Fumitaka Kikkawa

Paclitaxel-2'-Ethylcarbonate prodrug can circumvent P-glycoprotein-mediated cellular efflux to increase drug cytotoxicity.

Localization of angiotensin II, the AT1 receptor, angiotensin-converting enzyme, aminopeptidase A, adipocyte-derived leucine aminopeptidase, and vascular endothelial growth factor in the human ovary throughout the menstrual cycle.

[Trophoblastic disease].

Long-term follow-up and prognostic factor analysis in clear cell adenocarcinoma of the ovary.

Endometrioid adenocarcinoma arising from endometriosis during 2 years of estrogen replacement therapy after total hysterectomy and bilateral salpingo-oophorectomy.

Neutral endopeptidase expressed by decidualized stromal cells suppresses akt phosphorylation and deoxyribonucleic acid synthesis induced by endothelin-1 in human endometrium.

Intercellular trafficking and cytotoxicity of recombinant HSV-1 thymidine kinase fused with HSV-2 US11 RXP repeat peptide.

Impaired insulin-regulated membrane aminopeptidase translocation to the plasma membrane in adipocytes of Otsuka Long Evans Tokushima Fatty rats.

Preferable correlation to blastocyst development and pregnancy rates with a new embryo grading system specific for day 3 embryos.

Involvement of DPPIV/CD26 in epithelial morphology and suppressed invasive ability in ovarian carcinoma cells.

P-LAP/IRAP-induced cell proliferation and glucose uptake in endometrial carcinoma cells via insulin receptor signaling.

Involvement of aminopeptidase N in enhanced chemosensitivity to paclitaxel in ovarian carcinoma in vitro and in vivo.

Successful treatment of a heterotopic cervical pregnancy and twin gestation by sonographically guided instillation of hyperosmolar glucose.

Essential role of placental leucine aminopeptidase in gynecologic malignancy.

Possible involvement of TWIST in enhanced peritoneal metastasis of epithelial ovarian carcinoma.

The MRI findings of the right-sided fetal lung can be used to predict postnatal mortality and the requirement for extracorporeal membrane oxygenation in isolated left-sided congenital diaphragmatic hernia.

Uterine smooth muscle cells increase invasive ability of endometrial carcinoma cells through tumor-stromal interaction.

Successful management of a massive hemorrhage due to rupture of cystic cervical endometriosis by a loop electrosurgical excision procedure.

Chemoresistance to paclitaxel induces epithelial-mesenchymal transition and enhances metastatic potential for epithelial ovarian carcinoma cells.

Establishment of a new cell line of endometrioid carcinoma of the ovary and its chemosensitivity.

Inhibition of APN/CD13 leads to suppressed progressive potential in ovarian carcinoma cells.

Genetically identified complete hydatidiform mole coexisting with a live twin fetus: comparison with conventional diagnosis.

Twist expression predicts poor clinical outcome of patients with clear cell carcinoma of the ovary.

Distribution of endothelin-converting enzyme-1 and neutral endopeptidase in human endometrium.

Placenta previa increta/percreta in Japan: a retrospective study of ultrasound findings, management and clinical course.

Possible involvement of SDF-1alpha/CXCR4-DPPIV axis in TGF-beta1-induced enhancement of migratory potential in human peritoneal mesothelial cells.

Reversibility of the adverse effects of 1-bromopropane exposure in rats.

Involvement of SDF-1alpha/CXCR4 axis in the enhanced peritoneal metastasis of epithelial ovarian carcinoma.

The plausibility of Helicobacter pylori-related infertility in Japan.

Irradiation-induced epithelial-mesenchymal transition (EMT) related to invasive potential in endometrial carcinoma cells.

Oral progestogen versus intramuscular progesterone for luteal support after assisted reproductive technology treatment: a prospective randomized study.

PTEN and Akt expression during growth of human ovarian follicles.

Angiotensin II mimics the hypoxic effect on regulating trophoblast proliferation and differentiation in human placental explant cultures.

Gene directed enzyme prodrug therapy for ovarian cancer: could GDEPT become a promising treatment against ovarian cancer?

Taxol resistance among the different histological subtypes of ovarian cancer may be associated with the expression of class III beta-tubulin.

Identification of genes differentially expressed in mouse fetuses from streptozotocin-induced diabetic pregnancy by cDNA subtraction.

Aminopeptidase N (APN)/CD13 inhibitor, Ubenimex, enhances radiation sensitivity in human cervical cancer.

Microarray analysis of transcriptional responses to infection by herpes simplex virus types 1 and 2 and their US3-deficient mutants.

