Billy W. Day

Synthesis and biological evaluation of structurally highly modified analogues of the antimitotic natural product curacin A.

Discodermolide/Dictyostatin hybrids: synthesis and biological evaluation.

The antisignaling agent SC-alpha alpha delta 9, 4-(benzyl-(2-[(2,5-diphenyloxazole-4-carbonyl)amino]ethyl)carbamoyl)- 2-decanoylaminobutyric acid, is a structurally unique phospholipid analogue with phospholipase C inhibitory activity.

Synthesis and high content cell-based profiling of simplified analogues of the microtubule stabilizer (+)-discodermolide.

Simplified discodermolide analogues: synthesis and biological evaluation of 4-epi-7-dehydroxy-14,16-didemethyl-(+)-discodermolides as microtubule-stabilizing agents.

Synthesis and biological assessment of simplified analogues of the potent microtubule stabilizer (+)-discodermolide.

Identification of structural components associated with cytostatic activity in MCF-7 but not in MDA-MB-231 cells.

Altered levels and regulation of stathmin in paclitaxel-resistant ovarian cancer cells.

Chemistry and biology of curacin A.

Detection of conjugated C16 PUFAs in rat tissues as possible partial beta-oxidation products of naturally occurring conjugated linoleic acid and its metabolites.

Inhibition of estrogen receptor alpha-mediated transcription by antiestrogenic 1,1-dichloro-2,2,3-triarylcyclopropanes.

Small molecule modulators of endogenous and co-chaperone-stimulated Hsp70 ATPase activity.

New antiestrogens from a library screen of homoallylic amides, allylic amides, and C-cyclopropylalkylamides.

CoMFA, HQSAR and molecular docking studies of butitaxel analogues with beta-tubulin.

Proteomic characterization of harvested pseudopodia with differential gel electrophoresis and specific antibodies.

Microwave-assisted "libraries from libraries" approach toward the synthesis of allyl- and C-cyclopropylalkylamides.

HPRT gene alterations in umbilical cord blood T-lymphocytes in newborns of mothers exposed to tobacco smoke during pregnancy.

A pregnane X receptor agonist with unique species-dependent stereoselectivity and its implications in drug development.

Synthesis and biological evaluation of (-)-16-normethyldictyostatin: a potent analogue of (-)-dictyostatin.

Redox regulation of Cdc25B by cell-active quinolinediones.

A common pharmacophore for a diverse set of colchicine site inhibitors using a structure-based approach.

Orphan nuclear receptor pregnane X receptor sensitizes oxidative stress responses in transgenic mice and cancerous cells.

Rac1 leads to phosphorylation-dependent increase in stability of the p66shc adaptor protein: role in Rac1-induced oxidative stress.

Tubulin assembly, taxoid site binding, and cellular effects of the microtubule-stabilizing agent dictyostatin.

Systems cell biology knowledge created from high content screening.

Brisk production of nitric oxide and associated formation of S-nitrosothiols in early hemorrhage.

Fluorous mixture synthesis of (-)-dictyostatin and three stereoisomers.

Altered expression and localization of creatine kinase B, heterogeneous nuclear ribonucleoprotein F, and high mobility group box 1 protein in the nuclear matrix associated with colon cancer.

Synthesis and biological evaluation of purealin and analogues as cytoplasmic dynein heavy chain inhibitors.

Myeloperoxidase-catalyzed metabolism of etoposide to its quinone and glutathione adduct forms in HL60 cells.

Synergistic effects of peloruside A and laulimalide with taxoid site drugs, but not with each other, on tubulin assembly.

Albumin marks pseudopodia of astrocytoma cells responding to hepatocyte growth factor or serum.

Production and characterization of monoclonal antibodies against ochratoxin B.

Cyclostreptin binds covalently to microtubule pores and lumenal taxoid binding sites.

Genotoxicity assessed by the comet and GPA assays following in vitro exposure of human lymphoblastoid cells (H9) or perinatal exposure of mother-child pairs to AZT or AZT-3TC.

