Chromatin Structure and Mobile DNA
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Role of Yersinia murine toxin in survival of Yersinia pestis in the midgut of the flea vector.
Science (New York, N.Y.) Apr, 2002 | Pubmed ID: 11976454
New class of HIV integrase inhibitors that block viral replication in cell culture.
Current biology : CB Jul, 2002 | Pubmed ID: 12176326
In search of authentic inhibitors of HIV-1 integration.
Antiviral chemistry & chemotherapy Jan, 2002 | Pubmed ID: 12180645
HIV-1 integrase forms stable tetramers and associates with LEDGF/p75 protein in human cells.
The Journal of biological chemistry Jan, 2003 | Pubmed ID: 12407101
env chimeric virus technology for evaluating human immunodeficiency virus susceptibility to entry inhibitors.
Antimicrobial agents and chemotherapy Dec, 2002 | Pubmed ID: 12435701
pH6 antigen of Yersinia pestis interacts with plasma lipoproteins and cell membranes.
Journal of lipid research Feb, 2003 | Pubmed ID: 12576514
LEDGF/p75 is essential for nuclear and chromosomal targeting of HIV-1 integrase in human cells.
The Journal of biological chemistry Aug, 2003 | Pubmed ID: 12796494
Expression of HIV-1 integrase in CEM cells inhibits HIV-1 replication.
The journal of gene medicine Mar, 2004 | Pubmed ID: 15026988
Identification and characterization of a functional nuclear localization signal in the HIV-1 integrase interactor LEDGF/p75.
The Journal of biological chemistry Aug, 2004 | Pubmed ID: 15163664
Identification of an evolutionarily conserved domain in human lens epithelium-derived growth factor/transcriptional co-activator p75 (LEDGF/p75) that binds HIV-1 integrase.
The Journal of biological chemistry Nov, 2004 | Pubmed ID: 15371438
Class II integrase mutants with changes in putative nuclear localization signals are primarily blocked at a postnuclear entry step of human immunodeficiency virus type 1 replication.
Journal of virology Dec, 2004 | Pubmed ID: 15542626
Solution structure of the HIV-1 integrase-binding domain in LEDGF/p75.
Nature structural & molecular biology Jun, 2005 | Pubmed ID: 15895093
Mutations in both env and gag genes are required for HIV-1 resistance to the polysulfonic dendrimer SPL2923, as corroborated by chimeric virus technology.
Antiviral chemistry & chemotherapy , 2005 | Pubmed ID: 16130523
Lys-34, dispensable for integrase catalysis, is required for preintegration complex function and human immunodeficiency virus type 1 replication.
Journal of virology Oct, 2005 | Pubmed ID: 16160186
Structural basis for the recognition between HIV-1 integrase and transcriptional coactivator p75.
Proceedings of the National Academy of Sciences of the United States of America Nov, 2005 | Pubmed ID: 16260736
A tripartite DNA-binding element, comprised of the nuclear localization signal and two AT-hook motifs, mediates the association of LEDGF/p75 with chromatin in vivo.
Nucleic acids research , 2006 | Pubmed ID: 16549878
Transcriptional co-activator p75 binds and tethers the Myc-interacting protein JPO2 to chromatin.
Journal of cell science Jun, 2006 | Pubmed ID: 16735438
Structure-based mutagenesis of the integrase-LEDGF/p75 interface uncouples a strict correlation between in vitro protein binding and HIV-1 fitness.
Virology Jan, 2007 | Pubmed ID: 16959283
LEDGF/p75 interacts with divergent lentiviral integrases and modulates their enzymatic activity in vitro.
Nucleic acids research , 2007 | Pubmed ID: 17158150
LEDGF/p75 functions downstream from preintegration complex formation to effect gene-specific HIV-1 integration.
Genes & development Jul, 2007 | Pubmed ID: 17639082
The lentiviral integrase binding protein LEDGF/p75 and HIV-1 replication.
PLoS pathogens Mar, 2008 | Pubmed ID: 18369482
Functional and structural characterization of the integrase from the prototype foamy virus.
Nucleic acids research Jan, 2009 | Pubmed ID: 19036793
A novel co-crystal structure affords the design of gain-of-function lentiviral integrase mutants in the presence of modified PSIP1/LEDGF/p75.
PLoS pathogens Jan, 2009 | Pubmed ID: 19132083
HIV-1 exploits importin 7 to maximize nuclear import of its DNA genome.
Retrovirology , 2009 | Pubmed ID: 19193229
The SET complex acts as a barrier to autointegration of HIV-1.
PLoS pathogens Mar, 2009 | Pubmed ID: 19266025
Structural basis for functional tetramerization of lentiviral integrase.
