Dipartimento di Scienze Medico-Veterinarie,
Department of Veterinary Science
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Potential of bovine herpesvirus 4 as a gene delivery vector.
Journal of virological methods Mar, 2002 | Pubmed ID: 11849683
Activation of bovine herpesvirus 4 lytic replication in a non-permissive cell line by overexpression of BoHV-4 immediate early (IE) 2 gene.
Journal of virological methods Mar, 2004 | Pubmed ID: 14738989
Bovine herpesvirus 4 infects differentiated neuronal cells in culture and establish persistent infection upon selection.
Journal of neurovirology Apr, 2004 | Pubmed ID: 15204931
Biologically active bisquaternary ammonium chlorides: physico-chemical properties of long chain amphiphiles and their evaluation as non-viral vectors for gene delivery.
Biochimica et biophysica acta Mar, 2005 | Pubmed ID: 15725392
Paracrine inhibition of prion propagation by anti-PrP single-chain Fv miniantibodies.
Journal of virology Jul, 2005 | Pubmed ID: 15956578
Potential secondary pathogenic role for bovine herpesvirus 4.
Journal of clinical microbiology Jul, 2005 | Pubmed ID: 16000468
Outcome of bovine herpesvirus 4 infection following direct viral injection in the lateral ventricle of the mouse brain.
Microbes and infection Mar, 2006 | Pubmed ID: 16503181
Bovine herpesvirus 4 based vector interaction with liver cells in vitro and in vivo.
Journal of virological methods Sep, 2006 | Pubmed ID: 16712963
Expression of bovine viral diarrhea virus glycoprotein E2 as a soluble secreted form in a Mammalian cell line.
Clinical and vaccine immunology : CVI Jun, 2006 | Pubmed ID: 16760329
Recombinant bovine herpesvirus 4 (BoHV-4) expressing glycoprotein D of BoHV-1 is immunogenic and elicits serum-neutralizing antibodies against BoHV-1 in a rabbit model.
Clinical and vaccine immunology : CVI Nov, 2006 | Pubmed ID: 16928886
Association between Coxiella burnetii seropositivity and abortion in dairy cattle of Northern Italy.
The new microbiologica Jul, 2006 | Pubmed ID: 17058789
DNA condensation and cell transfection properties of guanidinium calixarenes: dependence on macrocycle lipophilicity, size, and conformation.
Journal of the American Chemical Society Nov, 2006 | Pubmed ID: 17090036
Generation of a transposon insertion mutant library for bovine herpesvirus 4 cloned as a bacterial artificial chromosome by in vitro MuA based DNA transposition system.
Journal of virological methods Apr, 2007 | Pubmed ID: 17182112
First Serbian isolates of bovine herpesvirus 4 (BoHV-4) from a herd with a history of postpartum metritis.
The new microbiologica Jan, 2007 | Pubmed ID: 17319601
Bovine herpesvirus 4 is tropic for bovine endometrial cells and modulates endocrine function.
Reproduction (Cambridge, England) Jul, 2007 | Pubmed ID: 17641100
Production of Wnt inhibitors by myeloma cells: potential effects on canonical Wnt pathway in the bone microenvironment.
Cancer research Aug, 2007 | Pubmed ID: 17702698
The new tumor-suppressor gene inhibitor of growth family member 4 (ING4) regulates the production of proangiogenic molecules by myeloma cells and suppresses hypoxia-inducible factor-1 alpha (HIF-1alpha) activity: involvement in myeloma-induced angiogenesis.
Blood Dec, 2007 | Pubmed ID: 17848618
Establishment of a bovine herpesvirus 4 based vector expressing a secreted form of the bovine viral diarrhoea virus structural glycoprotein E2 for immunization purposes.
BMC biotechnology Oct, 2007 | Pubmed ID: 17945009
Assessment of bovine herpesvirus 4 based vector in chicken.
Journal of virological methods Mar, 2008 | Pubmed ID: 18243344
Transduction of the rat brain by Bovine Herpesvirus 4.
