Jose Javier Bravo-Cordero

Novel lambda FRET spectral confocal microscopy imaging method.

Specific tyrosine phosphorylation sites on cortactin regulate Nck1-dependent actin polymerization in invadopodia.

An EGFR-Src-Arg-cortactin pathway mediates functional maturation of invadopodia and breast cancer cell invasion.

A novel spatiotemporal RhoC activation pathway locally regulates cofilin activity at invadopodia.

Cortactin phosphorylation regulates cell invasion through a pH-dependent pathway.

Directed cell invasion and migration during metastasis.

Spatial regulation of RhoC activity defines protrusion formation in migrating cells.

Functions of cofilin in cell locomotion and invasion.

Live cell imaging of RhoGTPase biosensors in tumor cells.

Quantitative ratiometric imaging of FRET-biosensors in living cells.

Spatial regulation of tumor cell protrusions by RhoC.

A Trio-Rac1-Pak1 signalling axis drives invadopodia disassembly.

Talin regulates moesin-NHE-1 recruitment to invadopodia and promotes mammary tumor metastasis.

Intravital multiphoton imaging reveals multicellular streaming as a crucial component of in vivo cell migration in human breast tumors.

Rho GTPase isoforms in cell motility: Don't fret, we have FRET.

A Trio-Rac1-Pak1 signalling axis drives invadopodia disassembly.

Macrophage-dependent tumor cell transendothelial migration is mediated by Notch1/Mena(INV)-initiated invadopodium formation.

Phenotypic heterogeneity of disseminated tumour cells is preset by primary tumour hypoxic microenvironments.