PLoS pathogens Jul, 2009 | Pubmed ID: 19609359
Application of general formulas for the correction of a lattice-translocation defect in crystals of a lentiviral integrase in complex with LEDGF.
Acta crystallographica. Section D, Biological crystallography Sep, 2009 | Pubmed ID: 19690374
Transcriptional co-activator LEDGF interacts with Cdc7-activator of S-phase kinase (ASK) and stimulates its enzymatic activity.
The Journal of biological chemistry Jan, 2010 | Pubmed ID: 19864417
Retroviral intasome assembly and inhibition of DNA strand transfer.
Nature Mar, 2010 | Pubmed ID: 20118915
Integrase illuminated.
EMBO reports May, 2010 | Pubmed ID: 20428106
Structure-based modeling of the functional HIV-1 intasome and its inhibition.
Proceedings of the National Academy of Sciences of the United States of America Sep, 2010 | Pubmed ID: 20733078
Molecular mechanisms of retroviral integrase inhibition and the evolution of viral resistance.
Proceedings of the National Academy of Sciences of the United States of America Nov, 2010 | Pubmed ID: 21030679
The mechanism of retroviral integration from X-ray structures of its key intermediates.
Nature Nov, 2010 | Pubmed ID: 21068843
Structural biology of retroviral DNA integration.
Virology Mar, 2011 | Pubmed ID: 21216426
Structural insights into the retroviral DNA integration apparatus.
Current opinion in structural biology Apr, 2011 | Pubmed ID: 21277766
Structural and functional analyses of the second-generation integrase strand transfer inhibitor dolutegravir (S/GSK1349572).
Molecular pharmacology Oct, 2011 | Pubmed ID: 21719464
The Interaction Between Lentiviral Integrase and LEDGF: Structural and Functional Insights.
Viruses Dec, 2009 | Pubmed ID: 21994569
The structural biology of HIV-1: mechanistic and therapeutic insights.
Nature reviews. Microbiology Apr, 2012 | Pubmed ID: 22421880
3'-processing and strand transfer catalysed by retroviral integrase in crystallo.
The EMBO journal Jun, 2012 | Pubmed ID: 22580823
Solution conformations of prototype foamy virus integrase and its stable synaptic complex with U5 viral DNA.
Structure (London, England : 1993) Nov, 2012 | Pubmed ID: 23000384
HRP2 determines the efficiency and specificity of HIV-1 integration in LEDGF/p75 knockout cells but does not contribute to the antiviral activity of a potent LEDGF/p75-binding site integrase inhibitor.
Nucleic acids research Dec, 2012 | Pubmed ID: 23042676
Crystal structure of human CDC7 kinase in complex with its activator DBF4.
Nature structural & molecular biology Nov, 2012 | Pubmed ID: 23064647
Activities, crystal structures, and molecular dynamics of dihydro-1H-isoindole derivatives, inhibitors of HIV-1 integrase.
ACS chemical biology Jan, 2013 | Pubmed ID: 23075516
Centralspindlin links the mitotic spindle to the plasma membrane during cytokinesis.
Nature Dec, 2012 | Pubmed ID: 23235882
Bromo- and extraterminal domain chromatin regulators serve as cofactors for murine leukemia virus integration.
Journal of virology Dec, 2013 | Pubmed ID: 24049186
Structural basis for nuclear import of splicing factors by human Transportin 3.
Proceedings of the National Academy of Sciences of the United States of America Feb, 2014 | Pubmed ID: 24449914
Integrase residues that determine nucleotide preferences at sites of HIV-1 integration: implications for the mechanism of target DNA binding.
Nucleic acids research Apr, 2014 | Pubmed ID: 24520116
Efficient Transduction of LEDGF/p75 Mutant Cells by Gain-of-Function HIV-1 Integrase Mutant Viruses.
Molecular therapy. Methods & clinical development Jan, 2014 | Pubmed ID: 25383358
Retroviral Integrase Structure and DNA Recombination Mechanism.
Microbiology spectrum , 2014 | Pubmed ID: 25705574
Key determinants of target DNA recognition by retroviral intasomes.
Retrovirology , 2015 | Pubmed ID: 25924943
Structural basis for retroviral integration into nucleosomes.
Nature Jul, 2015 | Pubmed ID: 26061770
Retroviral Integrase Structure and DNA Recombination Mechanism.
Microbiology spectrum Dec, 2014 | Pubmed ID: 26104441
HIV-1 Integrase Strand Transfer Inhibitors with Reduced Susceptibility to Drug Resistant Mutant Integrases.
ACS chemical biology Feb, 2016 | Pubmed ID: 26808478
Cryo-EM reveals a novel octameric integrase structure for betaretroviral intasome function.
Nature Feb, 2016 | Pubmed ID: 26887496