Masahide Takahashi

The GDNF/RET signaling pathway and human diseases.

Role for O-glycosylation of RFP in the interaction with enhancer of polycomb.

Novel mechanism of regulation of Rac activity and lamellipodia formation by RET tyrosine kinase.

Evidence of both extra- and intracellular cysteine targets of protein modification for activation of RET kinase.

Repair by Src kinase of function-impaired RET with multiple endocrine neoplasia type 2A mutation with substitutions of tyrosines in the COOH-terminal kinase domain for phenylalanine.

Activation of RET tyrosine kinase regulates interleukin-8 production by multiple signaling pathways.

Role of Dok1 in cell signaling mediated by RET tyrosine kinase.

Characterization of gene expression induced by RET with MEN2A or MEN2B mutation.

Overexpression of interleukin-15 prevents the development of murine retrovirus-induced acquired immunodeficiency syndrome.

Differential expression of RET finger protein in testicular germ cell tumors.

Cys611Ser mutation in RET proto-oncogene in a kindred with medullary thyroid carcinoma and Hirschsprung's disease.

Identification of a novel glial cell line-derived neurotrophic factor-inducible gene required for renal branching morphogenesis.

Mi-2 beta associates with BRG1 and RET finger protein at the distinct regions with transcriptional activating and repressing abilities.

Establishment and characterization of mouse mammary carcinoma cell lines expressing RET with a multiple endocrine neoplasia 2A mutation.

Identification of RET autophosphorylation sites by mass spectrometry.

c-Kit-targeting immunotherapy for hereditary melanoma in a mouse model.

RET and neuroendocrine tumors.

Expression of CD109 in human cancer.

Induction of CRMP-2 by GDNF and analysis of the CRMP-2 promoter region.

Expression cloning of oligomerization-activated genes with cell-proliferating potency by pseudotype retrovirus vector.

A targeting mutation of tyrosine 1062 in Ret causes a marked decrease of enteric neurons and renal hypoplasia.

Biochemical and biological responses induced by coupling of Gab1 to phosphatidylinositol 3-kinase in RET-expressing cells.

Identification of a mouse cytoskeleton-associated protein, CKAP2, with microtubule-stabilizing properties.

Targeted disruption of mouse ortholog of the human MYH9 responsible for macrothrombocytopenia with different organ involvement: hematological, nephrological, and otological studies of heterozygous KO mice.

The RET proto-oncogene: a molecular therapeutic target in thyroid cancer.

CD109 expression in squamous cell carcinoma of the uterine cervix.

PIAS proteins are involved in the SUMO-1 modification, intracellular translocation and transcriptional repressive activity of RET finger protein.

Activation of c-Jun amino-terminal kinase by GDNF induces G2/M cell cycle delay linked with actin reorganization.

GDNF-inducible zinc finger protein 1 is a sequence-specific transcriptional repressor that binds to the HOXA10 gene regulatory region.

Akt/PKB regulates actin organization and cell motility via Girdin/APE.

Microspherule protein 1, Mi-2beta, and RET finger protein associate in the nucleolus and up-regulate ribosomal gene transcription.

A PKC-mediated backup mechanism of the MXXCW motif-linked switch for initiating tyrosine kinase activities.

Analyses of ultraviolet-induced focus formation of hREV1 protein.

RET receptor signaling: dysfunction in thyroid cancer and Hirschsprung's disease.

Dok-4 regulates GDNF-dependent neurite outgrowth through downstream activation of Rap1 and mitogen-activated protein kinase.

RET and neuroendocrine tumors.

Targeted mutation of serine 697 in the Ret tyrosine kinase causes migration defect of enteric neural crest cells.

Girdin, a novel actin-binding protein, and its family of proteins possess versatile functions in the Akt and Wnt signaling pathways.

Sprouty2 regulates growth and differentiation of human neuroblastoma cells through RET tyrosine kinase.

Polycomb protein Cbx4 promotes SUMO modification of de novo DNA methyltransferase Dnmt3a.

CD109, a new marker for myoepithelial cells of mammary, salivary, and lacrimal glands and prostate basal cells.

RET signaling-induced SPHK1 gene expression plays a role in both GDNF-induced differentiation and MEN2-type oncogenesis.

Nucleolin modulates the subcellular localization of GDNF-inducible zinc finger protein 1 and its roles in transcription and cell proliferation.

Thermodynamic instability of siRNA duplex is a prerequisite for dependable prediction of siRNA activities.

High-level expression of CD109 is frequently detected in lung squamous cell carcinomas.

A novel GDNF-inducible gene, BMZF3, encodes a transcriptional repressor associated with KAP-1.

Regulation of VEGF-mediated angiogenesis by the Akt/PKB substrate Girdin.

