S'identifier

Christopher D. Kane

Henry M. Jackson Foundation

BIOGRAPHY

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PUBLICATIONS

Proteomic analysis of calcium/calmodulin-dependent protein kinase I and IV in vitro substrates reveals distinct catalytic preferences.

The Journal of biological chemistry Mar, 2003 | Pubmed ID: 12538590

Differential regulation of the cynomolgus, human, and rat acyl-CoA oxidase promoters by PPARalpha.

Gene Oct, 2006 | Pubmed ID: 16828988

Effects of modifications of the linker in a series of phenylpropanoic acid derivatives: Synthesis, evaluation as PPARalpha/gamma dual agonists, and X-ray crystallographic studies.

Bioorganic & medicinal chemistry May, 2008 | Pubmed ID: 18394907

The hydrophobic tunnel present in LOX-1 is essential for oxidized LDL recognition and binding.

Journal of lipid research Mar, 2009 | Pubmed ID: 18845619

Molecular characterization of novel and selective peroxisome proliferator-activated receptor alpha agonists with robust hypolipidemic activity in vivo.

Molecular pharmacology Feb, 2009 | Pubmed ID: 18971326

Synthesis and evaluation of novel alpha-heteroaryl-phenylpropanoic acid derivatives as PPARalpha/gamma dual agonists.

Bioorganic & medicinal chemistry Oct, 2009 | Pubmed ID: 19783444

Efficacy and safety of mavrilimumab in subjects with rheumatoid arthritis.

Annals of the rheumatic diseases Sep, 2013 | Pubmed ID: 23234647

Recent developments in cell-based assays and stem cell technologies for botulinum neurotoxin research and drug discovery.

Expert review of molecular diagnostics Mar, 2014 | Pubmed ID: 24450833

Recent Advances in Botulinum Neurotoxin Inhibitor Development.

Current topics in medicinal chemistry Oct, 2014 | Pubmed ID: 25335887

INSTITUTIONS

Henry M. Jackson Foundation

US Army Medical Research Institute of Infectious Diseases

US Army Medical Research and Materiel Command (USAMRMC)

JOVE ARTICLES

A High Content Imaging Assay for Identification of Botulinum Neurotoxin Inhibitors

Krishna P. Kota^1,6,

Veronica Soloveva^2,6,7,

Laura M. Wanner^3,6,

Glenn Gomba^4,6,

Erkan Kiris^3,5,6,

Rekha G. Panchal⁶,

Christopher D. Kane^2,6,7,

Sina Bavari⁶

¹, Perkin Elmer Inc.,

², Henry M. Jackson Foundation,

³, The Geneva Foundation,

⁴, ORISE,

⁵, Frederick National Laboratory for Cancer Research,

⁶Division of Molecular and Translational Sciences, US Army Medical Research Institute of Infectious Diseases,

⁷DoD Biotechnology High Performance Computing Software Applications Institute (BHSAI), Telemedicine and Advanced Technology Research Center (TATRC), US Army Medical Research and Materiel Command (USAMRMC)

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