Andreas Vogt

The antisignaling agent SC-alpha alpha delta 9, 4-(benzyl-(2-[(2,5-diphenyloxazole-4-carbonyl)amino]ethyl)carbamoyl)- 2-decanoylaminobutyric acid, is a structurally unique phospholipid analogue with phospholipase C inhibitory activity.

Cell-active dual specificity phosphatase inhibitors identified by high-content screening.

Activation of the Raf-1/MEK/Erk kinase pathway by a novel Cdc25 inhibitor in human prostate cancer cells.

A scalable high-content cytotoxicity assay insensitive to changes in mitochondrial metabolic activity.

Discovery and characterization of novel small molecule inhibitors of human Cdc25B dual specificity phosphatase.

The benzo[c]phenanthridine alkaloid, sanguinarine, is a selective, cell-active inhibitor of mitogen-activated protein kinase phosphatase-1.

Rhodopsin patterning in central photoreceptor cells of the blowfly Calliphora vicina: cloning and characterization of Calliphora rhodopsins Rh3, Rh5 and Rh6.

Dual specificity protein phosphatases: therapeutic targets for cancer and Alzheimer's disease.

Chemical complementation: a definitive phenotypic strategy for identifying small molecule inhibitors of elusive cellular targets.

Tubulin assembly, taxoid site binding, and cellular effects of the microtubule-stabilizing agent dictyostatin.

Structure-based design of imidazole-containing peptidomimetic inhibitors of protein farnesyltransferase.

Cellular analysis of disorazole C and structure-activity relationship of analogs of the natural product.

Novel benzofuran inhibitors of human mitogen-activated protein kinase phosphatase-1.

Postoperative colonic motility after tropisetron and a standardized meal in patients undergoing conventional colorectal surgery.

Discovery of protein kinase phosphatase inhibitors.

Regulator of G-protein signalling 3 redirects prototypical Gi-coupled receptors from Rac1 to RhoA activation.

Implementation of high-content assay for inhibitors of mitogen-activated protein kinase phosphatases.

Total synthesis and biological evaluation of C16 analogs of (-)-dictyostatin.

Structure-activity and high-content imaging analyses of novel tubulysins.

Sphingosine-1-phosphate and endothelin-1 induce the expression of rgs16 protein in cardiac myocytes by transcriptional activation of the rgs16 gene.

Reduction of airspace after lung resection through controlled paralysis of the diaphragm.

Cell-based and biochemical structure-activity analyses of analogs of the microtubule stabilizer dictyostatin.

A cell-active inhibitor of mitogen-activated protein kinase phosphatases restores paclitaxel-induced apoptosis in dexamethasone-protected cancer cells.

Synthesis and biological evaluation of (-)-dictyostatin and stereoisomers.

Human rhomboid family-1 gene RHBDF1 participates in GPCR-mediated transactivation of EGFR growth signals in head and neck squamous cancer cells.

Automated image-based phenotypic analysis in zebrafish embryos.

Automatic algorithm for monitoring systolic pressure variation and difference in pulse pressure.

Evaluation of physical and mental recovery status after elective liver resection.

Crossover comparison of the laryngeal mask supreme and the i-gel in simulated difficult airway scenario in anesthetized patients.

Peri-operative adrenocortical response to low-dose (1 microg) ACTH and relation to postoperative complications in patients undergoing elective abdominal surgery.

Zebrafish chemical screening reveals an inhibitor of Dusp6 that expands cardiac cell lineages.

Meayamycin inhibits pre-messenger RNA splicing and exhibits picomolar activity against multidrug-resistant cells.

High-content analysis of cancer-cell-specific apoptosis and inhibition of in vivo angiogenesis by synthetic (-)-pironetin and analogs.

An unusual case of self-defense.

A comparison of micropore membrane inlet mass spectrometry-derived pulmonary shunt measurement with Riley shunt in a porcine model.

Identifying a resistance determinant for the antimitotic natural products disorazole C1 and A1.

Observation of ventilation-induced Spo(2) oscillations in pigs: first step to noninvasive detection of cyclic recruitment of atelectasis?

Streamlined syntheses of (-)-dictyostatin, 16-desmethyl-25,26-dihydrodictyostatin, and 6-epi-16-desmethyl-25,26-dihydrodictyostatin.

Emergency skill training--a randomized controlled study on the effectiveness of the 4-stage approach compared to traditional clinical teaching.

A simplified synthesis of novel dictyostatin analogues with in vitro activity against epothilone B-resistant cells and antiangiogenic activity in zebrafish embryos.

Disruption of intraflagellar protein transport in photoreceptor cilia causes Leber congenital amaurosis in humans and mice.

Evaluation of spontaneous propulsive movement as a screening tool to detect rescue of Parkinsonism phenotypes in zebrafish models.

Rapid proteomic remodeling of cardiac tissue caused by total body ionizing radiation.

A high-content screening assay in transgenic zebrafish identifies two novel activators of fgf signaling.

Efficient syntheses of 25,26-dihydrodictyostatin and 25,26-dihydro-6-epi-dictyostatin, two potent new microtubule-stabilizing agents.

Structural and functional protein network analyses predict novel signaling functions for rhodopsin.

A high-throughput FRET-based assay for determination of Atg4 activity.