Inti Zlobec

A predictive model of rectal tumor response to preoperative radiotherapy using classification and regression tree methods.

VEGF as a predictive marker of rectal tumor response to preoperative radiotherapy.

The predictive value of apoptosis protease-activating factor 1 in rectal tumors treated with preoperative, high-dose-rate brachytherapy.

Scoring of p53, VEGF, Bcl-2 and APAF-1 immunohistochemistry and interobserver reliability in colorectal cancer.

Overexpression of the receptor for hyaluronic acid mediated motility is an independent adverse prognostic factor in colorectal cancer.

Role of the mitogen-activated protein kinase and phosphoinositide 3-kinase/AKT pathways downstream molecules, phosphorylated extracellular signal-regulated kinase, and phosphorylated AKT in colorectal cancer-a tissue microarray-based approach.

Prognostic value of cell cycle and apoptosis regulatory proteins in mismatch repair-proficient colorectal cancer: a tissue microarray-based approach.

Selecting immunohistochemical cut-off scores for novel biomarkers of progression and survival in colorectal cancer.

Intratumoral budding as a potential parameter of tumor progression in mismatch repair-proficient and mismatch repair-deficient colorectal cancer patients.

Napoleon Bonaparte's gastric cancer: a clinicopathologic approach to staging, pathogenesis, and etiology.

Differential significance of tumour infiltrating lymphocytes in sporadic mismatch repair deficient versus proficient colorectal cancers: a potential role for dysregulation of the transforming growth factor-beta pathway.

Prognostic significance of mammalian sterile20-like kinase 1 in colorectal cancer.

Loss of APAF-1 expression is associated with tumour progression and adverse prognosis in colorectal cancer.

Loss of raf-1 kinase inhibitor protein expression is associated with tumor progression and metastasis in colorectal cancer.

HER2 gene status in primary breast cancers and matched distant metastases.

Value of staining intensity in the interpretation of immunohistochemistry for tumor markers in colorectal cancer.

Multimarker phenotype predicts adverse survival in patients with lymph node-negative colorectal cancer.

Node-negative colorectal cancer at high risk of distant metastasis identified by combined analysis of lymph node status, vascular invasion, and Raf-1 kinase inhibitor protein expression.

KIT, PDGFRalpha and EGFR analysis in nephroblastoma.

Local recurrence in mismatch repair-proficient colon cancer predicted by an infiltrative tumor border and lack of CD8+ tumor-infiltrating lymphocytes.

RHAMM, p21 combined phenotype identifies microsatellite instability-high colorectal cancers with a highly adverse prognosis.

Differential diagnostic and functional role of the multi-marker phenotype CDX2/CK20/CK7 in colorectal cancer stratified by mismatch repair status.

Is immunohistochemical epidermal growth factor receptor expression overestimated as a prognostic factor in head-neck squamous cell carcinoma? A retrospective analysis based on a tissue microarray of 365 carcinomas.

Clinical significance of cell cycle- and apoptosis-related markers in biliary tract cancer: a tissue microarray-based approach revealing a distinctive immunophenotype for intrahepatic and extrahepatic cholangiocarcinomas.

Immunophenotyping and oncogene amplifications in tumors of the papilla of Vater.

Expression of CD24, P-cadherin and S100A4 in tumors of the ampulla of Vater.

Tumour growth fraction measured by immunohistochemical staining of Ki67 is an independent prognostic factor in preoperative prostate biopsies with small-volume or low-grade prostate cancer.

The prognostic value of cytology and fluorescence in situ hybridization in the follow-up of nonmuscle-invasive bladder cancer after intravesical Bacillus Calmette-Guérin therapy.

HOX D13 expression across 79 tumor tissue types.

Tumor border configuration added to TNM staging better stratifies stage II colorectal cancer patients into prognostic subgroups.

Combined histomorphologic and immunohistochemical phenotype to predict the presence of vascular invasion in colon cancer.

Assessment of mean EGFR gene copy number is a highly reproducible method for evaluating FISH in histological and cytological cancer specimens.

Is the improved prognosis of p16 positive oropharyngeal squamous cell carcinoma dependent of the treatment modality?

