Crosslinking the Microgels and Triggering Drug Release
5:39
Measuring Drug Release from the Microgels
6:39
Results: TR-BSA Release from Microgels Incorporating p(NIPAM-co-AAm) Chains and Superparamagnetic Nanoparticles
8:23
Conclusion
Transcribir
This overall goal of this protocol is to present a facile method for fabrication of magnetothermally responsive nanoparticle microgel hybrids, and to demonstrate a proof of concept on the use of the microgel hybrids for controllable drug release.
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We present a facile method to fabricate a biodegradable gelatin-based drug release platform that is magneto-thermally responsive. This was achieved by incorporating superparamagnetic iron oxide nanoparticles and poly(N-isopropylacrylamide-co-acrylamide) within a spherical gelatin micro-network crosslinked by genipin, in conjunction with an alternating magnetic field application system.