Cardiovascular Research Institute
Shaun R. Coughlin has not added Biography.
If you are Shaun R. Coughlin and would like to personalize this page please email our Author Liaison for assistance.
Genetic evidence that protease-activated receptors mediate factor Xa signaling in endothelial cells.
The Journal of biological chemistry May, 2002 | Pubmed ID: 11850418
Protection against thrombosis in mice lacking PAR3.
Blood Nov, 2002 | Pubmed ID: 12384423
Overview of the Alliance for Cellular Signaling.
Nature Dec, 2002 | Pubmed ID: 12478301
PARticipation in inflammation.
The Journal of clinical investigation Jan, 2003 | Pubmed ID: 12511583
The Rho guanine nucleotide exchange factor Lsc homo-oligomerizes and is negatively regulated through domains in its carboxyl terminus that are absent in novel splenic isoforms.
The Journal of biological chemistry Aug, 2003 | Pubmed ID: 12773540
Protease-activated receptors 1 and 4 mediate thrombin signaling in endothelial cells.
Blood Nov, 2003 | Pubmed ID: 12869501
Combined deficiency of protease-activated receptor-4 and fibrinogen recapitulates the hemostatic defect but not the embryonic lethality of prothrombin deficiency.
Blood Jan, 2004 | Pubmed ID: 14504091
Regulated shedding of PAR1 N-terminal exodomain from endothelial cells.
The Journal of biological chemistry Apr, 2004 | Pubmed ID: 14982936
Platelets, protease-activated receptors, and fibrinogen in hematogenous metastasis.
Blood Jul, 2004 | Pubmed ID: 15031212
PAR1 cleavage and signaling in response to activated protein C and thrombin.
The Journal of biological chemistry Apr, 2005 | Pubmed ID: 15665002
Essential role for Galpha13 in endothelial cells during embryonic development.
Proceedings of the National Academy of Sciences of the United States of America Jun, 2005 | Pubmed ID: 15919816
Protease-activated receptor-2 activation induces acute lung inflammation by neuropeptide-dependent mechanisms.
Journal of immunology (Baltimore, Md. : 1950) Aug, 2005 | Pubmed ID: 16081834
Roles of protease-activated receptors in a mouse model of endotoxemia.
Blood May, 2006 | Pubmed ID: 16434493
Par4 is required for platelet thrombus propagation but not fibrin generation in a mouse model of thrombosis.
Proceedings of the National Academy of Sciences of the United States of America Jan, 2007 | Pubmed ID: 17190826
Promotion of lymphocyte egress into blood and lymph by distinct sources of sphingosine-1-phosphate.
Science (New York, N.Y.) Apr, 2007 | Pubmed ID: 17363629
Fetal gene defects precipitate platelet-mediated pregnancy failure in factor V Leiden mothers.
The Journal of experimental medicine May, 2007 | Pubmed ID: 17438064
Protease-activated receptor 2, dipeptidyl peptidase I, and proteases mediate Clostridium difficile toxin A enteritis.
Gastroenterology Jun, 2007 | Pubmed ID: 17570216
Probing cell type-specific functions of Gi in vivo identifies GPCR regulators of insulin secretion.
The Journal of clinical investigation Dec, 2007 | Pubmed ID: 17992256
A critical role for extracellular protein disulfide isomerase during thrombus formation in mice.
The Journal of clinical investigation Mar, 2008 | Pubmed ID: 18292814
Maternal Par4 and platelets contribute to defective placenta formation in mouse embryos lacking thrombomodulin.
Blood Aug, 2008 | Pubmed ID: 18490515
Anatomical profiling of G protein-coupled receptor expression.
Cell Oct, 2008 | Pubmed ID: 18984166
Identification of a transient subpial neurogenic zone in the developing dentate gyrus and its regulation by Cxcl12 and reelin signaling.
Development (Cambridge, England) Jan, 2009 | Pubmed ID: 19103804
Sphingosine-1-phosphate in the plasma compartment regulates basal and inflammation-induced vascular leak in mice.
The Journal of clinical investigation Jul, 2009 | Pubmed ID: 19603543
Lymphatic endothelial cell sphingosine kinase activity is required for lymphocyte egress and lymphatic patterning.
The Journal of experimental medicine Jan, 2010 | Pubmed ID: 20026661
Local protease signaling contributes to neural tube closure in the mouse embryo.
Developmental cell Jan, 2010 | Pubmed ID: 20152175
Identifying patients at high risk of a cardiovascular event in the near future: current status and future directions: report of a national heart, lung, and blood institute working group.
Circulation Mar, 2010 | Pubmed ID: 20351302
Roles and interactions among protease-activated receptors and P2ry12 in hemostasis and thrombosis.
Proceedings of the National Academy of Sciences of the United States of America Oct, 2010 | Pubmed ID: 20930120
PAR2 absence completely rescues inflammation and ichthyosis caused by altered CAP1/Prss8 expression in mouse skin.
Nature communications Jan, 2011 | Pubmed ID: 21245842
The sphingosine 1-phosphate receptor S1P₂ maintains the homeostasis of germinal center B cells and promotes niche confinement.
Nature immunology Jul, 2011 | Pubmed ID: 21642988
Carcinoma mucins trigger reciprocal activation of platelets and neutrophils in a murine model of Trousseau syndrome.
Blood Oct, 2011 | Pubmed ID: 21860019
Wnt/β-catenin signaling is differentially regulated by Gα proteins and contributes to fibrous dysplasia.
Proceedings of the National Academy of Sciences of the United States of America Dec, 2011 | Pubmed ID: 22106277
TMEM16F forms a Ca2+-activated cation channel required for lipid scrambling in platelets during blood coagulation.
Cell Sep, 2012 | Pubmed ID: 23021219
PAR1 contributes to influenza A virus pathogenicity in mice.
The Journal of clinical investigation Jan, 2013 | Pubmed ID: 23202729
High-resolution crystal structure of human protease-activated receptor 1.
Nature Dec, 2012 | Pubmed ID: 23222541
IL-7 production in murine lymphatic endothelial cells and induction in the setting of peripheral lymphopenia.
International immunology Aug, 2013 | Pubmed ID: 23657000
Podoplanin maintains high endothelial venule integrity by interacting with platelet CLEC-2.
Nature Oct, 2013 | Pubmed ID: 23995678
Redundancy and interaction of thrombin- and collagen-mediated platelet activation in tail bleeding and carotid thrombosis in mice.
Arteriosclerosis, thrombosis, and vascular biology Dec, 2014 | Pubmed ID: 25278288
Gαi/o-coupled receptor signaling restricts pancreatic β-cell expansion.
Proceedings of the National Academy of Sciences of the United States of America Mar, 2015 | Pubmed ID: 25695968
JoVE 소개
Copyright © 2024 MyJoVE Corporation. 판권 소유