Peter Cherepanov

Role of Yersinia murine toxin in survival of Yersinia pestis in the midgut of the flea vector.

New class of HIV integrase inhibitors that block viral replication in cell culture.

In search of authentic inhibitors of HIV-1 integration.

HIV-1 integrase forms stable tetramers and associates with LEDGF/p75 protein in human cells.

env chimeric virus technology for evaluating human immunodeficiency virus susceptibility to entry inhibitors.

pH6 antigen of Yersinia pestis interacts with plasma lipoproteins and cell membranes.

LEDGF/p75 is essential for nuclear and chromosomal targeting of HIV-1 integrase in human cells.

Expression of HIV-1 integrase in CEM cells inhibits HIV-1 replication.

Identification and characterization of a functional nuclear localization signal in the HIV-1 integrase interactor LEDGF/p75.

Identification of an evolutionarily conserved domain in human lens epithelium-derived growth factor/transcriptional co-activator p75 (LEDGF/p75) that binds HIV-1 integrase.

Class II integrase mutants with changes in putative nuclear localization signals are primarily blocked at a postnuclear entry step of human immunodeficiency virus type 1 replication.

Solution structure of the HIV-1 integrase-binding domain in LEDGF/p75.

Mutations in both env and gag genes are required for HIV-1 resistance to the polysulfonic dendrimer SPL2923, as corroborated by chimeric virus technology.

Lys-34, dispensable for integrase catalysis, is required for preintegration complex function and human immunodeficiency virus type 1 replication.

Structural basis for the recognition between HIV-1 integrase and transcriptional coactivator p75.

A tripartite DNA-binding element, comprised of the nuclear localization signal and two AT-hook motifs, mediates the association of LEDGF/p75 with chromatin in vivo.

Transcriptional co-activator p75 binds and tethers the Myc-interacting protein JPO2 to chromatin.

Structure-based mutagenesis of the integrase-LEDGF/p75 interface uncouples a strict correlation between in vitro protein binding and HIV-1 fitness.

LEDGF/p75 interacts with divergent lentiviral integrases and modulates their enzymatic activity in vitro.

LEDGF/p75 functions downstream from preintegration complex formation to effect gene-specific HIV-1 integration.

The lentiviral integrase binding protein LEDGF/p75 and HIV-1 replication.

Functional and structural characterization of the integrase from the prototype foamy virus.

A novel co-crystal structure affords the design of gain-of-function lentiviral integrase mutants in the presence of modified PSIP1/LEDGF/p75.

HIV-1 exploits importin 7 to maximize nuclear import of its DNA genome.

The SET complex acts as a barrier to autointegration of HIV-1.

Structural basis for functional tetramerization of lentiviral integrase.

Application of general formulas for the correction of a lattice-translocation defect in crystals of a lentiviral integrase in complex with LEDGF.

Transcriptional co-activator LEDGF interacts with Cdc7-activator of S-phase kinase (ASK) and stimulates its enzymatic activity.

Retroviral intasome assembly and inhibition of DNA strand transfer.

Integrase illuminated.

Structure-based modeling of the functional HIV-1 intasome and its inhibition.

Molecular mechanisms of retroviral integrase inhibition and the evolution of viral resistance.

The mechanism of retroviral integration from X-ray structures of its key intermediates.

Structural biology of retroviral DNA integration.

Structural insights into the retroviral DNA integration apparatus.

Structural and functional analyses of the second-generation integrase strand transfer inhibitor dolutegravir (S/GSK1349572).

The Interaction Between Lentiviral Integrase and LEDGF: Structural and Functional Insights.

The structural biology of HIV-1: mechanistic and therapeutic insights.

3'-processing and strand transfer catalysed by retroviral integrase in crystallo.

Solution conformations of prototype foamy virus integrase and its stable synaptic complex with U5 viral DNA.

HRP2 determines the efficiency and specificity of HIV-1 integration in LEDGF/p75 knockout cells but does not contribute to the antiviral activity of a potent LEDGF/p75-binding site integrase inhibitor.

Crystal structure of human CDC7 kinase in complex with its activator DBF4.

Activities, crystal structures, and molecular dynamics of dihydro-1H-isoindole derivatives, inhibitors of HIV-1 integrase.

Centralspindlin links the mitotic spindle to the plasma membrane during cytokinesis.

Bromo- and extraterminal domain chromatin regulators serve as cofactors for murine leukemia virus integration.

Structural basis for nuclear import of splicing factors by human Transportin 3.

Integrase residues that determine nucleotide preferences at sites of HIV-1 integration: implications for the mechanism of target DNA binding.

Efficient Transduction of LEDGF/p75 Mutant Cells by Gain-of-Function HIV-1 Integrase Mutant Viruses.

Retroviral Integrase Structure and DNA Recombination Mechanism.

Key determinants of target DNA recognition by retroviral intasomes.

Structural basis for retroviral integration into nucleosomes.

Retroviral Integrase Structure and DNA Recombination Mechanism.

HIV-1 Integrase Strand Transfer Inhibitors with Reduced Susceptibility to Drug Resistant Mutant Integrases.

Cryo-EM reveals a novel octameric integrase structure for betaretroviral intasome function.