Identification of Key Factors Regulating Self-renewal and Differentiation in EML Hematopoietic Precursor Cells by RNA-sequencing Analysis

Hematopoietic stem cells (HSCs) are used clinically for transplantation treatment to rebuild a patient&#39;s hematopoietic system in many diseases such as ...

The University of Texas Graduate School of Biomedical Sciences at Houston

&#x8336;&#x5C3A;&#x8816; obliqua picorna &#x6837;&#x75C5;&#x6BD2; (EoPV) &#x662F;&#x4E00;&#x79CD;&#x6606;&#x866B;&#x5E7C;&#x866B;&#x7684;&#x8336;&#x5C3A;&#x8816; &#xFF08;&#x8336;&#x5C3A;&#x8816; obliqua) &#x81F4;&#x547D;&#x9897;&#x7C92;&#x4F53;&#x611F;&#x67D3;&#x4F1A;&#x5BFC;&#x81F4;&#x7684; RNA &#x75C5;&#x6BD2;&#x3002;&#x5185;&#x90E8;&#x6838;&#x7CD6;&#x4F53;&#x8FDB;&#x5165;&#x4F4D;&#x70B9; (IRES) &#x4ECB;&#x5BFC; EoPV RNA &#x7FFB;&#x8BD1;&#x7684;&#x8D77;&#x59CB;&#x3002;&#x5728;&#x8FD9;&#x91CC;&#xFF0C;&#x987A;&#x6784;&#x9020;&#x7528;&#x4E8E;&#x68C0;&#x67E5; 5&#39; &#x975E;&#x7FFB;&#x8BD1;&#x7684;&#x533A; &#xFF08;&#x7F16;&#x7801;&#xFF09; &#x7684; EoPV IRES &#x6D3B;&#x52A8;&#x3002;EoPV 5&#39; UTR IRES &#x548C;&#x53E6;&#x4E00;&#x79CD;&#x6606;&#x866B;&#x75C5;&#x6BD2; IRES&#xFF0C;&#x677F;&#x7403;&#x9EBB;&#x75F9;&#x75C5;&#x6BD2;&#x57FA;&#x56E0;&#x533A;&#x57DF; IRES&#xFF0C;&#x8C03;&#x89E3;&#x5404;&#x79CD;&#x7FFB;&#x8BD1;&#x7CFB;&#x7EDF;&#x5185;&#x90E8;&#x7FFB;&#x8BD1;&#x8D77;&#x59CB;&#x7684;&#x80FD;&#x529B;&#x4E5F;&#x8FDB;&#x884C;&#x4E86;&#x6BD4;&#x8F83;&#x3002;&#x7ED3;&#x679C;&#x8868;&#x660E; EoPV IRES &#x8FD0;&#x4F5C;&#x9AD8;&#x6548;&#x4E0D;&#x4EC5;&#x5728;&#x54FA;&#x4E73;&#x52A8;&#x7269;&#x7EC6;&#x80DE;&#x7CFB;&#x7EDF;&#xFF0C;&#x800C;&#x4E14;&#x8FD8;&#x5728;&#x6606;&#x866B;&#x7EC6;&#x80DE;&#x7FFB;&#x8BD1;&#x7CFB;&#x7EDF;&#x3002;&#x7136;&#x800C;&#xFF0C;&#x5B83;&#x690D;&#x7269;&#x7EC6;&#x80DE;&#x7FFB;&#x8BD1;&#x7CFB;&#x7EDF;&#x8FD0;&#x4F5C;&#x6548;&#x7387;&#x4F4E;&#x4E0B;&#x3002;&#x8FD9;&#x9879;&#x7814;&#x7A76;&#x63ED;&#x793A;&#x4E86;&#x4E3B;&#x673A;&#x9996;&#x9009;&#x9879;&#x7684; EoPV IRES &#x548C;&#x91CD;&#x8981;&#x5DEE;&#x5F02; IRES &#x529F;&#x80FD;&#x4E4B;&#x95F4; EoPV IRES &#x548C;&#x5176;&#x4ED6;&#x7279;&#x70B9;&#x7C7B;&#x4F3C;&#x4E8E; picorna &#x7684;&#x6606;&#x866B;&#x75C5;&#x6BD2; IRESs&#x3002;