An actin-binding protein Girdin regulates the motility of breast cancer cells.

GDNF-mediated signaling via RET tyrosine 1062 is essential for maintenance of spermatogonial stem cells.

CD109 expression in basal-like breast carcinoma.

Up-regulation of CD109 expression is associated with carcinogenesis of the squamous epithelium of the oral cavity.

Cell biology of the movement of breast cancer cells: intracellular signalling and the actin cytoskeleton.

Characterization of the HDAC1 complex that regulates the sensitivity of cancer cells to oxidative stress.

Adiponectin promotes migration activities of endothelial progenitor cells via Cdc42/Rac1.

Expression of Ret finger protein correlates with outcomes in endometrial cancer.

Ret-dependent cell rearrangements in the Wolffian duct epithelium initiate ureteric bud morphogenesis.

Roles of disrupted-in-schizophrenia 1-interacting protein girdin in postnatal development of the dentate gyrus.

Etv4 and Etv5 are required downstream of GDNF and Ret for kidney branching morphogenesis.

Girding for migratory cues: roles of the Akt substrate Girdin in cancer progression and angiogenesis.

Analysis of DOK-6 function in downstream signaling of RET in human neuroblastoma cells.

c-Ret-mediated hearing loss in mice with Hirschsprung disease.

Correlation of pathological grade and tumor stage of urothelial carcinomas with CD109 expression.

Loss of Sprouty2 partially rescues renal hypoplasia and stomach hypoganglionosis but not intestinal aganglionosis in Ret Y1062F mutant mice.

Protective role of Gipie, a Girdin family protein, in endoplasmic reticulum stress responses in endothelial cells.

Analysis of glial cell line-derived neurotrophic factor-inducible zinc finger protein 1 expression in human diseased kidney.

The actin-binding protein Girdin and its Akt-mediated phosphorylation regulate neointima formation after vascular injury.

Girdin is an intrinsic regulator of neuroblast chain migration in the rostral migratory stream of the postnatal brain.

Behavioral alterations associated with targeted disruption of exons 2 and 3 of the Disc1 gene in the mouse.

Proteomic analysis of hippocampal proteins of F344 rats exposed to 1-bromopropane.

Poly(A) tail length of neurohypophysial hormones is shortened under endoplasmic reticulum stress.

Role of palladin phosphorylation by extracellular signal-regulated kinase in cell migration.

RET finger protein expression is associated with prognosis in lung cancer with epidermal growth factor receptor mutations.

Indoxyl sulfate promotes vascular smooth muscle cell senescence with upregulation of p53, p21, and prelamin A through oxidative stress.

Involvement of Girdin in the determination of cell polarity during cell migration.

The Dishevelled-associating protein Daple controls the non-canonical Wnt/Rac pathway and cell motility.

Misshapen-like kinase 1 (MINK1) is a novel component of striatin-interacting phosphatase and kinase (STRIPAK) and is required for the completion of cytokinesis.

Exposure to 1-bromopropane induces microglial changes and oxidative stress in the rat cerebellum.

Epidermal hyperplasia and appendage abnormalities in mice lacking CD109.

Similar phenotypes of Girdin germ-line and conditional knockout mice indicate a crucial role for Girdin in the nestin lineage.

Girdin and its phosphorylation dynamically regulate neonatal vascular development and pathological neovascularization in the retina.

Expression of RET finger protein predicts chemoresistance in epithelial ovarian cancer.

The REV7 subunit of DNA polymerase ζ is essential for primordial germ cell maintenance in the mouse.

The Aurora-B-mediated phosphorylation of SHCBP1 regulates cytokinetic furrow ingression.

Mycobacterium tuberculosis escapes from the phagosomes of infected human osteoclasts reprograms osteoclast development via dysregulation of cytokines and chemokines.

Role of Girdin in intimal hyperplasia in vein grafts and efficacy of atelocollagen-mediated application of small interfering RNA for vein graft failure.

The impact of Girdin expression on recurrence-free survival in patients with luminal-type breast cancer.

Degeneration of retinal on bipolar cells induced by serum including autoantibody against TRPM1 in mouse model of paraneoplastic retinopathy.

Silencing of TBC1D15 promotes RhoA activation and membrane blebbing.

Detection of a soluble form of CD109 in serum of CD109 transgenic and tumor xenografted mice.

Suppression of REV7 enhances cisplatin sensitivity in ovarian clear cell carcinoma cells.

TRIM27/MRTF-B-dependent integrin β1 expression defines leading cells in cancer cell collectives.

High glucose impairs the proliferation and increases the apoptosis of endothelial progenitor cells by suppression of Akt.