Total synthesis and biological evaluation of C16 analogs of (-)-dictyostatin.

New opportunities for pregnane X receptor (PXR) targeting in drug development. lessons from Enantio- and species-specific PXR ligands identified from a discovery library of amino acid analogues.

Structure-activity and high-content imaging analyses of novel tubulysins.

Cell-based and biochemical structure-activity analyses of analogs of the microtubule stabilizer dictyostatin.

Pyrimidinone-peptoid hybrid molecules with distinct effects on molecular chaperone function and cell proliferation.

Tubulin-perturbing naphthoquinone spiroketals.

(Z)-1,1-Dichloro-2-(4-methoxyphenyl)-3-phenylcyclopropane induces concentration-dependent growth inhibition, apoptosis, and coordinates regulation of apoptotic genes in TRAMP cells.

Mild, efficient Friedel-Crafts acylations from carboxylic acids using cyanuric chloride and AlCl3.

Guidelines for reporting the use of gel electrophoresis in proteomics.

Synthesis and biological evaluation of (-)-dictyostatin and stereoisomers.

Improved synthesis of 6-epi-dictyostatin and antitumor efficacy in mice bearing MDA-MB231 human breast cancer xenografts.

APC is essential for targeting phosphorylated beta-catenin to the SCFbeta-TrCP ubiquitin ligase.

Microtubule binding and disruption and induction of premature senescence by disorazole C(1).

Select pyrimidinones inhibit the propagation of the malarial parasite, Plasmodium falciparum.

Polyhydroxylalkyleneamines: a class of hydrophilic cationic polymer-based gene transfer agents.

Biphenyl C-cyclopropylalkylamides: New scaffolds for targeting estrogen receptor beta.

Design and synthesis of a library of tetracyclic hydroazulenoisoindoles.

Zebrafish chemical screening reveals an inhibitor of Dusp6 that expands cardiac cell lineages.

Evaluation of biosensor surfaces for the detection of microtubule perturbation.

Meayamycin inhibits pre-messenger RNA splicing and exhibits picomolar activity against multidrug-resistant cells.

High-content analysis of cancer-cell-specific apoptosis and inhibition of in vivo angiogenesis by synthetic (-)-pironetin and analogs.

Human liver microsomal metabolism of (+)-discodermolide.

Identification of ATP citrate lyase as a positive regulator of glycolytic function in glioblastomas.

Chemical library screens targeting an HIV-1 accessory factor/host cell kinase complex identify novel antiretroviral compounds.

A functionalizable polyester with free hydroxyl groups and tunable physiochemical and biological properties.

Azide-tetrazole equilibrium of C-6 azidopurine nucleosides and their ligation reactions with alkynes.

Inhibition of histone deacetylase expands the renal progenitor cell population.

Streamlined syntheses of (-)-dictyostatin, 16-desmethyl-25,26-dihydrodictyostatin, and 6-epi-16-desmethyl-25,26-dihydrodictyostatin.

Regulation of the autophagy protein LC3 by phosphorylation.

Characterization and detection of cellular and proteomic alterations in stable stathmin-overexpressing, taxol-resistant BT549 breast cancer cells using offgel IEF/PAGE difference gel electrophoresis.

A simplified synthesis of novel dictyostatin analogues with in vitro activity against epothilone B-resistant cells and antiangiogenic activity in zebrafish embryos.

Total synthesis and biological evaluation of pederin, psymberin, and highly potent analogs.

Characterization of Inhibitors of Glucocorticoid Receptor Nuclear Translocation: A Model of Cytoplasmic Dynein-Mediated Cargo Transport.

Efficient syntheses of 25,26-dihydrodictyostatin and 25,26-dihydro-6-epi-dictyostatin, two potent new microtubule-stabilizing agents.

Theory and applications of surface plasmon resonance, resonant mirror, resonant waveguide grating, and dual polarization interferometry biosensors.

Synthesis and Biological Evaluation of Neopeltolide and Analogs.