Dan E. Berkowitz

Impaired pulmonary artery contractile responses in a rat model of microgravity: role of nitric oxide.

Nitric oxide regulates the heart by spatial confinement of nitric oxide synthase isoforms.

Estrogen has opposing effects on vascular reactivity in obese, insulin-resistant male Zucker rats.

Nitric oxide regulation of myocardial contractility and calcium cycling: independent impact of neuronal and endothelial nitric oxide synthases.

Disruption of leptin signaling contributes to cardiac hypertrophy independently of body weight in mice.

Arginase reciprocally regulates nitric oxide synthase activity and contributes to endothelial dysfunction in aging blood vessels.

Enhanced vasodilatory responses to milrinone in catecholamine-precontracted small pulmonary arteries.

Critical role for the alpha-1B adrenergic receptor at the sympathetic neuroeffector junction.

Apurinic/apyrimidinic endonuclease 1 regulates endothelial NO production and vascular tone.

Neuronal nitric oxide synthase negatively regulates xanthine oxidoreductase inhibition of cardiac excitation-contraction coupling.

Leptin repletion restores depressed {beta}-adrenergic contractility in ob/ob mice independently of cardiac hypertrophy.

Simulated microgravity produces attenuated baroreflex-mediated pressor, chronotropic, and inotropic responses in mice.

P66shc regulates endothelial NO production and endothelium-dependent vasorelaxation: implications for age-associated vascular dysfunction.

Cardiac myocyte apoptosis is associated with increased DNA damage and decreased survival in murine models of obesity.

Knockdown of arginase I restores NO signaling in the vasculature of old rats.

Arginase modulates myocardial contractility by a nitric oxide synthase 1-dependent mechanism.

Activation of the cardiac ciliary neurotrophic factor receptor reverses left ventricular hypertrophy in leptin-deficient and leptin-resistant obesity.

Oxidized low-density lipoprotein-dependent endothelial arginase II activation contributes to impaired nitric oxide signaling.

Microgravity-induced changes in aortic stiffness and their role in orthostatic intolerance.

Impaired shear stress-induced nitric oxide production through decreased NOS phosphorylation contributes to age-related vascular stiffness.

Myocyte nitroso-redox imbalance in sepsis: NO simple answer.

Single exposure gamma-irradiation amplifies xanthine oxidase activity and induces endothelial dysfunction in rat aorta.

Microgravity and cardiac atrophy: no sex discrimination.

Inducible NO synthase dependent S-nitrosylation and activation of arginase1 contribute to age-related endothelial dysfunction.

Pulse pressure is an age-independent predictor of stroke development after cardiac surgery.

Mitochondrial arginase II constrains endothelial NOS-3 activity.

Endothelial arginase II: a novel target for the treatment of atherosclerosis.

Selective fluorescent labeling of S-nitrosothiols (S-FLOS): a novel method for studying S-nitrosation.

Arginase and vascular aging.

Perioperative blood pressure management: does central vascular stiffness matter?

Increased oxidant activity mediates vascular dysfunction in vibration injury.

Sildenafil inhibits superoxide formation and prevents endothelial dysfunction in a mouse model of secondhand smoke induced erectile dysfunction.

Simulated microgravity-induced aortic remodeling.

Arginase inhibition restores NOS coupling and reverses endothelial dysfunction and vascular stiffness in old rats.

Dietary inhibition of xanthine oxidase attenuates radiation-induced endothelial dysfunction in rat aorta.

Single exposure to radiation produces early anti-angiogenic effects in mouse aorta.

Decreased S-nitrosylation of tissue transglutaminase contributes to age-related increases in vascular stiffness.

Early changes in vasoreactivity after simulated microgravity are due to an upregulation of the endothelium-dependent nitric oxide/cGMP pathway.

Increased endothelial exocytosis and generation of endothelin-1 contributes to constriction of aged arteries.

β2-adrenergic receptor-coupled phosphoinositide 3-kinase constrains cAMP-dependent increases in cardiac inotropy through phosphodiesterase 4 activation.

OxLDL-dependent activation of arginase II is dependent on the LOX-1 receptor and downstream RhoA signaling.

Restoring leptin signaling reduces hyperlipidemia and improves vascular stiffness induced by chronic intermittent hypoxia.

Phosphodiesterase-5A (PDE5A) is localized to the endothelial caveolae and modulates NOS3 activity.

Review article: implications of vascular aging.

Oral atorvastatin therapy restores cutaneous microvascular function by decreasing arginase activity in hypercholesterolaemic humans.

S-nitrosation of arginase 1 requires direct interaction with inducible nitric oxide synthase.

HZE ⁵⁶Fe-ion irradiation induces endothelial dysfunction in rat aorta: role of xanthine oxidase.

Vascular stiffness and increased pulse pressure in the aging cardiovascular system.

Endothelial arginase II and atherosclerosis.

Upregulation of inducible nitric oxide synthase contributes to attenuated cutaneous vasodilation in essential hypertensive humans.

Hydrogen sulfide as endothelium-derived hyperpolarizing factor sulfhydrates potassium channels.

Nitric oxide regulates tissue transglutaminase localization and function in the vasculature.

Nitric oxide regulates non-classical secretion of tissue transglutaminase.

Upregulation of arginase-II contributes to decreased age-related myocardial contractile reserve.

Hydrogen sulfide decreases reactive oxygen in a model of lung transplantation.

Chronic oral administration of the arginase inhibitor 2(S)-amino-6-boronohexanoic acid (ABH) improves erectile function in aged rats.

Endothelial nitric oxide synthase mediates cutaneous vasodilation during local heating and is attenuated in middle-aged human skin.

Alagebrium in combination with exercise ameliorates age-associated ventricular and vascular stiffness.

Inhaled hydrogen sulfide improves graft function in an experimental model of lung transplantation.

Increased arginase II activity contributes to endothelial dysfunction through endothelial nitric oxide synthase uncoupling in aged mice.

Vasopressin-mediated enhancement of adrenergic vasoconstriction involves both the tyrosine kinase and the protein kinase C pathways.

Interleukin 10 knockout frail mice develop cardiac and vascular dysfunction with increased age.

A physiologic and biochemical profile of clinically rejected lungs on a normothermic ex vivo lung perfusion platform.

Decreased erythrocyte deformability after transfusion and the effects of erythrocyte storage duration.

Sildenafil citrate protects skeletal muscle of ischemia-reperfusion injury: immunohistochemical study in rat model.

Nitroprusside inhibits calcium-induced impairment of red blood cell deformability.

Sildenafil citrate-restored eNOS and PDE5 regulation in sickle cell mouse penis prevents priapism via control of oxidative/nitrosative stress.

Increased tissue transglutaminase activity contributes to central vascular stiffness in eNOS knockout mice.

Arginase II: atherogenesis beyond enzyme activity.

Development of novel arginase inhibitors for therapy of endothelial dysfunction.

Contribution of arginase activation to vascular dysfunction in cigarette smoking.

New insights provided by a comparison of impaired deformability with erythrocyte oxidative stress for sickle cell disease.

Effect of isoflurane on myocardial energetic and oxidative stress in cardiac muscle from Zucker diabetic fatty rat.

Exercise, vascular stiffness, and tissue transglutaminase.

Impaired red blood cell deformability after transfusion of stored allogeneic blood but not autologous salvaged blood in cardiac surgery patients.

OxLDL triggers retrograde translocation of arginase2 in aortic endothelial cells via ROCK and mitochondrial processing peptidase.

Melanopsin mediates light-dependent relaxation in blood vessels.