The overall goal of this procedure is to break down all glycans in a biological sample while conserving monosaccharide composition and linkage information. Facilitating distillation of interesting glycan features such as sick cyalalation and bisec
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This article presents an enhanced form of a novel bottom-up glycomics technique designed to analyze the pooled compositional profile of glycans in unfractionated biofluids through the chemical breakdown of glycans into their constituent linkage-specific monosaccharides for detection by GC-MS. Potential applications include early detection of cancer and other glycan-affective disorders.