Results: JAM-A Regulates Intestinal Permeability in vivo and Promotes LTB4-dependent Recruitment of PMN into the Lumen of the pcLoop
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Conclusion
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The intestinal model is a widely adaptable and physiologic way to measure how leaky the gut is and how leukocytes migrate in the intestine in mice, in vivo. This method helps to better understand mechanisms underlying increased intestinal permeabi
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Dysregulated intestinal epithelial barrier function and immune responses are hallmarks of inflammatory bowel disease that remain poorly investigated due to a lack of physiological models. Here, we describe a mouse intestinal loop model that employs a well-vascularized and exteriorized bowel segment to study mucosal permeability and leukocyte recruitment in vivo.