Shaun R. Coughlin

Genetic evidence that protease-activated receptors mediate factor Xa signaling in endothelial cells.

Protection against thrombosis in mice lacking PAR3.

Overview of the Alliance for Cellular Signaling.

PARticipation in inflammation.

The Rho guanine nucleotide exchange factor Lsc homo-oligomerizes and is negatively regulated through domains in its carboxyl terminus that are absent in novel splenic isoforms.

Protease-activated receptors 1 and 4 mediate thrombin signaling in endothelial cells.

Combined deficiency of protease-activated receptor-4 and fibrinogen recapitulates the hemostatic defect but not the embryonic lethality of prothrombin deficiency.

Regulated shedding of PAR1 N-terminal exodomain from endothelial cells.

Platelets, protease-activated receptors, and fibrinogen in hematogenous metastasis.

PAR1 cleavage and signaling in response to activated protein C and thrombin.

Essential role for Galpha13 in endothelial cells during embryonic development.

Protease-activated receptor-2 activation induces acute lung inflammation by neuropeptide-dependent mechanisms.

Roles of protease-activated receptors in a mouse model of endotoxemia.

Par4 is required for platelet thrombus propagation but not fibrin generation in a mouse model of thrombosis.

Promotion of lymphocyte egress into blood and lymph by distinct sources of sphingosine-1-phosphate.

Fetal gene defects precipitate platelet-mediated pregnancy failure in factor V Leiden mothers.

Protease-activated receptor 2, dipeptidyl peptidase I, and proteases mediate Clostridium difficile toxin A enteritis.

Probing cell type-specific functions of Gi in vivo identifies GPCR regulators of insulin secretion.

A critical role for extracellular protein disulfide isomerase during thrombus formation in mice.

Maternal Par4 and platelets contribute to defective placenta formation in mouse embryos lacking thrombomodulin.

Anatomical profiling of G protein-coupled receptor expression.

Identification of a transient subpial neurogenic zone in the developing dentate gyrus and its regulation by Cxcl12 and reelin signaling.

Sphingosine-1-phosphate in the plasma compartment regulates basal and inflammation-induced vascular leak in mice.

Lymphatic endothelial cell sphingosine kinase activity is required for lymphocyte egress and lymphatic patterning.

Local protease signaling contributes to neural tube closure in the mouse embryo.

Identifying patients at high risk of a cardiovascular event in the near future: current status and future directions: report of a national heart, lung, and blood institute working group.

Roles and interactions among protease-activated receptors and P2ry12 in hemostasis and thrombosis.

PAR2 absence completely rescues inflammation and ichthyosis caused by altered CAP1/Prss8 expression in mouse skin.

The sphingosine 1-phosphate receptor S1P₂ maintains the homeostasis of germinal center B cells and promotes niche confinement.

Carcinoma mucins trigger reciprocal activation of platelets and neutrophils in a murine model of Trousseau syndrome.

Wnt/β-catenin signaling is differentially regulated by Gα proteins and contributes to fibrous dysplasia.

TMEM16F forms a Ca2+-activated cation channel required for lipid scrambling in platelets during blood coagulation.

PAR1 contributes to influenza A virus pathogenicity in mice.

High-resolution crystal structure of human protease-activated receptor 1.

IL-7 production in murine lymphatic endothelial cells and induction in the setting of peripheral lymphopenia.

Podoplanin maintains high endothelial venule integrity by interacting with platelet CLEC-2.

Redundancy and interaction of thrombin- and collagen-mediated platelet activation in tail bleeding and carotid thrombosis in mice.

Gαi/o-coupled receptor signaling restricts pancreatic β-cell expansion.