Urokinase-type plasminogen activator is a marker of aggressive phenotype and an independent prognostic factor in mismatch repair-proficient colorectal cancer.

High frequency of tumor-infiltrating FOXP3(+) regulatory T cells predicts improved survival in mismatch repair-proficient colorectal cancer patients.

Clinicopathological and protein characterization of BRAF- and K-RAS-mutated colorectal cancer and implications for prognosis.

Systematic assessment of the prognostic impact of membranous CD44v6 protein expression in colorectal cancer.

Prognostic immunophenotypic biomarker studies in diffuse large B cell lymphoma with special emphasis on rational determination of cut-off scores.

Invasive front of colorectal cancer: dynamic interface of pro-/anti-tumor factors.

BOB.1, CD79a and cyclin E are the most appropriate markers to discriminate classical Hodgkin's lymphoma from primary mediastinal large B-cell lymphoma.

ABCG5-positivity in tumor buds is an indicator of poor prognosis in node-negative colorectal cancer patients.

Fluorescence in situ hybridization in the definitive diagnosis of malignant mesothelioma in effusion cytology.

Combined analysis of specific KRAS mutation, BRAF and microsatellite instability identifies prognostic subgroups of sporadic and hereditary colorectal cancer.

Loss of the CBX7 protein expression correlates with a more aggressive phenotype in pancreatic cancer.

Role of the VEGF ligand to receptor ratio in the progression of mismatch repair-proficient colorectal cancer.

Differential cell cycle and proliferation marker expression in ductal pancreatic adenocarcinoma and pancreatic intraepithelial neoplasia (PanIN).

The loss of the CBX7 gene expression represents an adverse prognostic marker for survival of colon carcinoma patients.

Role of tumor size in the pre-operative management of rectal cancer patients.

Expression of p16 in lymph node metastases of adjuvantly treated stage III colorectal cancer patients identifies poor prognostic subgroups: a retrospective analysis of biomarkers in matched primary tumor and lymph node metastases.

Tumor infiltration by FcγRIII (CD16)+ myeloid cells is associated with improved survival in patients with colorectal carcinoma.

Systematic assessment of protein phenotypes characterizing high-grade tumour budding in mismatch repair-proficient colorectal cancer.

Co-overexpression of p21 and Ki-67 in head and neck squamous cell carcinoma relative to a significantly poor prognosis.

Tumor budding predicts response to anti-EGFR therapies in metastatic colorectal cancer patients.

TIA-1 cytotoxic granule-associated RNA binding protein improves the prognostic performance of CD8 in mismatch repair-proficient colorectal cancer.

Can molecular markers stratify the diagnostic value of high-grade prostatic intraepithelial neoplasia?

Deletion of the inhibitor of growth 4 (ING4) tumor suppressor gene is prevalent in human epidermal growth factor 2 (HER2)-positive breast cancer.

Epithelial mesenchymal transition and tumor budding in aggressive colorectal cancer: tumor budding as oncotarget.

High-level cytoplasmic cyclin D1 expression in lymph node metastases from prostate cancer independently predicts early biochemical failure and death in surgically treated patients.

Assessing downgrading of locally advanced rectal cancer after chemo-radiotherapy.

High CD10 expression in lymph node metastases from surgically treated prostate cancer independently predicts early death.

Comprehensive analysis of CpG island methylator phenotype (CIMP)-high, -low, and -negative colorectal cancers based on protein marker expression and molecular features.

Systematic analysis of proteins from different signaling pathways in the tumor center and the invasive front of colorectal cancer.

Prognostic significance of CD8+ T lymphocytes in breast cancer depends upon both oestrogen receptor status and histological grade.

VEGFA gene locus (6p12) amplification identifies a small but highly aggressive subgroup of colorectal cancer [corrected] patients.

Immunophenotyping analysis in invasive micropapillary carcinoma of the breast: role of CD24 and CD44 isoforms expression.

Characterization of the immunological microenvironment of tumour buds and its impact on prognosis in mismatch repair-proficient and -deficient colorectal cancers.

Effect of EpCAM, CD44, CD133 and CD166 expression on patient survival in tumours of the ampulla of Vater.

Standardization of whole slide image morphologic assessment with definition of a new application: Digital slide dynamic morphometry.

