Name: functional mapping with simultaneous meg and eeg
Uploaded: 2010-06-14T19:00:00
Description: Watch this Scientific Journal Video about Functional Mapping with Simultaneous MEG and EEG at JoVE.com

1. Check system tuning and data quality
<ol>
<li>Check the tuning of the MEG system. Use the tuning and noise measurement software provided with the MEG system to check that all channels are properly tuned and that the average noise level is below 3 fT/cm or 3 fT on planar gradiometer and magnetometer MEG channels, respectively.</li>
<li>Collect a segment of empty room data. Acquire data with the shielded room void of subject for 5 minutes for quality assurance and noise estimation.</li>
</ol>
<p class="jove_title...

<ol>
	<li>H&#228;m&#228;l&#228;inen, M., Hari, R., Ilmoniemi, R., Knuutila, J., Lounasmaa, O. V. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Magnetoencephalography+-+theory,+instrumentation,+and+applications+to+noninvasive+studies+of+the+working+human+brain.">Magnetoencephalography - theory, instrumentation, and applications to noninvasive studies of the working human brain.</a> Reviews of Modern Physics. 65, 413-497 (1993).</li><li>H&#228;m&#228;l&#228;inen, M., Hari, R., Toga, A. W., Mazziotta, J. C. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=.">.</a> Brain Mapping, The Methods. , 227-253 (2002).</li><li>Sharon, D., H&#228;m&#228;l&#228;inen, M., Tootell, R. B., Halgren, E., Belliveau, J. W. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=The+advantage+of+combining+MEG+and+EEG:+Comparison+to+fMRI+in+focally+stimulated+visual+cortex.">The advantage of combining MEG and EEG: Comparison to fMRI in focally stimulated visual cortex.</a> Neuroimage. 36, 1225-1235 (2007).</li><li>M&#228;kel&#228;, J. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Three-dimensional+integration+of+brain+anatomy+and+function+to+facilitate+intraoperative+navigation+around+the+sensorimotor+strip.">Three-dimensional integration of brain anatomy and function to facilitate intraoperative navigation around the sensorimotor strip.</a> Human Brain Mapping. 12, 180-192 (2001).</li></ol>

Magnetoencephalography (MEG) and electroencephalography (EEG) are the only non-invasive methods to record brain activity with a fine temporal resolution. MEG is especially well suited for studying cortical activity. This article demonstrates combined MEG/EEG data acquisition and analysis to determined brain activity associated with the processing of simple sensory stimuli. These type of experiments are used both in basic neuroscience and clinical studies. If the brain activation is focal, the current dipole model applies...

functional mapping with simultaneous meg and eeg

We use magnetoencephalography (MEG) and electroencephalography (EEG) to locate and determine the temporal evolution in brain areas involved in the processing of simple sensory stimuli. We will use somatosensory stimuli to locate the hand somatosensory areas, auditory stimuli to locate the auditory cortices, visual stimuli in four quadrants of the visual field to locate the early visual areas. These type of experiments are used for functional mapping in epileptic and brain tumor patients to locate eloquent cortices. In basic neuroscience similar experimental protocols are used to study the orchestration of cortical activity. The acquisition protocol includes quality assurance procedures, subject preparation for the combined MEG/EEG study, and acquisition of evoked-response data with somatosensory, auditory, and visual stimuli. We also demonstrate analysis of the data using the equivalent current dipole model and cortically-constrained minimum-norm estimates. Anatomical MRI data are employed in the analysis for visualization and for deriving boundaries of tissue boundaries for forward modeling and cortical location and orientation constraints for the minimum-norm estimates.

Watch this Scientific Journal Video about Functional Mapping with Simultaneous MEG and EEG at JoVE.com

Functional Mapping with Simultaneous MEG and EEG

We use magnetoencephalography (MEG) and electroencephalography (EEG) to map brain areas involved in the processing of simple sensory stimuli.

We use magnetoencephalography (MEG) and electroencephalography (EEG) to locate and determine the temporal evolution in brain areas involved in the ...

Research

JoVE Journal

Neuroscience

Combining Computer Game-Based Behavioural Experiments With High-Density EEG and Infrared Gaze Tracking

Experimental paradigms are valuable insofar as the timing and other parameters of their stimuli are well specified and controlled, and insofar as they ...

Single Cell Measurement of Dopamine Release with Simultaneous Voltage-clamp and Amperometry

After its release into the synaptic cleft, dopamine exerts its biological properties via its pre- and post-synaptic targets1. The dopamine signal is ...

Recording Human Electrocorticographic (ECoG) Signals for Neuroscientific Research and Real-time Functional Cortical Mapping

Recording Human Electrocorticographic ECoG Signals for Neuroscientific Research and Real-time Functional Cortical Mapping

Neuroimaging studies of human cognitive, sensory, and motor processes are usually based on noninvasive techniques such as electroencephalography (EEG), ...

Mapping Cortical Dynamics Using Simultaneous MEG/EEG and Anatomically-constrained Minimum-norm Estimates: an Auditory Attention Example

Magneto- and electroencephalography (MEG/EEG) are neuroimaging techniques that provide a high temporal resolution particularly suitable to investigate the ...

Functional Interrogation of Adult Hypothalamic Neurogenesis with Focal Radiological Inhibition

The functional characterization of adult-born neurons remains a significant challenge. Approaches to inhibit adult neurogenesis via invasive viral ...

Functional Imaging of Auditory Cortex in Adult Cats using High-field fMRI

Current knowledge of sensory processing in the mammalian auditory system is mainly derived from electrophysiological studies in a variety of animal ...

Deep Brain Stimulation with Simultaneous fMRI in Rodents

In order to visualize the global and downstream neuronal responses to deep brain stimulation (DBS) at various targets, we have developed a protocol for ...

Simultaneous ex vivo Functional Testing of Two Retinas by in vivo Electroretinogram System

Simultaneous ex vivo Functional Testing of Two Retinas by in vivo Electroretinogram System

An In vivo electroretinogram (ERG) signal is composed of several overlapping components originating from different retinal cell types, as well as noise ...

Non-restraining EEG Radiotelemetry: Epidural and Deep Intracerebral Stereotaxic EEG Electrode Placement

Implantable EEG radiotelemetry is of central relevance in the neurological characterization of transgenic mouse models of neuropsychiatric and ...

Analyzing Neural Activity and Connectivity Using Intracranial EEG Data with SPM Software

Measuring neural activity and connectivity associated with cognitive functions at high spatial and temporal resolutions is an important goal in cognitive ...