&#x8336;&#x5C3A;&#x8816; obliqua picorna &#x6837;&#x75C5;&#x6BD2; IRES &#x9A71;&#x52A8;&#x5185;&#x90E8;&#x542F;&#x52A8;&#x7535;&#x6C60;&#x7CFB;&#x7EDF;&#x4E2D;&#x7684;&#x7FFB;&#x8BD1;&#x6765;&#x81EA;&#x4E0D;&#x540C;&#x6765;&#x6E90;&#x3002;

Ectropis obliqua picorna-like virus (EoPV) is an insect RNA virus that causes a lethal granulosis infection of larvae of the tea looper (Ectropis obliqua). An internal ribosome entry site (IRES) mediates translation initiation of EoPV RNA. Here, bicistronic constructs were used to examine the 5' untranslated region (UTR) of EoPV for IRES activity. The capacities of the EoPV 5' UTR IRES and another insect virus IRES, the cricket paralysis virus intergenic region IRES, to mediate internal translation initiation in a variety of translation systems were also compared. The results demonstrated that the EoPV IRES functioned efficiently not only in mammalian cell-derived systems, but also in an insect cell-derived translation system. However, it functioned inefficiently in a plant cell-derived translation system. This study reveals the host preferences of the EoPV IRES and important differences in IRES function between the EoPV IRES and other characterized picorna-like insect viral IRESs.

Ectropis obliqua picorna-like virus IRES-driven internal initiation of translation in cell systems derived from different origins.

Ectropis obliqua picorna-like virus (EoPV) est un insecte de virus &agrave; ARN qui provoque une infection mortelle granulosis chez les larves de la fausse-arpenteuse du th&eacute; (Ectropis obliqua). Un site d&#39;entr&eacute;e de ribosome interne (IRES) intervient dans l&#39;initiation de la traduction de l&#39;ARN EoPV. Ici, les constructions bicistronique ont servi &agrave; &eacute;tudier la r&eacute;gion 5&#39; non traduite (UTR) de EoPV pour l&#39;activit&eacute; de l&#39;IRES. Les capacit&eacute;s de l&#39;IRES EoPV 5&#39; UTR et un autre virus d&#39;insecte IRES, la r&eacute;gion interg&eacute;nique virus paralysie cricket IRES, &agrave; la m&eacute;diation d&#39;initiation de la traduction interne dans une vari&eacute;t&eacute; de syst&egrave;mes de traduction ont aussi &eacute;t&eacute; compar&eacute;es. Les r&eacute;sultats ont d&eacute;montr&eacute; que l&#39;IRES EoPV fonctionnait efficacement non seulement dans les syst&egrave;mes de culture cellulaire chez les mammif&egrave;res, mais aussi dans un syst&egrave;me de traduction de culture cellulaire insectes. Toutefois, il a fonctionn&eacute; inefficacement dans un syst&egrave;me de traduction de cellules d&eacute;riv&eacute;es de plantes. Cette &eacute;tude r&eacute;v&egrave;le les pr&eacute;f&eacute;rences de l&#39;h&ocirc;te de l&#39;IRES de EoPV et des diff&eacute;rences importantes entre IRES fonctionner entre l&#39;IRES de EoPV et autre caract&eacute;ris&eacute; picorna-comme insecte IRESs virales.

Ectropis obliqua picorna-like virus pilot&eacute;e par l&#39;IRES interne initiation de la traduction dans les syst&egrave;mes cellulaires provenant de diff&eacute;rentes origines.

Ectropis Obliqua Picorna-wie Virus (EoPV) ist ein Insekt RNA-Virus, der eine t&ouml;dliche Granulosis Infektion der Larven von der Tee-Greifer (Ectropis Obliqua) bewirkt. Eine interne Ribosom Eintrag Site (IRES) vermittelt die &Uuml;bersetzung Einleitung EoPV RNA. Hier wurden Bicistronic Konstrukte verwendet, die 5&#39; un&uuml;bersetzte Region (UTR) EoPV f&uuml;r IRES Aktivit&auml;t zu untersuchen. Auch wurden die Kapazit&auml;ten des EoPV 5&#39; UTR IRES und anderen Insekten Virus IRES, Kricket Paralyse Virus intergenetischer Gebietes IRES, interne &Uuml;bersetzung Einleitung in eine Vielzahl von &Uuml;bersetzungssysteme vermitteln verglichen. Die Ergebnisse zeigten, dass die EoPV IRES effizient nicht nur in der S&auml;ugetier-Zelle-basierten Systeme, sondern auch ein Insekt Cell-derived &Uuml;bersetzungssystem funktionierte. Allerdings funktionierte es ineffizient in eine Zelle abgeleitete &Uuml;bersetzungssystem von Pflanzen. Diese Studie zeigt die Host-Pr&auml;ferenzen, der die EoPV IRES und deutliche Unterschiede bei der IRES-Funktion zwischen den EoPV IRES und anderen charakterisiert Picorna-&auml;hnliches Insekt virale IRESs.

