Lady Davis Institute for Medical Research
Kostas Pantopoulos has not added Biography.
If you are Kostas Pantopoulos and would like to personalize this page please email our Author Liaison for assistance.
Activation of iron regulatory protein-1 by oxidative stress.
Methods in enzymology , 2002 | Pubmed ID: 11885287
Redox control of iron regulatory proteins.
Redox report : communications in free radical research , 2002 | Pubmed ID: 11981450
Conditional derepression of ferritin synthesis in cells expressing a constitutive IRP1 mutant.
Molecular and cellular biology Jul, 2002 | Pubmed ID: 12052872
The prolyl 4-hydroxylase inhibitor ethyl-3,4-dihydroxybenzoate generates effective iron deficiency in cultured cells.
FEBS letters Oct, 2002 | Pubmed ID: 12372619
The haemochromatosis protein HFE induces an apparent iron-deficient phenotype in H1299 cells that is not corrected by co-expression of beta 2-microglobulin.
The Biochemical journal Mar, 2003 | Pubmed ID: 12464008
Myeloperoxidase-derived hypochlorous acid antagonizes the oxidative stress-mediated activation of iron regulatory protein 1.
The Journal of biological chemistry Oct, 2003 | Pubmed ID: 12888561
A phosphomimetic mutation at Ser-138 renders iron regulatory protein 1 sensitive to iron-dependent degradation.
Molecular and cellular biology Oct, 2003 | Pubmed ID: 12972614
Iron-mediated degradation of IRP2, an unexpected pathway involving a 2-oxoglutarate-dependent oxygenase activity.
Molecular and cellular biology Feb, 2004 | Pubmed ID: 14729944
ANP-induced decrease of iron regulatory protein activity is independent of HO-1 induction.
American journal of physiology. Gastrointestinal and liver physiology Sep, 2004 | Pubmed ID: 15087280
Iron metabolism and the IRE/IRP regulatory system: an update.
Annals of the New York Academy of Sciences Mar, 2004 | Pubmed ID: 15105251
Oxidation-induced ferritin turnover in microglial cells: role of proteasome.
Free radical biology & medicine Jan, 2005 | Pubmed ID: 15607911
IRP1 Ser-711 is a phosphorylation site, critical for regulation of RNA-binding and aconitase activities.
The Biochemical journal May, 2005 | Pubmed ID: 15636585
Iron inactivates the RNA polymerase NS5B and suppresses subgenomic replication of hepatitis C Virus.
The Journal of biological chemistry Mar, 2005 | Pubmed ID: 15637067
Nitric oxide inhibits the degradation of IRP2.
Molecular and cellular biology Feb, 2005 | Pubmed ID: 15684386
The pathway for IRP2 degradation involving 2-oxoglutarate-dependent oxygenase(s) does not require the E3 ubiquitin ligase activity of pVHL.
Biochimica et biophysica acta Mar, 2005 | Pubmed ID: 15777842
Inhibition of transferrin receptor 1 transcription by a cell density response element.
The Biochemical journal Dec, 2005 | Pubmed ID: 16092918
Hepcidin generated by hepatoma cells inhibits iron export from co-cultured THP1 monocytes.
Journal of hepatology Jun, 2006 | Pubmed ID: 16460831
Sodium nitroprusside promotes IRP2 degradation via an increase in intracellular iron and in the absence of S nitrosylation at C178.
Molecular and cellular biology Mar, 2006 | Pubmed ID: 16479012
Alcohol metabolism-mediated oxidative stress down-regulates hepcidin transcription and leads to increased duodenal iron transporter expression.
The Journal of biological chemistry Aug, 2006 | Pubmed ID: 16737972
In vivo tumor growth is inhibited by cytosolic iron deprivation caused by the expression of mitochondrial ferritin.
Blood Oct, 2006 | Pubmed ID: 16757684
Overexpression of iron regulatory protein 1 suppresses growth of tumor xenografts.
Carcinogenesis Apr, 2007 | Pubmed ID: 17127713
Iron-dependent degradation of apo-IRP1 by the ubiquitin-proteasome pathway.
Molecular and cellular biology Apr, 2007 | Pubmed ID: 17242182
Expression of the subgenomic hepatitis C virus replicon alters iron homeostasis in Huh7 cells.
Journal of hepatology Jul, 2007 | Pubmed ID: 17399844
Sustained hydrogen peroxide induces iron uptake by transferrin receptor-1 independent of the iron regulatory protein/iron-responsive element network.
The Journal of biological chemistry Jul, 2007 | Pubmed ID: 17517884
Human iron regulatory protein 2 is easily cleaved in its specific domain: consequences for the haem binding properties of the protein.
The Biochemical journal Dec, 2007 | Pubmed ID: 17760563
Iron-dependent degradation of IRP2 requires its C-terminal region and IRP structural integrity.
BMC molecular biology , 2008 | Pubmed ID: 18226225
Insights on regulation and function of the iron regulatory protein 1 (IRP1).
