Holger Wille

Molecular modeling of the misfolded insulin subunit and amyloid fibril.

Structural studies of the scrapie prion protein by electron crystallography.

Cytosolic prion protein in neurons.

Evidence for assembly of prions with left-handed beta-helices into trimers.

Engineering a 2D protein-DNA crystal.

Assembly of natural and recombinant prion protein into fibrils.

Human prions and plasma lipoproteins.

Influence of water, fat, and glycerol on the mechanism of thermal prion inactivation.

Electron crystallography of the scrapie prion protein complexed with heavy metals.

Small-molecule aggregates inhibit amyloid polymerization.

Mechanisms of prion protein assembly into amyloid.

Genes contributing to prion pathogenesis.

Conformational diversity of wild-type Tau fibrils specified by templated conformation change.

Cryo-immunogold electron microscopy for prions: toward identification of a conversion site.

Surface charge of polyoxometalates modulates polymerization of the scrapie prion protein.

Evolutionary descent of prion genes from the ZIP family of metal ion transporters.

Natural and synthetic prion structure from X-ray fiber diffraction.

Design and construction of diverse mammalian prion strains.

Colloid formation by drugs in simulated intestinal fluid.

Family reunion--the ZIP/prion gene family.

In vitro conversion and seeded fibrillization of posttranslationally modified prion protein.

Self-assembling small molecules form nanofibrils that bind procaspase-3 to promote activation.

Spontaneous generation of anchorless prions in transgenic mice.

Protease-resistant prions selectively decrease Shadoo protein.

Prion uptake in the gut: identification of the first uptake and replication sites.

Degradation of fungal prion HET-s(218-289) induces formation of a generic amyloid fold.

Plasma membrane invaginations containing clusters of full-length PrPSc are an early form of prion-associated neuropathology in vivo.

The ZIP5 ectodomain co-localizes with PrP and may acquire a PrP-like fold that assembles into a dimer.

The structure of the infectious prion protein: experimental data and molecular models.

The structure of human prions: from biology to structural models-considerations and pitfalls.

Octarepeat region flexibility impacts prion function, endoproteolysis and disease manifestation.

Subcellular distribution of the prion protein in sickness and in health.

Mechanism of scrapie prion precipitation with phosphotungstate anions.

Structural studies of truncated forms of the prion protein PrP.

Deer Prion Proteins Modulate the Emergence and Adaptation of Chronic Wasting Disease Strains.

Toll-like receptor-mediated immune response inhibits prion propagation.

The Detection of Infectious Prions: In Vitro Conversion Assays Change the (Folding) Landscape.

Secretory pathway retention of mutant prion protein induces p38-MAPK activation and lethal disease in mice.

A Neuronal Culture System to Detect Prion Synaptotoxicity.

Neuroinvasion of α-Synuclein Prionoids after Intraperitoneal and Intraglossal Inoculation.

The Structural Architecture of an Infectious Mammalian Prion Using Electron Cryomicroscopy.