Ectropis Obliqua Picorna-&auml;hnlichen Virus IRES-gesteuerte interne Initiation der Translation in der Zelle Systeme abgeleitet von unterschiedlicher Herkunft.

Ectropis obliqua simil-picorna virus (EoPV) &egrave; un insetto RNA virus che provoca un&#39;infezione letale granulosis delle larve di looper di t&egrave; (Ectropis obliqua). Una internal ribosome entry site (IRES) da intermediario iniziazione traduzione del RNA EoPV. Qui, bicistronic costrutti sono stati utilizzati per esaminare il 5&#39; untranslated regione (UTR) di EoPV per attivit&agrave; di IRES. La capacit&agrave; di EoPV 5&#39; UTR IRES e un altro insetto virus IRES, il cricket paralisi virus intergenic regione IRES, a mediare iniziazione traduzione interna in una variet&agrave; di sistemi di traduzione inoltre sono stati confrontati. I risultati hanno dimostrato che l&#39;IRES EoPV ha funzionato in modo efficace non solo nei sistemi di cellule derivate dei mammiferi, ma anche in un sistema di traduzione di cellule derivate dell&#39;insetto. Tuttavia, ha funzionato in modo inefficiente in un sistema di traduzione di cellule derivate dell&#39;impianto. Questo studio rivela le preferenze di host dell&#39;IRES EoPV e importanti differenze in IRES funzionano tra l&#39;IRES EoPV e altro caratterizzato picorna-come insetto IRESs virale.

Ectropis obliqua simil-picorna virus IRES-driven interna iniziazione della traduzione in sistemi cellulari derivati da origini diverse.

