's in vivo structure, providing a pertinent model to finely study a broad range of normal and pathological events.