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Department of Neurology
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Caspase cascades in human immunodeficiency virus-associated neurodegeneration.
The Journal of neuroscience : the official journal of the Society for Neuroscience May, 2002 | Pubmed ID: 12019321
Polyglutamine-expanded ataxin-7 promotes non-cell-autonomous purkinje cell degeneration and displays proteolytic cleavage in ataxic transgenic mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience Jun, 2002 | Pubmed ID: 12077187
Microglia in human immunodeficiency virus-associated neurodegeneration.
Glia Nov, 2002 | Pubmed ID: 12379911
p53-dependent cell death signaling in neurons.
Neurochemical research Jan, 2003 | Pubmed ID: 12587660
Acyclovir responsive brain stem disease after the Ramsay Hunt syndrome.
Journal of the neurological sciences Jan, 2004 | Pubmed ID: 14675618
HIV associated neurodegeneration requires p53 in neurons and microglia.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology Jul, 2004 | Pubmed ID: 15155568
The multiple roles of p53 in the pathogenesis of HIV associated dementia.
Biochemical and biophysical research communications Jun, 2005 | Pubmed ID: 15865935
Association between carotid plaque characteristics and subsequent ischemic cerebrovascular events: a prospective assessment with MRI--initial results.
Stroke; a journal of cerebral circulation Mar, 2006 | Pubmed ID: 16469957
Bergmann glia expression of polyglutamine-expanded ataxin-7 produces neurodegeneration by impairing glutamate transport.
Nature neuroscience Oct, 2006 | Pubmed ID: 16936724
Predictors of carotid atherosclerotic plaque progression as measured by noninvasive magnetic resonance imaging.
Atherosclerosis Oct, 2007 | Pubmed ID: 16978632
Potential applications and limitations of proteomics in the study of neurological disease.
Archives of neurology Dec, 2006 | Pubmed ID: 17172608
Activation of the extrinsic caspase pathway in cultured cortical neurons requires p53-mediated down-regulation of the X-linked inhibitor of apoptosis protein to induce apoptosis.
Journal of neurochemistry Aug, 2007 | Pubmed ID: 17488272
Microglia biology in health and disease.
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology Jun, 2006 | Pubmed ID: 18040779
The glial response to CNS HIV infection includes p53 activation and increased expression of p53 target genes.
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology Dec, 2007 | Pubmed ID: 18040854
Molecular pathogenesis and cellular pathology of spinocerebellar ataxia type 7 neurodegeneration.
Cerebellum (London, England) , 2008 | Pubmed ID: 18418675
Polyglutamine-expanded androgen receptor truncation fragments activate a Bax-dependent apoptotic cascade mediated by DP5/Hrk.
The Journal of neuroscience : the official journal of the Society for Neuroscience Feb, 2009 | Pubmed ID: 19228953
Host and viral factors influencing the pathogenesis of HIV-associated neurocognitive disorders.
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology Jun, 2009 | Pubmed ID: 19373562
Autophagy activation and enhanced mitophagy characterize the Purkinje cells of pcd mice prior to neuronal death.
Molecular brain , 2009 | Pubmed ID: 19640278
Presenilin 2 is the predominant γ-secretase in microglia and modulates cytokine release.
PloS one , 2010 | Pubmed ID: 21206757
Transcription factor p53 influences microglial activation phenotype.
Glia Oct, 2011 | Pubmed ID: 21598312
Spinocerebellar ataxia type 7 cerebellar disease requires the coordinated action of mutant ataxin-7 in neurons and glia, and displays non-cell-autonomous bergmann glia degeneration.
The Journal of neuroscience : the official journal of the Society for Neuroscience Nov, 2011 | Pubmed ID: 22072678
Emerging roles of p53 in glial cell function in health and disease.
Glia Apr, 2012 | Pubmed ID: 22105777
University of Washington
Stephan J. Guyenet1,
Stephanie A. Furrer2,
Vincent M. Damian1,
Travis D. Baughan2,
Albert R. La Spada*,3,
Gwenn A. Garden*,2
1Department of Biochemistry, University of Washington,
2Department of Neurology, University of Washington,
3Division of Genetics, Departments of Pediatrics and Cellular and Molecular Medicine, and the Institute for Genomic Medicine, University of California, San Diego - Rady Children’s Hospital
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