Ectropis &#x56DE; kakugo &#x30A6;&#x30A4;&#x30EB;&#x30B9; &#xFF08;EoPV&#xFF09; &#x6606;&#x866B;&#x8336;&#x30EB;&#x30FC;&#x30D1;&#x30FC; (Ectropis &#x56DE;) &#x306E;&#x5E7C;&#x866B;&#x306E;&#x81F4;&#x6B7B;&#x75C5;&#x611F;&#x67D3;&#x306E;&#x539F;&#x56E0;&#x3068; RNA &#x30A6;&#x30A4;&#x30EB;&#x30B9;&#x3067;&#x3059;&#x3002;&#x5185;&#x90E8;&#x30EA;&#x30DC;&#x30BE;&#x30FC;&#x30E0; &#x30A8;&#x30F3;&#x30C8;&#x30EA; &#x30B5;&#x30A4;&#x30C8; &#xFF08;IRES) EoPV RNA &#x306E;&#x7FFB;&#x8A33;&#x958B;&#x59CB;&#x3092;&#x4EF2;&#x4ECB;&#x3057;&#x307E;&#x3059;&#x3002;&#x3053;&#x3053;&#x3067;&#x306F;&#x3001;bicistronic &#x69CB;&#x9020;&#x4F53;&#x306F;&#x3001;5&#39; &#x975E;&#x7FFB;&#x8A33;&#x9818;&#x57DF; (UTR) EoPV &#x306E; IRES &#x6D3B;&#x6027;&#x306E;&#x691C;&#x8A0E;&#x306B;&#x4F7F;&#x7528;&#x3055;&#x308C;&#x307E;&#x3057;&#x305F;&#x3002;EoPV 5&#39; UTR IRES &#x304A;&#x3088;&#x3073;&#x5225;&#x306E;&#x6606;&#x866B;&#x30A6;&#x30A4;&#x30EB;&#x30B9; IRES&#x3001;&#x30B3;&#x30AA;&#x30ED;&#x30AE;&#x9EBB;&#x75FA;&#x30A6;&#x30A4;&#x30EB;&#x30B9;&#x907A;&#x4F1D;&#x5B50;&#x9593;&#x9818;&#x57DF; IRES&#x3001;&#x7FFB;&#x8A33;&#x30B7;&#x30B9;&#x30C6;&#x30E0;&#x306E;&#x3055;&#x307E;&#x3056;&#x307E;&#x306A;&#x5185;&#x90E8;&#x7FFB;&#x8A33;&#x958B;&#x59CB;&#x3092;&#x4EF2;&#x4ECB;&#x3059;&#x308B;&#x306E;&#x5BB9;&#x91CF;&#x3082;&#x6BD4;&#x8F03;&#x3057;&#x307E;&#x3057;&#x305F;&#x3002;EoPV IRES &#x7531;&#x6765;&#x7D30;&#x80DE;&#x3060;&#x3051;&#x3067;&#x306A;&#x304F;&#x52B9;&#x7387;&#x7684;&#x306B;&#x54FA;&#x4E73;&#x985E;&#x30B7;&#x30B9;&#x30C6;&#x30E0;&#x304C;&#x3001;&#x307E;&#x305F;&#x3001;&#x6606;&#x866B;&#x306E;&#x7D30;&#x80DE;&#x7531;&#x6765;&#x306E;&#x7FFB;&#x8A33;&#x30B7;&#x30B9;&#x30C6;&#x30E0;&#x306B;&#x4F5C;&#x7528;&#x3057;&#x305F;&#x3053;&#x3068;&#x304C;&#x793A;&#x5506;&#x3055;&#x308C;&#x307E;&#x3057;&#x305F;&#x3002;&#x305F;&#x3060;&#x3057;&#x3001;&#x305D;&#x308C;&#x306F;&#x975E;&#x52B9;&#x7387;&#x7684;&#x306B;&#x304A;&#x3051;&#x308B;&#x690D;&#x7269;&#x7D30;&#x80DE;&#x7531;&#x6765;&#x7FFB;&#x8A33;&#x30B7;&#x30B9;&#x30C6;&#x30E0;&#x3092;&#x6A5F;&#x80FD;&#x3057;&#x307E;&#x3057;&#x305F;&#x3002;&#x30DB;&#x30B9;&#x30C8;&#x74B0;&#x5883;&#x8A2D;&#x5B9A; EoPV IRES &#x306E;&#x3053;&#x306E;&#x7814;&#x7A76;&#x3092;&#x660E;&#x3089;&#x304B;&#x3057; IRES &#x306E;&#x91CD;&#x8981;&#x306A;&#x9055;&#x3044;&#x6A5F;&#x80FD; EoPV IRES &#x9593;&#x3068;&#x4ED6; kakugo &#x6606;&#x866B;&#x3092;&#x7279;&#x5FB4;&#x3068;&#x30A6;&#x30A4;&#x30EB;&#x30B9;&#x306E; IRESs&#x3002;

Ectropis &#x56DE; kakugo &#x30A6;&#x30A4;&#x30EB;&#x30B9; IRES &#x99C6;&#x52D5;&#x5185;&#x90E8;&#x306E;&#x958B;&#x59CB;&#x96FB;&#x6C60;&#x30B7;&#x30B9;&#x30C6;&#x30E0;&#x306B;&#x304A;&#x3051;&#x308B;&#x7FFB;&#x8A33;&#x306E;&#x7570;&#x306A;&#x308B;&#x8D77;&#x6E90;&#x304B;&#x3089;&#x6D3E;&#x751F;&#x3057;&#x307E;&#x3059;&#x3002;