Inverse correlation between tumoral indoleamine 2,3-dioxygenase expression and tumor-infiltrating lymphocytes in endometrial cancer: its association with disease progression and survival.

Reduced risk of endometrial cancer from alcohol drinking in Japanese.

Non-engineered, naturally oncolytic herpes simplex virus HSV1 HF-10: applications for cancer gene therapy.

Is there any possibility of fertility-sparing surgery in patients with clear-cell carcinoma of the ovary?

Establishment and characterization of an ovarian yolk sac tumor cell line reveals possible involvement of Nkx2.5 in tumor development.

Feasibility and effectiveness of postoperative adjuvant concurrent chemoradiation therapy in Japanese patients with high-risk early-stage cancer of the uterine cervix.

Long-term outcome and prognostic factors for yolk sac tumor of the ovary.

N-acetylglucosaminyltransferase V regulates extravillous trophoblast invasion through glycosylation of alpha5beta1 integrin.

Overexpression of indoleamine 2,3-dioxygenase in human endometrial carcinoma cells induces rapid tumor growth in a mouse xenograft model.

Association between CYP19A1 polymorphisms and sex hormones in postmenopausal Japanese women.

Scar endometriosis after a laparotomy for uterine perforation as a complication of dilatation and curettage.

IGF1-induced AKT phosphorylation and cell proliferation are suppressed with the increase in PTEN during luteinization in human granulosa cells.

Insulin attenuates the insulin-like growth factor-I (IGF-I)-Akt pathway, not IGF-I-extracellularly regulated kinase pathway, in luteinized granulosa cells with an increase in PTEN.

Activator protein-2 impairs the invasion of a human extravillous trophoblast cell line.

Human papillomavirus type 16 oncoprotein E7 suppresses cadherin-mediated cell adhesion via ERK and AP-1 signaling.

Enhanced cytotoxicity with a novel system combining the paclitaxel-2'-ethylcarbonate prodrug and an HSV amplicon with an attenuated replication-competent virus, HF10 as a helper virus.

Tocilizumab inhibits interleukin-6-mediated matrix metalloproteinase-2 and -9 secretions from human amnion cells in preterm premature rupture of membranes.

Expression of Ret finger protein correlates with outcomes in endometrial cancer.

Role of the immunosuppressive enzyme indoleamine 2,3-dioxygenase in the progression of ovarian carcinoma.

High expression of N-acetylglucosaminyltransferase V in mucinous tumors of the ovary.

Gene silencing of glypican-3 in clear cell carcinoma of the ovary renders it more sensitive to the apoptotic agent paclitaxel in vitro and in vivo.

Histamine stimulates interleukin-6 production through histamine H1 receptors in human amnion cells.

The expression of dipeptidyl peptidase IV (DPPIV/CD26) is associated with enhanced chemosensitivity to paclitaxel in epithelial ovarian carcinoma cells.

Thyroid transcription factor 1 expression in ovarian carcinomas is an independent prognostic factor.

Evaluation of the safety of time-lapse observations for human embryos.

Intra-amniotic infection increases amniotic lamellar body count before 34 weeks of gestation.

Assessment of the predictive value of follicular fluid insulin, leptin and adiponectin in assisted reproductive cycles.

Three-dimensional CT angiography is useful for diagnosis of postabortion uterine hemorrhage: 3 case reports and review of the literature.

Indoleamine 2,3-dioxygenase expression predicts impaired survival of invasive cervical cancer patients treated with radical hysterectomy.

HLA-A alleles and the risk of cervical squamous cell carcinoma in Japanese women.

Serum anti-Müllerian hormone level is a useful marker for evaluating the impact of laparoscopic cystectomy on ovarian reserve.

Growth-suppressing function of glypican-3 (GPC3) via insulin like growth factor II (IGF-II) signaling pathway in ovarian clear cell carcinoma cells.

Identification and characterization of cancer stem cells in ovarian yolk sac tumors.

Glypican-3 expression predicts poor clinical outcome of patients with early-stage clear cell carcinoma of the ovary.

Fertility-sparing operation for recurrence of uterine cervical perivascular epithelioid cell tumor.

Establishment of cisplatin-resistant ovarian yolk sac tumor cells and investigation of the mechanism of cisplatin resistance using this cell line.

Successful fertility management of a patient with factor V deficiency: planned transfusion of fresh frozen plasma under infertility treatment.

The post-operative decline in serum anti-Mullerian hormone correlates with the bilaterality and severity of endometriosis.

Amniotic lamellar body counts can predict the occurrence of respiratory distress syndrome as well as transient tachypnea of the newborn (TTN).

Spectrin αII and βII tetramers contribute to platinum anticancer drug resistance in ovarian serous adenocarcinoma.

