Centre for Prions and Protein Folding Diseases & Department of Biochemistry
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Molecular modeling of the misfolded insulin subunit and amyloid fibril.
Biophysical journal Dec, 2009 | Pubmed ID: 20006956
Structural studies of the scrapie prion protein by electron crystallography.
Proceedings of the National Academy of Sciences of the United States of America Mar, 2002 | Pubmed ID: 11891310
Cytosolic prion protein in neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience Aug, 2003 | Pubmed ID: 12904479
Evidence for assembly of prions with left-handed beta-helices into trimers.
Proceedings of the National Academy of Sciences of the United States of America Jun, 2004 | Pubmed ID: 15155909
Engineering a 2D protein-DNA crystal.
Angewandte Chemie (International ed. in English) May, 2005 | Pubmed ID: 15828044
Assembly of natural and recombinant prion protein into fibrils.
Biological chemistry Jun, 2005 | Pubmed ID: 16006244
Human prions and plasma lipoproteins.
Proceedings of the National Academy of Sciences of the United States of America Jul, 2006 | Pubmed ID: 16849426
Influence of water, fat, and glycerol on the mechanism of thermal prion inactivation.
The Journal of biological chemistry Dec, 2007 | Pubmed ID: 17878157
Electron crystallography of the scrapie prion protein complexed with heavy metals.
Archives of biochemistry and biophysics Nov, 2007 | Pubmed ID: 17935686
Small-molecule aggregates inhibit amyloid polymerization.
Nature chemical biology Mar, 2008 | Pubmed ID: 18223646
Mechanisms of prion protein assembly into amyloid.
Proceedings of the National Academy of Sciences of the United States of America Feb, 2008 | Pubmed ID: 18268326
Genes contributing to prion pathogenesis.
The Journal of general virology Jul, 2008 | Pubmed ID: 18559949
Conformational diversity of wild-type Tau fibrils specified by templated conformation change.
The Journal of biological chemistry Feb, 2009 | Pubmed ID: 19010781
Cryo-immunogold electron microscopy for prions: toward identification of a conversion site.
The Journal of neuroscience : the official journal of the Society for Neuroscience Nov, 2008 | Pubmed ID: 19020041
Surface charge of polyoxometalates modulates polymerization of the scrapie prion protein.
Proceedings of the National Academy of Sciences of the United States of America Mar, 2009 | Pubmed ID: 19223590
Evolutionary descent of prion genes from the ZIP family of metal ion transporters.
PloS one Sep, 2009 | Pubmed ID: 19784368
Natural and synthetic prion structure from X-ray fiber diffraction.
Proceedings of the National Academy of Sciences of the United States of America Oct, 2009 | Pubmed ID: 19805070
Design and construction of diverse mammalian prion strains.
Proceedings of the National Academy of Sciences of the United States of America Dec, 2009 | Pubmed ID: 19915150
Colloid formation by drugs in simulated intestinal fluid.
Journal of medicinal chemistry May, 2010 | Pubmed ID: 20426472
Family reunion--the ZIP/prion gene family.
Progress in neurobiology Mar, 2011 | Pubmed ID: 21163327
In vitro conversion and seeded fibrillization of posttranslationally modified prion protein.
Biological chemistry May, 2011 | Pubmed ID: 21476870
Self-assembling small molecules form nanofibrils that bind procaspase-3 to promote activation.
Journal of the American Chemical Society Dec, 2011 | Pubmed ID: 22066605
Spontaneous generation of anchorless prions in transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America Dec, 2011 | Pubmed ID: 22160704
Protease-resistant prions selectively decrease Shadoo protein.
PLoS pathogens Nov, 2011 | Pubmed ID: 22163178
Prion uptake in the gut: identification of the first uptake and replication sites.
PLoS pathogens Dec, 2011 | Pubmed ID: 22216002
Degradation of fungal prion HET-s(218-289) induces formation of a generic amyloid fold.
Biophysical journal May, 2012 | Pubmed ID: 22677387
Plasma membrane invaginations containing clusters of full-length PrPSc are an early form of prion-associated neuropathology in vivo.
Neurobiology of aging Jun, 2013 | Pubmed ID: 23481568
The ZIP5 ectodomain co-localizes with PrP and may acquire a PrP-like fold that assembles into a dimer.
PloS one , 2013 | Pubmed ID: 24039764
The structure of the infectious prion protein: experimental data and molecular models.
Prion Jan-Feb, 2014 | Pubmed ID: 24583975
The structure of human prions: from biology to structural models-considerations and pitfalls.
Viruses Oct, 2014 | Pubmed ID: 25333467
Octarepeat region flexibility impacts prion function, endoproteolysis and disease manifestation.
EMBO molecular medicine Mar, 2015 | Pubmed ID: 25661904
Subcellular distribution of the prion protein in sickness and in health.
Virus research Sep, 2015 | Pubmed ID: 25683509
Mechanism of scrapie prion precipitation with phosphotungstate anions.
ACS chemical biology May, 2015 | Pubmed ID: 25695325
Structural studies of truncated forms of the prion protein PrP.
Biophysical journal Mar, 2015 | Pubmed ID: 25809267
Deer Prion Proteins Modulate the Emergence and Adaptation of Chronic Wasting Disease Strains.
Journal of virology Dec, 2015 | Pubmed ID: 26423950
Toll-like receptor-mediated immune response inhibits prion propagation.
Glia Jun, 2016 | Pubmed ID: 26880394
The Detection of Infectious Prions: In Vitro Conversion Assays Change the (Folding) Landscape.
The Journal of molecular diagnostics : JMD May, 2016 | Pubmed ID: 27020948
Secretory pathway retention of mutant prion protein induces p38-MAPK activation and lethal disease in mice.
Scientific reports Apr, 2016 | Pubmed ID: 27117504
A Neuronal Culture System to Detect Prion Synaptotoxicity.
PLoS pathogens May, 2016 | Pubmed ID: 27227882
Neuroinvasion of α-Synuclein Prionoids after Intraperitoneal and Intraglossal Inoculation.
Journal of virology Oct, 2016 | Pubmed ID: 27489279
The Structural Architecture of an Infectious Mammalian Prion Using Electron Cryomicroscopy.
PLoS pathogens Sep, 2016 | Pubmed ID: 27606840