Kostas Pantopoulos

Activation of iron regulatory protein-1 by oxidative stress.

Redox control of iron regulatory proteins.

Conditional derepression of ferritin synthesis in cells expressing a constitutive IRP1 mutant.

The prolyl 4-hydroxylase inhibitor ethyl-3,4-dihydroxybenzoate generates effective iron deficiency in cultured cells.

The haemochromatosis protein HFE induces an apparent iron-deficient phenotype in H1299 cells that is not corrected by co-expression of beta 2-microglobulin.

Myeloperoxidase-derived hypochlorous acid antagonizes the oxidative stress-mediated activation of iron regulatory protein 1.

A phosphomimetic mutation at Ser-138 renders iron regulatory protein 1 sensitive to iron-dependent degradation.

Iron-mediated degradation of IRP2, an unexpected pathway involving a 2-oxoglutarate-dependent oxygenase activity.

ANP-induced decrease of iron regulatory protein activity is independent of HO-1 induction.

Iron metabolism and the IRE/IRP regulatory system: an update.

Oxidation-induced ferritin turnover in microglial cells: role of proteasome.

IRP1 Ser-711 is a phosphorylation site, critical for regulation of RNA-binding and aconitase activities.

Iron inactivates the RNA polymerase NS5B and suppresses subgenomic replication of hepatitis C Virus.

Nitric oxide inhibits the degradation of IRP2.

The pathway for IRP2 degradation involving 2-oxoglutarate-dependent oxygenase(s) does not require the E3 ubiquitin ligase activity of pVHL.

Inhibition of transferrin receptor 1 transcription by a cell density response element.

Hepcidin generated by hepatoma cells inhibits iron export from co-cultured THP1 monocytes.

Sodium nitroprusside promotes IRP2 degradation via an increase in intracellular iron and in the absence of S nitrosylation at C178.

Alcohol metabolism-mediated oxidative stress down-regulates hepcidin transcription and leads to increased duodenal iron transporter expression.

In vivo tumor growth is inhibited by cytosolic iron deprivation caused by the expression of mitochondrial ferritin.

Overexpression of iron regulatory protein 1 suppresses growth of tumor xenografts.

Iron-dependent degradation of apo-IRP1 by the ubiquitin-proteasome pathway.

Expression of the subgenomic hepatitis C virus replicon alters iron homeostasis in Huh7 cells.

Sustained hydrogen peroxide induces iron uptake by transferrin receptor-1 independent of the iron regulatory protein/iron-responsive element network.

Human iron regulatory protein 2 is easily cleaved in its specific domain: consequences for the haem binding properties of the protein.

Iron-dependent degradation of IRP2 requires its C-terminal region and IRP structural integrity.

Insights on regulation and function of the iron regulatory protein 1 (IRP1).

Oxidative stress and iron homeostasis: mechanistic and health aspects.

Iron regulatory and bactericidal properties of human recombinant hepcidin expressed in Pichia pastoris.

A role for lysosomes in the turnover of human iron regulatory protein 2.

Function of the hemochromatosis protein HFE: Lessons from animal models.

Small-molecule inhibitors of HIF-2a translation link its 5'UTR iron-responsive element to oxygen sensing.

HO-1-mediated macroautophagy: a mechanism for unregulated iron deposition in aging and degenerating neural tissues.

Iron absorption and distribution in TNF(DeltaARE/+) mice, a model of chronic inflammation.

Tumorigenic properties of iron regulatory protein 2 (IRP2) mediated by its specific 73-amino acids insert.

Iron inhibits replication of infectious hepatitis C virus in permissive Huh7.5.1 cells.

eIF2{alpha} Kinase PKR modulates the hypoxic response by Stat3-dependent transcriptional suppression of HIF-1{alpha}.

Redox control of iron regulatory protein 2 stability.

Regulation of cellular iron metabolism.

Conditional disruption of mouse HFE2 gene: maintenance of systemic iron homeostasis requires hepatic but not skeletal muscle hemojuvelin.

Disorders associated with systemic or local iron overload: from pathophysiology to clinical practice.

Accelerated CCl4-induced liver fibrosis in Hjv-/- mice, associated with an oxidative burst and precocious profibrogenic gene expression.

Regulation of iron transport and the role of transferrin.

Synthesis of biocompatible poly(ɛ-caprolactone)- block-poly(propylene adipate) copolymers appropriate for drug nanoencapsulation in the form of core-shell nanoparticles.

Alternative ferritin mRNA translation via internal initiation.

Mechanisms of mammalian iron homeostasis.

Differences in activation of mouse hepcidin by dietary iron and parenterally administered iron dextran: compartmentalization is critical for iron sensing.

Unregulated brain iron deposition in transgenic mice over-expressing HMOX1 in the astrocytic compartment.

Oxygen-dependent secretion of a bioactive hepcidin-GFP chimera.

IRP1 regulates erythropoiesis and systemic iron homeostasis by controlling HIF2α mRNA translation.

Hepatitis C virus infection causes iron deficiency in Huh7.5.1 cells.

Iron-dependent regulation of hepcidin in Hjv-/- mice: evidence that hemojuvelin is dispensable for sensing body iron levels.

The IRP/IRE system in vivo: insights from mouse models.

Chronic hepatitis C and liver fibrosis.

NTBI unveiled by chelatable fluorescent beads.