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Glycan Node Analysis: A Bottom-up Approach to Glycomics

DOI :

10.3791/53961-v

May 22nd, 2016

May 22nd, 2016

10,036 Views

1Department of Chemistry & Biochemistry, The Biodesign Institute – Center for Personalized Diagnostics, Arizona State University

This article presents an enhanced form of a novel bottom-up glycomics technique designed to analyze the pooled compositional profile of glycans in unfractionated biofluids through the chemical breakdown of glycans into their constituent linkage-specific monosaccharides for detection by GC-MS. Potential applications include early detection of cancer and other glycan-affective disorders.

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