Hemoglobin , 2008 | Pubmed ID: 18274988
Oxidative stress and iron homeostasis: mechanistic and health aspects.
Critical reviews in clinical laboratory sciences , 2008 | Pubmed ID: 18293179
Iron regulatory and bactericidal properties of human recombinant hepcidin expressed in Pichia pastoris.
Biochimie May, 2008 | Pubmed ID: 18295606
A role for lysosomes in the turnover of human iron regulatory protein 2.
The international journal of biochemistry & cell biology , 2008 | Pubmed ID: 18582596
Function of the hemochromatosis protein HFE: Lessons from animal models.
World journal of gastroenterology : WJG Dec, 2008 | Pubmed ID: 19058322
Small-molecule inhibitors of HIF-2a translation link its 5'UTR iron-responsive element to oxygen sensing.
Molecular cell Dec, 2008 | Pubmed ID: 19111663
HO-1-mediated macroautophagy: a mechanism for unregulated iron deposition in aging and degenerating neural tissues.
Journal of neurochemistry May, 2009 | Pubmed ID: 19250338
Iron absorption and distribution in TNF(DeltaARE/+) mice, a model of chronic inflammation.
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) Jan, 2010 | Pubmed ID: 20122582
Tumorigenic properties of iron regulatory protein 2 (IRP2) mediated by its specific 73-amino acids insert.
PloS one , 2010 | Pubmed ID: 20405006
Iron inhibits replication of infectious hepatitis C virus in permissive Huh7.5.1 cells.
Journal of hepatology Dec, 2010 | Pubmed ID: 20813419
eIF2{alpha} Kinase PKR modulates the hypoxic response by Stat3-dependent transcriptional suppression of HIF-1{alpha}.
Cancer research Oct, 2010 | Pubmed ID: 20924113
Redox control of iron regulatory protein 2 stability.
FEBS letters Feb, 2011 | Pubmed ID: 21281640
Regulation of cellular iron metabolism.
The Biochemical journal Mar, 2011 | Pubmed ID: 21348856
Conditional disruption of mouse HFE2 gene: maintenance of systemic iron homeostasis requires hepatic but not skeletal muscle hemojuvelin.
Hepatology (Baltimore, Md.) Nov, 2011 | Pubmed ID: 21748766
Disorders associated with systemic or local iron overload: from pathophysiology to clinical practice.
Metallomics : integrated biometal science Oct, 2011 | Pubmed ID: 21901209
Accelerated CCl4-induced liver fibrosis in Hjv-/- mice, associated with an oxidative burst and precocious profibrogenic gene expression.
PloS one , 2011 | Pubmed ID: 21966437
Regulation of iron transport and the role of transferrin.
Biochimica et biophysica acta Mar, 2012 | Pubmed ID: 22085723
Synthesis of biocompatible poly(ɛ-caprolactone)- block-poly(propylene adipate) copolymers appropriate for drug nanoencapsulation in the form of core-shell nanoparticles.
International journal of nanomedicine , 2011 | Pubmed ID: 22162656
Alternative ferritin mRNA translation via internal initiation.
RNA (New York, N.Y.) Mar, 2012 | Pubmed ID: 22271759
Mechanisms of mammalian iron homeostasis.
Biochemistry Jul, 2012 | Pubmed ID: 22703180
Differences in activation of mouse hepcidin by dietary iron and parenterally administered iron dextran: compartmentalization is critical for iron sensing.
Journal of molecular medicine (Berlin, Germany) Jan, 2013 | Pubmed ID: 22847740
Unregulated brain iron deposition in transgenic mice over-expressing HMOX1 in the astrocytic compartment.
Journal of neurochemistry Oct, 2012 | Pubmed ID: 22881289
Oxygen-dependent secretion of a bioactive hepcidin-GFP chimera.
Biochemical and biophysical research communications Jun, 2013 | Pubmed ID: 23665013
IRP1 regulates erythropoiesis and systemic iron homeostasis by controlling HIF2α mRNA translation.
Blood Aug, 2013 | Pubmed ID: 23777768
Hepatitis C virus infection causes iron deficiency in Huh7.5.1 cells.
PloS one , 2013 | Pubmed ID: 24349485
Iron-dependent regulation of hepcidin in Hjv-/- mice: evidence that hemojuvelin is dispensable for sensing body iron levels.
PloS one , 2014 | Pubmed ID: 24409331
The IRP/IRE system in vivo: insights from mouse models.
Frontiers in pharmacology , 2014 | Pubmed ID: 25120486
Chronic hepatitis C and liver fibrosis.
World journal of gastroenterology : WJG Aug, 2014 | Pubmed ID: 25170193
NTBI unveiled by chelatable fluorescent beads.
The Biochemical journal Nov, 2014 | Pubmed ID: 25301074
SOBRE A JoVE
Copyright © 2024 MyJoVE Corporation. Todos os direitos reservados