Chapter 11
Control of Gene Expression
Expresión génica específica de la célula
Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same ...
La regulación de la expresión se produce en varios pasos
Gene expression can be regulated at almost every step from gene to protein. Transcription is the step that is most commonly regulated. This involves the ...
Secuencias cis-reguladoras
Cis-regulatory sequences are short fragments of non-coding DNA that are present on the same chromosomes as the genes that they regulate. These fragments ...
Unión cooperativa de reguladores de transcripción
Transcriptional regulators bind to specific cis-regulatory sequences in the DNA to regulate gene transcription. These cis-regulatory sequences are ...
Activadores y represores transcripcionales procariotas
The organization of prokaryotic genes in their genome is notably different from that of eukaryotes. Prokaryotic genes are organized, such that the genes ...
La región promotora eucariota
The eukaryotic promoter region is a segment of DNA located upstream of a gene. It contains an RNA polymerase binding site, a transcription start site, and ...
Co-activadores y co-represores
Gene transcription is regulated by the synergistic action of several proteins that form a complex at a gene regulatory site. This is observed in ...
Reguladores de transcripción maestros
Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these ...
Transporte regulado de ARNm
In eukaryotes, transcription and translation are compartmentalized; an mRNA is first synthesized in the nucleus and then selectively transported to the ...
Estabilidad del ARNm y expresión génica
The structure and stability of mRNA molecules regulates gene expression, as mRNAs are a key step in the pathway from gene to protein. In eukaryotes, the ...
MicroARN
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between ...
ARN interferente pequeño (ARNsi)
Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional ...
lncRNA - ARN largo no codificante
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding ...
Regulación epigenética
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. ...
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