Role of the renin-angiotensin system in gynecologic cancers.

Comparison between serous and non-serous ovarian cancer as a prognostic factor in advanced epithelial ovarian carcinoma after primary debulking surgery.

[New staging system for endometrial neoplasms].

Mismatched human leukocyte antigen class II-restricted CD8⁺ cytotoxic T cells may mediate selective graft-versus-leukemia effects following allogeneic hematopoietic cell transplantation.

Maternal mental disorders and pregnancy outcomes: a clinical study in a Japanese population.

Fertility-sparing surgery in young women with mucinous adenocarcinoma of the ovary.

Glypican-3 could be an effective target for immunotherapy combined with chemotherapy against ovarian clear cell carcinoma.

Prognostic factors in stage IA-IIA cervical cancer patients treated surgically: does the waiting time to the operation affect survival?

Expression and localization of CXCL16 and CXCR6 in ovarian endometriotic tissues.

The loss of endoglin promotes the invasion of extravillous trophoblasts.

Survival impact of capsule rupture in stage I clear cell carcinoma of the ovary in comparison with other histological types.

Fertility-sparing surgery in patients with clear-cell carcinoma of the ovary: is it possible?

Functional interaction between peritoneal mesothelial cells and stem cells of ovarian yolk sac tumor (SC-OYST) in peritoneal dissemination.

Survival impact of adjuvant paclitaxel and carboplatin for early-stage ovarian clear-cell carcinoma with complete surgical staging.

Expression of CXCR4 indicates poor prognosis in patients with clear cell carcinoma of the ovary.

Long-term clinical outcome of patients with recurrent epithelial ovarian carcinoma: is it the same for each histological type?

Diagnostic utility of CD117, CD133, SALL4, OCT4, TCL1 and glypican-3 in malignant germ cell tumors of the ovary.

Carbon ion radiotherapy for recurrent malignant transformation from mature cystic teratoma of the ovary.

Establishment of a human nonluteinized granulosa cell line that transitions from the gonadotropin-independent to the gonadotropin-dependent status.

Is there any association between retroperitoneal lymphadenectomy and survival benefit in advanced stage epithelial ovarian carcinoma patients?

Postrecurrent oncologic outcome of patients with ovarian clear cell carcinoma.

The ferroimmunomodulatory role of ectopic endometriotic stromal cells in ovarian endometriosis.

Normal human chorionic gonadotropin regression curves in uneventful postmolar patients.

Sphingosine-1-phosphate inhibits H2O2-induced granulosa cell apoptosis via the PI3K/Akt signaling pathway.

Adjuvant chemotherapy for stage i ovarian clear cell carcinoma: is it necessary for stage IA?

Validity of lamellar body count as a fetal lung maturity assessment in twin pregnancy.

Mesenchymal stromal cells of human umbilical cord Wharton's jelly accelerate wound healing by paracrine mechanisms.

Fertility and pregnancy-associated ß-cell proliferation in mice deficient in proglucagon-derived peptides.

Expression of Twist enhances risk of poor oncologic outcome in patients with stage Ib to II cervical carcinoma with lymphovascular space involvement.

Successful surgical management of a septate uterus constricted with leiomyomas: hysteroscopic metroplasty using a Foley catheter.

[Fertility-sparing surgery in epithelial ovarian cancer].

[The diagnosis and treatment for choriocarcinoma].

Anti-Müllerian hormone as a marker of ovarian reserve following chemotherapy in patients with gestational trophoblastic neoplasia.

Mucinous cystic neoplasm of the pancreas with severe dysplasia during pregnancy: case report and review of the literature.

ALX1 induces snail expression to promote epithelial-to-mesenchymal transition and invasion of ovarian cancer cells.

Anti-Müllerian hormone as a marker of ovarian reserve in patients with ovarian malignancies who have undergone fertility-preserving surgery and chemotherapy.

Expression of RET finger protein predicts chemoresistance in epithelial ovarian cancer.

Amniotic lamellar body count and congenital diaphragmatic hernia in humans and in a rat model.

Extremely poor postrecurrence oncological outcome for patients with recurrent mucinous ovarian cancer.

The expression and characterization of endoglin in uterine leiomyosarcoma.

Met is the most frequently amplified gene in endometriosis-associated ovarian clear cell adenocarcinoma and correlates with worsened prognosis.

Identification and molecular characterization of a new ovarian cancer susceptibility locus at 17q21.31.

One-year follow-up of serum antimüllerian hormone levels in patients with cystectomy: are different sequential changes due to different mechanisms causing damage to the ovarian reserve?

