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Harvard Medical School - BIDMC

1 ARTICLES PUBLISHED IN JoVE

Immunology and Infection

An Endothelial Planar Cell Model for Imaging Immunological Synapse Dynamics

Roberta Martinelli¹, Christopher V. Carman¹

¹Department of Medicine, Harvard Medical School - BIDMC

Adaptive immunity is controlled by dynamic 'immunological synapses' formed between T cells and antigen presenting cells. This protocol describes methods for investigating endothelial cells both as understudied physiologic APCs and as a novel type of 'planar cellular APC model'.