Ectropis obliqua picorna &#xAC19;&#xC740; &#xBC14;&#xC774;&#xB7EC;&#xC2A4; (EoPV) &#xBC8C;&#xB808;&#xB97C; &#xCC28; &#xC790; &#xBC8C;&#xB808; (Ectropis obliqua) &#xC560;&#xBC8C;&#xB808;&#xC758; &#xCE58;&#xBA85;&#xC801;&#xC778; granulosis &#xAC10;&#xC5FC;&#xC744; &#xC77C;&#xC73C;&#xD0A4;&#xB294; RNA &#xBC14;&#xC774;&#xB7EC;&#xC2A4; &#xC774;&#xB2E4;. &#xB0B4;&#xBD80; &#xB9AC;&#xBCF4;&#xC19C; &#xD56D;&#xBAA9; &#xC0AC;&#xC774;&#xD2B8; (IRES) &#xC911;&#xC7AC; EoPV RNA&#xC758; &#xBC88;&#xC5ED; &#xAC1C;&#xC2DC;. &#xC5EC;&#xAE30;, bicistronic &#xAD6C;&#xBB38; &#xAC80;&#xC0AC; 5&#39; &#xB9DE;&#xC774; &#xC9C0;&#xC5ED; (UTR) Eopv&#xC758; IRES &#xD65C;&#xB3D9;&#xC5D0; &#xB300; &#xD55C; &#xC0AC;&#xC6A9; &#xD588;&#xB2E4;. EoPV 5&#39; UTR IRES&#xC640; &#xB2E4;&#xB978; &#xACE4;&#xCDA9; &#xBC14;&#xC774;&#xB7EC;&#xC2A4; IRES, &#xD06C;&#xB9AC;&#xCF13; &#xB9C8;&#xBE44; &#xBC14;&#xC774;&#xB7EC;&#xC2A4; intergenic &#xC9C0;&#xC5ED; IRES, &#xB2E4;&#xC591; &#xD55C; &#xBC88;&#xC5ED; &#xC2DC;&#xC2A4;&#xD15C;&#xC5D0;&#xC11C;&#xC5D0;&#xC11C; &#xB0B4;&#xBD80; &#xBC88;&#xC5ED; &#xAC1C;&#xC2DC; &#xC911;&#xC7AC;&#xC758; &#xC6A9;&#xB7C9; &#xBE44;&#xAD50;&#xB3C4; &#xD588;&#xB2E4;. &#xACB0;&#xACFC; EoPV IRES &#xC791;&#xC6A9; &#xBFD0;&#xB9CC; &#xC544;&#xB2C8;&#xB77C; &#xD6A8;&#xC728;&#xC801;&#xC73C;&#xB85C; &#xD3EC;&#xC720;&#xB958; &#xC138;&#xD3EC;&#xC5D0;&#xC11C; &#xD30C;&#xC0DD; &#xB41C; &#xC2DC;&#xC2A4;&#xD15C;&#xC5D0;&#xC11C;&#xC5D0;&#xC11C; &#xBFD0;&#xB9CC; &#xC544;&#xB2C8;&#xB77C; &#xACE4;&#xCDA9; &#xC138;&#xD3EC; &#xC720;&#xB798; &#xBC88;&#xC5ED; &#xC2DC;&#xC2A4;&#xD15C;&#xC5D0;&#xC11C;&#xC744; &#xC2DC;&#xC5F0; &#xD588;&#xB2E4;. &#xADF8;&#xB7EC;&#xB098;, &#xADF8;&#xAC83;&#xC740; &#xC2DD;&#xBB3C; &#xC138;&#xD3EC; &#xC720;&#xB798; &#xBC88;&#xC5ED; &#xC2DC;&#xC2A4;&#xD15C;&#xC5D0;&#xC11C; &#xD6A8;&#xC728;&#xC801;&#xC73C;&#xB85C; &#xC791;&#xC6A9; &#xD588;&#xB2E4;. &#xC774; &#xC5F0;&#xAD6C; &#xACB0;&#xACFC; &#xBC1D;&#xD600; EoPV IRES &#xD638;&#xC2A4;&#xD2B8; &#xD658;&#xACBD; &#xC124;&#xC815; &#xBC0F; IRES &#xC911;&#xC694; &#xD55C; &#xCC28;&#xC774;&#xC810;&#xC774; EoPV IRES &#xAC04;&#xC758; &#xAE30;&#xB2A5; &#xBC0F; &#xB2E4;&#xB978; &#xD2B9;&#xC9D5; picorna &#xAC19;&#xC740; &#xACE4;&#xCDA9; &#xBC14;&#xC774;&#xB7EC;&#xC2A4; &#xC131; IRESs.

Ectropis obliqua picorna &#xAC19;&#xC740; &#xBC14;&#xC774;&#xB7EC;&#xC2A4; &#xC140; &#xC2DC;&#xC2A4;&#xD15C;&#xC5D0;&#xC11C; &#xBC88;&#xC5ED;&#xC758; &#xB0B4;&#xBD80; &#xAC1C;&#xC2DC; IRES &#xAD6C;&#xB3D9; &#xB2E4;&#xB978; &#xADFC;&#xC6D0;&#xC5D0;&#xC11C; &#xD30C;&#xC0DD; &#xB41C;.