Genetic vaccines and therapy Feb, 2008 | Pubmed ID: 18267037
Bacterial infection of endometrial stromal cells influences bovine herpesvirus 4 immediate early gene activation: a new insight into bacterial and viral interaction for uterine disease.
Reproduction (Cambridge, England) Sep, 2008 | Pubmed ID: 18577555
Thermodynamics and biological properties of the aqueous solutions of new glucocationic surfactants.
The journal of physical chemistry. B Aug, 2008 | Pubmed ID: 18616333
Macrocyclic nonviral vectors: high cell transfection efficiency and low toxicity in a lower rim guanidinium calix[4]arene.
Organic letters Sep, 2008 | Pubmed ID: 18722463
Double immunization strategy with a BoHV-4-vectorialized secreted chimeric peptide BVDV-E2/BoHV-1-gD.
Vaccine Nov, 2008 | Pubmed ID: 18812200
Bovine endometrial stromal cells display osteogenic properties.
Reproductive biology and endocrinology : RB&E Dec, 2008 | Pubmed ID: 19087287
Defining postpartum uterine disease and the mechanisms of infection and immunity in the female reproductive tract in cattle.
Biology of reproduction Dec, 2009 | Pubmed ID: 19439727
Isolation and characterization of bovine herpesvirus 4 (BoHV-4) from a cow affected by post partum metritis and cloning of the genome as a bacterial artificial chromosome.
Reproductive biology and endocrinology : RB&E Aug, 2009 | Pubmed ID: 19691825
Cellular targeting of engineered heterologous antigens is a determinant factor for bovine herpesvirus 4-based vaccine vector development.
Clinical and vaccine immunology : CVI Nov, 2009 | Pubmed ID: 19793901
Isolation and characterization of a strain of Lichtheimia corymbifera (ex Absidia corymbifera) from a case of bovine abortion.
Reproductive biology and endocrinology : RB&E Nov, 2009 | Pubmed ID: 19948023
The chemokine IL8 is up-regulated in bovine endometrial stromal cells by the BoHV-4 IE2 gene product, ORF50/Rta: a step ahead toward a mechanism for BoHV-4 induced endometritis.
Biology of reproduction Dec, 2010 | Pubmed ID: 20720165
Integration of bovine herpesvirus 4 genome into cultured persistently infected host cell genome.
Virology journal Sep, 2010 | Pubmed ID: 20854697
Virally and physically transgenized equine adipose-derived stromal cells as a cargo for paracrine secreted factors.
BMC cell biology Sep, 2010 | Pubmed ID: 20863390
Bovine herpesvirus 4 immediate early 2 (Rta) gene is an essential gene and is duplicated in bovine herpesvirus 4 isolate U.
Veterinary microbiology Mar, 2011 | Pubmed ID: 21035279
Bovine herpesvirus 4 based vector as a potential oncolytic-virus for treatment of glioma.
Virology journal Nov, 2010 | Pubmed ID: 21047419
Swine adipose stromal cells loaded with recombinant bovine herpesvirus 4 virions expressing a foreign antigen induce potent humoral immune responses in pigs.
Vaccine Jan, 2011 | Pubmed ID: 21115049
Immunization of knock-out α/β interferon receptor mice against lethal bluetongue infection with a BoHV-4-based vector expressing BTV-8 VP2 antigen.
Vaccine Apr, 2011 | Pubmed ID: 21320537
Herpes simplex virus type 1 thymidine kinase-armed bovine herpesvirus type 4-based vector displays enhanced oncolytic properties in immunocompetent orthotopic syngenic mouse and rat glioma models.
Neuro-oncology Mar, 2012 | Pubmed ID: 22228853
Lower rim guanidinocalix[4]arenes: macrocyclic nonviral vectors for cell transfection.
Bioconjugate chemistry May, 2012 | Pubmed ID: 22463059
In vivo imaging of transiently transgenized mice with a bovine interleukin 8 (CXCL8) promoter/luciferase reporter construct.