Possible involvement of CD10 in the development of endometriosis due to its inhibitory effects on CD44-dependent cell adhesion.

An HLA-modified ovarian cancer cell line induced CTL responses specific to an epitope derived from claudin-1 presented by HLA-A*24:02 molecules.

Altered expression of enzymes regulating the activity of endothelin-1 in the lower segment of the human amnion during labor.

Chronic peripheral administration of kappa-opioid receptor antagonist advances puberty onset associated with acceleration of pulsatile luteinizing hormone secretion in female rats.

A proteomic analysis of human follicular fluid: comparison between fertilized oocytes and non-fertilized oocytes in the same patient.

Management of eclampsia and stroke during pregnancy.

Effect of placenta previa on neonatal respiratory disorders and amniotic lamellar body counts at 36-38weeks of gestation.

Significant clinical response of progressive recurrent ovarian clear cell carcinoma to glypican-3-derived peptide vaccine therapy: two case reports.

A recurrence-predicting prognostic factor for patients with ovarian clear-cell adenocarcinoma at reproductive age.

Growing teratoma syndrome of the ovary showing three patterns of metastasis: a case report.

Effect of indirect nonequilibrium atmospheric pressure plasma on anti-proliferative activity against chronic chemo-resistant ovarian cancer cells in vitro and in vivo.

Expression of chromobox homolog 7 (CBX7) is associated with poor prognosis in ovarian clear cell adenocarcinoma via TRAIL-induced apoptotic pathway regulation.

Mitochondrial membrane potential in 2-cell stage embryos correlates with the success of preimplantation development.

Survival benefit of taxane plus platinum in recurrent ovarian cancer with non-clear cell, non-mucinous histology.

Ovarian mucinous tumors arising from mature cystic teratomas--a molecular genetic approach for understanding the cellular origin.

Recurrence-predicting prognostic factors for patients with early-stage epithelial ovarian cancer undergoing fertility-sparing surgery: a multi-institutional study.

Maternal molecular hydrogen administration ameliorates rat fetal hippocampal damage caused by in utero ischemia-reperfusion.

Suppression of REV7 enhances cisplatin sensitivity in ovarian clear cell carcinoma cells.

Is there any association between where patients spend the end of life and survival after anticancer treatment for gynecologic malignancy?

B7-H4 overexpression correlates with a poor prognosis for cervical cancer patients.

PLAGL2 regulates actin cytoskeletal architecture and cell migration.

Mutational analysis of FOXL2 p.C134W and expression of bone morphogenetic protein 2 in Japanese patients with granulosa cell tumor of ovary.

CYP51A1 induced by growth differentiation factor 9 and follicle-stimulating hormone in granulosa cells is a possible predictor for unfertilization.

Possible association between stem-like hallmark and radioresistance in human cervical carcinoma cells.

Clinicopathologic features of epithelial ovarian carcinoma in younger vs. older patients: analysis in Japanese women.

Pelvic tuberculous granuloma successfully treated with laparoscopy to preserve fertility: a case report and review of the published work.

Opioid needs of terminally ill patients with gynecologic malignancies.

Expression of the miR200 family of microRNAs in mesothelial cells suppresses the dissemination of ovarian cancer cells.

Identification of causative pregnancy of gestational trophoblastic neoplasia diagnosed during pregnancy by short tandem repeat analysis.

GPC3 expression in mouse ovarian cancer induces GPC3‑specific T cell-mediated immune response through M1 macrophages and suppresses tumor growth.

Impact of warning bleeding on the cortisol level in the fetus and neonatal RDS/TTN in cases of placenta previa.

Anti-Müllerian hormone as a possible predictor of fecundability in subfertile women over 38 years: a retrospective cohort study.

Unexpected ovarian malignancy found after laparoscopic surgery in patients with adnexal masses--a single institutional experience.

Selective cytotoxicity of indirect nonequilibrium atmospheric pressure plasma against ovarian clear-cell carcinoma.

Oncologic outcome after recurrence in patients with stage I epithelial ovarian cancer: are clear-cell and mucinous histological types a different entities?

Anti-Müllerian hormone and assessment of ovarian reserve after ovarian toxic treatment: a systematic narrative review.

Direct exposure of non-equilibrium atmospheric pressure plasma confers simultaneous oxidative and ultraviolet modifications in biomolecules.

Assessment of ovarian reserve using anti-Müllerian hormone levels in benign gynecologic conditions and surgical interventions: a systematic narrative review.

Amniotic lamellar body count: predicting and distinguishing neonatal respiratory complications in twin pregnancies.

Administration of standard-dose BEP regimen (bleomycin+etoposide+cisplatin) is essential for treatment of ovarian yolk sac tumour.