HMGA1 and HMGA2 protein expression correlates with advanced tumour grade and lymph node metastasis in pancreatic adenocarcinoma.

Differential pattern and prognostic significance of CD4+, FOXP3+ and IL-17+ tumor infiltrating lymphocytes in ductal and lobular breast cancers.

Intra-tumoral budding in preoperative biopsy specimens predicts lymph node and distant metastasis in patients with colorectal cancer.

The clinical impact of p16 status in fine-needle aspirates of cervical lymph node metastasis of head and neck squamous cell carcinomas.

Stratification and Prognostic Relevance of Jass's Molecular Classification of Colorectal Cancer.

Diagnostic reproducibility of tumour budding in colorectal cancer: a multicentre, multinational study using virtual microscopy.

The impact of CpG island methylator phenotype and microsatellite instability on tumour budding in colorectal cancer.

Prognostic impact of β-2-microglobulin expression in colorectal cancers stratified by mismatch repair status.

Role of KCNMA1 in Breast Cancer.

Role of intra- and peritumoral budding in the interdisciplinary management of rectal cancer patients.

Characterization of CDKN2A(p16) methylation and impact in colorectal cancer: systematic analysis using pyrosequencing.

Proposal for a 10-high-power-fields scoring method for the assessment of tumor budding in colorectal cancer.

Cancer classification using the Immunoscore: a worldwide task force.

Klf4 transcription factor is expressed in the cytoplasm of prostate cancer cells.

Tumor budding score based on 10 high-power fields is a promising basis for a standardized prognostic scoring system in stage II colorectal cancer.

Prediction of outcome in patients with low-grade squamous intraepithelial lesions by fluorescence in situ hybridization analysis of human papillomavirus, TERC, and MYC.

Clinical impact of programmed cell death ligand 1 expression in colorectal cancer.

Novel biomarkers for the prediction of metastasis in colorectal cancer.

Estrogen receptor β expression and androgen receptor phosphorylation correlate with a poor clinical outcome in hormone-naive prostate cancer and are elevated in castration-resistant disease.

Next-generation tissue microarray (ngTMA) increases the quality of biomarker studies: an example using CD3, CD8, and CD45RO in the tumor microenvironment of six different solid tumor types.

High myeloperoxidase positive cell infiltration in colorectal cancer is an independent favorable prognostic factor.

The growing galectin network in colon cancer and clinical relevance of cytoplasmic galectin-3 reactivity.

ATG5 is induced by DNA-damaging agents and promotes mitotic catastrophe independent of autophagy.

The apoptotic and proliferation rate of tumour budding cells in colorectal cancer outlines a heterogeneous population of cells with various impacts on clinical outcome.

Towards the introduction of the 'Immunoscore' in the classification of malignant tumours.

Loss of Cdx2 Expression in Primary Tumors and Lymph Node Metastases is Specific for Mismatch Repair-Deficiency in Colorectal Cancer.

Possible role of Cdx2 in the serrated pathway of colorectal cancer characterized by BRAF mutation, high-level CpG Island methylator phenotype and mismatch repair-deficiency.

A multifactorial histopathologic score for the prediction of prognosis of resected esophageal adenocarcinomas after neoadjuvant chemotherapy.

Neonatal Fc receptor expression in dendritic cells mediates protective immunity against colorectal cancer.

Loss of Raf-1 kinase inhibitor protein (RKIP) is strongly associated with high-grade tumor budding and correlates with an aggressive phenotype in pancreatic ductal adenocarcinoma (PDAC).

HLA class II antigen expression in colorectal carcinoma tumors as a favorable prognostic marker.

Proper paraffin slide storage is crucial for translational research projects involving immunohistochemistry stains.

CD8/CD45RO T-cell infiltration in endoscopic biopsies of colorectal cancer predicts nodal metastasis and survival.

Investigation of IL-23 (p19, p40) and IL-23R identifies nuclear expression of IL-23 p19 as a favorable prognostic factor in colorectal cancer: a retrospective multicenter study of 675 patients.

Assessment of Tumor Regression of Esophageal Adenocarcinomas After Neoadjuvant Chemotherapy: Comparison of 2 Commonly Used Scoring Approaches.

Tumor budding in upper gastrointestinal carcinomas.