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university of south wales

2 ARTICLES PUBLISHED IN JoVE

Medicine

Doppler Ultrasound-Based Leg Blood Flow Assessment During Single-Leg Knee-Extensor Exercise in an Uncontrolled Setting

Jacob Peter Hartmann^1,2,3, Rikke Krabek¹, Stine B. Nymand^1,3, Helene Hartmeyer¹, Lasse Gliemann⁴, Ronan M. G. Berg^1,2,3,5, Ulrik Winning Iepsen^1,6

¹Centre for Physical Activity Research, Copenhagen University Hospital, ²Department of Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital, ³Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, ⁴Department of Nutrition, Exercise and Sports, Integrated Physiology Group, ⁵Neurovascular Research Laboratory, Faculty of Life Sciences and Education, University of South Wales, ⁶Department of Anaesthesiology and Intensive Care, Copenhagen University Hospital, Hvidovre Hospital

This test-retest study evaluated leg blood flow measured by the Doppler ultrasound technique during single-leg knee-extensor exercise. The within-day, between-day, and inter-rater reliability of the method was investigated. The approach demonstrated high within-day and acceptable between-day reliability. However, the inter-rater reliability was unacceptably low during rest and at low workloads.

Medicine

Dual Test Gas Pulmonary Diffusing Capacity Measurement During Exercise in Humans Using the Single-Breath Method

Stine B. Nymand¹, Jacob Peter Hartmann^1,2,3, Helene Louise Hartmeyer¹, Iben E. Rasmussen¹, Amalie Bach Andersen¹, Milan Mohammad¹, Susan Al-Atabi³, Birgitte Hanel³, Ulrik Winning Iepsen^1,4, Jann Mortensen^3,5, Ronan M. G. Berg^1,2,3,6

¹Centre for Physical Activity Research, Copenhagen University Hospital - Rigshospitalet, ²Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, ³Department of Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital - Rigshospitalet, ⁴Department of Anesthesiology and Intensive Care, Hvidovre Hospital, ⁵Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, ⁶Neurovascular Research Laboratory, Faculty of Life Sciences and Education, University of South Wales

This protocol presents a method to assess pulmonary alveolar-capillary reserve measured by combined single-breath measurement of the diffusing capacity to carbon monoxide (D_L,CO) and nitric oxide (D_L,NO) during exercise. Assumptions and recommendations for using the technique during exercise form the foundation of this article.