Ectropis obliqua por picornavirus-como virus (EoPV) es un insecto de virus de ARN que causa una infecci&oacute;n letal granulosis de larvas de la lanzadera de t&eacute; (Ectropis obliqua). Un sitio de entrada interna del ribosoma (IRES) media de iniciaci&oacute;n de la traducci&oacute;n del ARN EoPV. Aqu&iacute;, bicistronic construcciones fueron utilizadas para examinar el 5&#39; regi&oacute;n sin traducir (UTR) de EoPV para la actividad de IRES. Tambi&eacute;n se compararon las capacidades de la EoPV 5&#39; UTR IRES y otro virus de insectos IRES, la regi&oacute;n interg&eacute;nica virus IRES, de cricket par&aacute;lisis para mediar la iniciaci&oacute;n de la traducci&oacute;n interno en una variedad de sistemas de traducci&oacute;n. Los resultados demostraron que el IRES EoPV funcionado eficientemente no s&oacute;lo en sistemas derivados de c&eacute;lulas mam&iacute;feros, sino tambi&eacute;n en un sistema de traducci&oacute;n c&eacute;lula-derivados insectos. Sin embargo, funcion&oacute; ineficazmente en un sistema de traducci&oacute;n en c&eacute;lulas derivadas de la planta. Este estudio revela las preferencias de host de la EoPV IRES y diferencias importantes en IRES funci&oacute;n entre el IRES EoPV y otro caracterizado por picornavirus como insecto IRESs virales.

Ectropis obliqua por picornavirus-como virus basadas en IRES iniciaci&oacute;n interna de traducci&oacute;n en sistemas celulares derivados de diferentes or&iacute;genes.

Toxoplasmosis is an important parasitic disease worldwide and is related to certain psychiatric disorders and sterility. In the present study, serum samples from 882 female sterility patients and 107 pregnant-puerperant women were assayed for anti- T. gondii IgG antibodies using ELISA. The overall T. gondii seroprevalence was 14.8%. In the female sterility patients, 15.9% (140/882) were seropositive and, in the pregnant-puerperant women, 5.6% (6/107) were positive for anti- T. gondii IgG antibodies. There was a significant difference between the 2 groups ( P < 0.05). The samples were further divided into 5 groups based on age, but no significant difference was found among the 5 groups (P > 0.05). Results of the present study argue for more attention to prevention of T. gondii infection in the female population and, in particular, women of childbearing age.

Seroprevalence of Toxoplasma gondii infection in female sterility patients in China.

The merozoite surface protein (MSP)-1 of Plasmodium falciparum, the causative agent of malaria tropica, is considered to be a promising vaccine candidate. Although its stable cloning and expression has been difficult in the past, adenoviral vectors expressing the complex protein are described in the present study.

ΔE1 and high-capacity adenoviral vectors expressing full-length codon-optimized merozoite surface protein 1 for vaccination against Plasmodium falciparum.

Neuronal degeneration, in particular in the striatum, and the formation of nuclear and cytoplasmic inclusions are characteristics of Huntington's disease (HD) as a result of the expansion of a polyglutamine tract located close to the N-terminus of huntingtin (htt). Because of the large (10-kb) size of the htt cDNA, expression of full-length htt in primary neurons has proved difficult in the past.

Adenovirus vector-based in vitro neuronal cell model for Huntington's disease with human disease-like differential aggregation and degeneration.

We present a case report of secondary vaginal cancer after complete hysterectomy due to myoma that was complicated by low-grade cervical intraepithelial neoplasia (CIN I) and human papilloma virus (HPV) infection. After complete hysterectomy, the HPV DNA level in the vaginal tissue was obviously increased, and vaginal cancer was diagnosed 6 months later. We conclude that HPV infection can cause vaginal cancer after complete hysterectomy in cases complicated by CIN. Therefore, HPV should be regularly assessed during the postoperative follow-up period.

Shan Zong

The Vivian L. Smith Department of Neurosurgery,
Center for Stem Cell and Regenerative Medicine,
University of Texas Health Science Center,
The Vivian L. Smith Department of Neurosurgery, Center for Stem Cell and Regenerative Medicine, University of Texas Health Science Center

The University of Texas Graduate School of Biomedical Sciences at Houston

Identification of Key Factors Regulating Self-renewal and Differentiation in EML Hematopoietic Precursor Cells by RNA-sequencing Analysis