Natalie L. Trevaskis

Profiling the Role of Deacylation-Reacylation in the Lymphatic Transport of a Triglyceride-Mimetic Prodrug.

Bile increases intestinal lymphatic drug transport in the fasted rat.

Tissue uptake of DDT is independent of chylomicron metabolism.

The lymph lipid precursor pool is a key determinant of intestinal lymphatic drug transport.

An examination of the interplay between enterocyte-based metabolism and lymphatic drug transport in the rat.

An acute and coincident increase in FABP expression and lymphatic lipid and drug transport occurs during intestinal infusion of lipid-based drug formulations to rats.

Lipids and lipid-based formulations: optimizing the oral delivery of lipophilic drugs.

Lipid-based delivery systems and intestinal lymphatic drug transport: a mechanistic update.

Intestinal lymphatic transport enhances the post-prandial oral bioavailability of a novel cannabinoid receptor agonist via avoidance of first-pass metabolism.

The role of the intestinal lymphatics in the absorption of two highly lipophilic cholesterol ester transfer protein inhibitors (CP524,515 and CP532,623).

The mechanism of lymphatic access of two cholesteryl ester transfer protein inhibitors (CP524,515 and CP532,623) and evaluation of their impact on lymph lipoprotein profiles.

Targeted drug delivery to lymphocytes: a route to site-specific immunomodulation?

Fatty acid binding proteins: potential chaperones of cytosolic drug transport in the enterocyte?

Acute hypertriglyceridemia promotes intestinal lymphatic lipid and drug transport: a positive feedback mechanism in lipid and drug absorption.

Correction to "targeted drug delivery to lymphocytes: a route to site-specific immunomodulation?".

Intravenous dosing conditions may affect systemic clearance for highly lipophilic drugs: implications for lymphatic transport and absolute bioavailability studies.

Strategies to address low drug solubility in discovery and development.

A mouse model to evaluate the impact of species, sex, and lipid load on lymphatic drug transport.

Intestinal bile secretion promotes drug absorption from lipid colloidal phases via induction of supersaturation.

The impact of lymphatic transport on the systemic disposition of lipophilic drugs.

The potential for drug supersaturation during intestinal processing of lipid-based formulations may be enhanced for basic drugs.

Lipid absorption triggers drug supersaturation at the intestinal unstirred water layer and promotes drug absorption from mixed micelles.

Lipid-based formulations and drug supersaturation: harnessing the unique benefits of the lipid digestion/absorption pathway.

Recent advances in lipid-based formulation technology.

Targeted delivery of a model immunomodulator to the lymphatic system: comparison of alkyl ester versus triglyceride mimetic lipid prodrug strategies.

In vitro-in vivo evaluation of lipid based formulations of the CETP inhibitors CP-529,414 (torcetrapib) and CP-532,623.

Methotrexate-conjugated PEGylated dendrimers show differential patterns of deposition and activity in tumour-burdened lymph nodes after intravenous and subcutaneous administration in rats.