PloS one , 2012 | Pubmed ID: 22761878
Clinical protection of goats against CpHV-1 induced genital disease with a BoHV-4-based vector expressing CpHV-1 gD.
PloS one , 2013 | Pubmed ID: 23300989
Bovine herpesvirus 4 glycoprotein B is indispensable for lytic replication and irreplaceable by VSVg.
BMC veterinary research Jan, 2013 | Pubmed ID: 23302472
Characterization of caprine herpesvirus 1 (CpHV1) glycoprotein E and glycoprotein I ectodomains expressed in mammalian cells.
Veterinary microbiology Jun, 2013 | Pubmed ID: 23490557
Bovine endometrial stromal cells support tumor necrosis factor alpha-induced bovine herpesvirus type 4 enhanced replication.
Biology of reproduction May, 2013 | Pubmed ID: 23515672
Arginine clustering on calix[4]arene macrocycles for improved cell penetration and DNA delivery.
Nature communications , 2013 | Pubmed ID: 23591888
Efficient heterologous antigen gene delivery and expression by a replication-attenuated BoHV-4-based vaccine vector.
Vaccine Aug, 2013 | Pubmed ID: 23830977
Aurora and IKK kinases cooperatively interact to protect multiple myeloma cells from Apo2L/TRAIL.
Blood Oct, 2013 | Pubmed ID: 23974204
Enlightened Mannhemia haemolytica lung inflammation in bovinized mice.
Veterinary research Jan, 2014 | Pubmed ID: 24460618
In vivo image analysis of BoHV-4-based vector in mice.
PloS one , 2014 | Pubmed ID: 24752229
Retinal transduction profiles by high-capacity viral vectors.
Gene therapy Oct, 2014 | Pubmed ID: 24989814
Generation and characterization of the first immortalized alpaca cell line suitable for diagnostic and immunization studies.
PloS one , 2014 | Pubmed ID: 25140515
Interferon gamma-mediated BoHV-4 replication restriction in bovine endometrial stromal cells is host IDO1 gene expression independent and BoHV-4 IE2 gene expression dependent.
Biology of reproduction Nov, 2014 | Pubmed ID: 25273529
Nonviral gene delivery: gemini bispyridinium surfactant-based DNA nanoparticles.
The journal of physical chemistry. B Nov, 2014 | Pubmed ID: 25340646
Cyclodextrin- and calixarene-based polycationic amphiphiles as gene delivery systems: a structure-activity relationship study.
Organic & biomolecular chemistry Feb, 2015 | Pubmed ID: 25474077
Azithromycin inhibits nuclear factor-κB activation during lung inflammation: an in vivo imaging study.
Pharmacology research & perspectives Oct, 2014 | Pubmed ID: 25505605
BoHV-4-Based Vector Single Heterologous Antigen Delivery Protects STAT1(-/-) Mice from Monkeypoxvirus Lethal Challenge.
PLoS neglected tropical diseases Jun, 2015 | Pubmed ID: 26086739
In vivo imaging of the lung inflammatory response to Pseudomonas aeruginosa and its modulation by azithromycin.
Journal of translational medicine Aug, 2015 | Pubmed ID: 26239109
BoHV-4 immediate early 1 gene is a dispensable gene and its product is not a bone marrow stromal cell antigen 2 counteracting factor.
BMC veterinary research Aug, 2015 | Pubmed ID: 26307352
The anti-tumoral effect of lenalidomide is increased in vivo by hypoxia-inducible factor (HIF)-1α inhibition in myeloma cells.
Haematologica Mar, 2016 | Pubmed ID: 26659917
Bovine herpesvirus 4-based vector delivering a hybrid rat/human HER-2 oncoantigen efficiently protects mice from autochthonous Her-2(+) mammary cancer.
Oncoimmunology Mar, 2016 | Pubmed ID: 27141335
Dependence on glutamine uptake and glutamine addiction characterize myeloma cells: a new attractive target.