Plasma-activated medium suppresses choroidal neovascularization in mice: a new therapeutic concept for age-related macular degeneration.

Catalytic ferrous iron in amniotic fluid as a predictive marker of human maternal-fetal disorders.

Regulation of secondary follicle growth by theca cells and insulin-like growth factor 1.

Viral load in children with congenital cytomegalovirus infection identified on newborn hearing screening.

HOXB13 and ALX4 induce SLUG expression for the promotion of EMT and cell invasion in ovarian cancer cells.

Analysis of the Effect of Leukemia Inhibitory Factor on Follicular Growth in Cultured Murine Ovarian Tissue.

[Plasma-Activated Solution: Mechanism of Action, Clinical Application, and Industrialization].

Is the serum l-arginine level during early pregnancy a predictor of pregnancy-induced hypertension?

Relationship between the cortisol levels in umbilical cord blood and neonatal RDS/TTN in twin pregnancies.

The prognostic impact of pulmonary metastasectomy in recurrent gynecologic cancers: a retrospective single-institution study.

Risk assessment for neonatal RDS/TTN using gestational age and the amniotic lamellar body count in twin pregnancies.

Ovarian endometriosis-associated stromal cells reveal persistently high affinity for iron.

Maternal molecular hydrogen administration on lipopolysaccharide-induced mouse fetal brain injury.

Anti-Müllerian hormone levels after laparoscopic cystectomy for endometriomas as a possible predictor for pregnancy in infertility treatments.

Usefulness of the Ultrasensitive Anti-Müllerian Hormone Assay for Predicting True Ovarian Reserve.

A Randomized, Double-Blind Pilot Trial of Hydrolyzed Rice Bran versus Placebo for Radioprotective Effect on Acute Gastroenteritis Secondary to Chemoradiotherapy in Patients with Cervical Cancer.

Neuroprotective potential of molecular hydrogen against perinatal brain injury via suppression of activated microglia.

A prospective observational study on chemotherapy-induced nausea and vomiting (CINV) in patients with gynecologic cancer by the CINV Study Group of Japan.

Cell survival of glioblastoma grown in medium containing hydrogen peroxide and/or nitrite, or in plasma-activated medium.

Increase of kisspeptin-positive cells in the hypothalamus of a rat model of polycystic ovary syndrome.

Radiotherapy for persistent malignant transformation from mature cystic teratoma of the ovary.

Efficacy and safety of daikenchuto (TJ-100) in pregnant women with constipation.

Serum pentraxin 3 as a possible marker for mature cystic teratomas.

PRIMA-1MET induces apoptosis through accumulation of intracellular reactive oxygen species irrespective of p53 status and chemo-sensitivity in epithelial ovarian cancer cells.

Comparison of prognoses according to non-positive and positive spectrin αII expression detected immunohistochemically in epithelial ovarian carcinoma: a retrospective study.

Pain-reducing anesthesia prevents oxidative stress in human term placenta.

Variable susceptibility of ovarian cancer cells to non-thermal plasma-activated medium.

Antenatal Saireito (TJ-114) Can Improve Pulmonary Hypoplasia and Pulmonary Vascular Remodeling in Nitrofen-Induced Congenital Diaphragmatic Hernia.

Contrast-enhanced ultrasonography using Sonazoid(®) is useful for diagnosis of malignant ovarian tumors: comparison with Doppler ultrasound.

Non-thermal plasma prevents progression of endometriosis in mice.

Severe Hemoperitoneum During Pregnancy with Obstructed Hemivagina and Ipsilateral Renal Anomaly Syndrome: A Case Report.

Feasibility and benefit of concurrent chemoradiotherapy for elderly patients with uterine cervical cancer.

Oncologic and obstetric outcomes of early stage cervical cancer with abdominal radical trachelectomy: Single-institution experience.

Choosing the optimal therapeutic strategy for placental polyps using power Doppler color scoring: Transarterial embolization followed by hysteroscopic resection or expectant management?

Lipocalin 2 as a new biomarker for fetal lung hypoplasia in congenital diaphragmatic hernia.

Molecular hydrogen ameliorates several characteristics of preeclampsia in the Reduced Uterine Perfusion Pressure (RUPP) rat model.

Involvement of mesosalpinx in endometrioma is a possible risk factor for decrease of ovarian reserve after cystectomy: a retrospective cohort study.

An Analysis of Behavioral and Genetic Risk Factors for Chemotherapy-Induced Nausea and Vomiting in Japanese Subjects.

Non-thermal atmospheric pressure plasma activates lactate in Ringer's solution for anti-tumor effects.