Blood Aug, 2016 | Pubmed ID: 27268090
A chimeric protein comprising the immunogenic domains of Mannheimia haemolytica leukotoxin and outer membrane protein PlpE induces antibodies against leukotoxin and PlpE.
Veterinary immunology and immunopathology Jul, 2016 | Pubmed ID: 27269790
Virus-Mediated Metalloproteinase 1 Induction Revealed by Transcriptome Profiling of Bovine Herpesvirus 4-Infected Bovine Endometrial Stromal Cells.
Biology of reproduction Jul, 2016 | Pubmed ID: 27281703
In vivo monitoring of lung inflammation in CFTR-deficient mice.
Journal of translational medicine Jul, 2016 | Pubmed ID: 27468800
Nonviral gene-delivery by highly fluorinated gemini bispyridinium surfactant-based DNA nanoparticles.
Journal of colloid and interface science Feb, 2017 | Pubmed ID: 27769002
BoHV-4-based vector delivering Ebola virus surface glycoprotein.
Journal of translational medicine Nov, 2016 | Pubmed ID: 27881138
IL21R expressing CD14(+)CD16(+) monocytes expand in multiple myeloma patients leading to increased osteoclasts.
Haematologica Apr, 2017 | Pubmed ID: 28057743
Interleukin 8 haplotypes drive divergent responses in uterine endometrial cells and are associated with somatic cell score in Holstein-Friesian cattle.
Veterinary immunology and immunopathology Feb, 2017 | Pubmed ID: 28166928
Immunization of bighorn sheep against Mannheimia haemolytica with a bovine herpesvirus 1-vectored vaccine.
Vaccine Mar, 2017 | Pubmed ID: 28228321
Heterologous Matrix Metalloproteinase Gene Promoter Activity Allows In Vivo Real-time Imaging of Bleomycin-Induced Lung Fibrosis in Transiently Transgenized Mice.
Frontiers in immunology , 2017 | Pubmed ID: 28298912
Bovine herpes virus type 4 alters TNF-α and IL-8 profiles and impairs the survival of bovine endometrial epithelial cells.
Reproductive biology May, 2017 | Pubmed ID: 28546031
Assessment and optimization of Theileria parva sporozoite full-length p67 antigen expression in mammalian cells.
PLoS neglected tropical diseases Aug, 2017 | Pubmed ID: 28800590
Coordinated Role of Toll-Like Receptor-3 and Retinoic Acid-Inducible Gene-I in the Innate Response of Bovine Endometrial Cells to Virus.
Frontiers in immunology , 2017 | Pubmed ID: 28878771
Induction of Antihuman C-C Chemokine Receptor Type 5 Antibodies by a Bovine Herpesvirus Type-4 Based Vector.
Frontiers in immunology , 2017 | Pubmed ID: 29118763
Bovine Herpesvirus-4-Based Vector Delivering Peste des Petits Ruminants Virus Hemagglutinin ORF Induces both Neutralizing Antibodies and Cytotoxic T Cell Responses.
Frontiers in immunology , 2018 | Pubmed ID: 29556236
Gabriella Bergamini*,1,
Fabio Stellari*,2,
Angela Sandri*,3,
Maria M. Lleo3,
Gaetano Donofrio4,
Francesca Ruscitti5,2,
Federico Boschi6,
Andrea Sbarbati7,
Gino Villetti2,
Paola Melotti8,
Claudio Sorio1
1Department of Medicine, General Pathology Division, Cystic Fibrosis Translational Research Laboratory "D. Lissandrini", University of Verona,
2Corporate Preclinical R&D, Chiesi Farmaceutici S.p.A.,
3Department of Diagnostic and Public Health, Microbiology Division, University of Verona,
4Dipartimento di Scienze Medico-Veterinarie, University of Parma,
5Department of Biomedical Biotechnological and Translational Sciences, University of Parma,
6Department of Computer Science, University of Verona,
7Department of Neurological, Biomedical and Movement Sciences, University of Verona,
8Cystic Fibrosis Regional Center (CFC), AOUI Verona