Regulation of cargo-selective endocytosis by dynamin 2 GTPase-activating protein girdin.

Activating transcription factor 6α is required for the vasopressin neuron system to maintain water balance under dehydration in male mice.

Girdin phosphorylation is crucial for synaptic plasticity and memory: a potential role in the interaction of BDNF/TrkB/Akt signaling with NMDA receptor.

Special AT-rich sequence-binding protein 2 suppresses invadopodia formation in HCT116 cells via palladin inhibition.

SATB2 suppresses the progression of colorectal cancer cells via inactivation of MEK5/ERK5 signaling.

Girdin is phosphorylated on tyrosine 1798 when associated with structures required for migration.

CD109 attenuates TGF-β1 signaling and enhances EGF signaling in SK-MG-1 human glioblastoma cells.

Evaluation of androgen receptor and GATA binding protein 3 as immunohistochemical markers in the diagnosis of metastatic breast carcinoma to the lung.

Akt-Girdin signaling in cancer-associated fibroblasts contributes to tumor progression.

New endoplasmic reticulum stress regulator, Gipie, regulates the survival of vascular smooth muscle cells and the neointima formation after vascular injury.

Girdin/GIV regulates transendothelial permeability by controlling VE-cadherin trafficking through the small GTPase, R-Ras.

Rabphilin-3A as a Targeted Autoantigen in Lymphocytic Infundibulo-neurohypophysitis.

Potential involvement of kinesin-1 in the regulation of subcellular localization of Girdin.

A Novel Approach against Vascular Intimal Hyperplasia Through the Suppression of Girdin.

Akt-dependent Girdin phosphorylation regulates repair processes after acute myocardial infarction.

Role for Daple in non-canonical Wnt signaling during gastric cancer invasion and metastasis.

Akt-Girdin as oncotarget.

CD109 is a component of exosome secreted from cultured cells.

Collective invasion of cancer: Perspectives from pathology and development.

CCDC88A mutations cause PEHO-like syndrome in humans and mouse.

Identification of Meflin as a Potential Marker for Mesenchymal Stromal Cells.

Increased expression levels of ppGalNAc-T13 in lung cancers: Significance in the prognostic diagnosis.

Suppression of skin tumorigenesis in CD109-deficient mice.

Well-differentiated neuroendocrine tumor of the breast with extensive lymphatic and vascular infiltration.

[Corrigendum] Increased expression levels of ppGalNAc-T13 in lung cancers: Significance in the prognostic diagnosis.

Tyrosine Phosphorylation of an Actin-Binding Protein Girdin Specifically Marks Tuft Cells in Human and Mouse Gut.

Significance of low mTORC1 activity in defining the characteristics of brain tumor stem cells.

Daple Coordinates Planar Polarized Microtubule Dynamics in Ependymal Cells and Contributes to Hydrocephalus.

Significance of perivascular tumour cells defined by CD109 expression in progression of glioma.

ASC amino acid transporter 2, defined by enzyme-mediated activation of radical sources, enhances malignancy of GD2-positive small-cell lung cancer.

Critical role of rabphilin-3A in the pathophysiology of experimental lymphocytic neurohypophysitis.

Development of a method to preliminarily embed tissue samples using low melting temperature fish gelatin before sectioning: A technical note.

Negative regulation of amino acid signaling by MAPK-regulated 4F2hc/Girdin complex.

Essential Role of Linx/Islr2 in the Development of the Forebrain Anterior Commissure.

CD109 deficiency induces osteopenia with an osteoporosis-like phenotype in vivo.

Septin-dependent remodeling of cortical microtubule drives cell reshaping during epithelial wound healing.

Girdin/GIV regulates collective cancer cell migration by controlling cell adhesion and cytoskeletal organization.

Chemerin promotes angiogenesis in vivo.

Cancer-associated fibroblasts in gastrointestinal cancer.

Dephosphorylation of Girdin by PP2A inhibits breast cancer metastasis.

CD109: a multifunctional GPI-anchored protein with key roles in tumor progression and physiological homeostasis.

Roles of the Mesenchymal Stromal/Stem Cell Marker Meflin in Cardiac Tissue Repair and the Development of Diastolic Dysfunction.

Meflin-Positive Cancer-Associated Fibroblasts Inhibit Pancreatic Carcinogenesis.

The Significance of Molecular Biomarkers on Clinical Survival Outcome Differs Depending on Colon Cancer Sidedness.

Cancer-associated fibroblasts that restrain cancer progression: Hypotheses and perspectives.

Cytoplasmic Dynein Functions in Planar Polarization of Basal Bodies within Ciliated Cells.

Inactivation of REV7 enhances chemosensitivity and overcomes acquired chemoresistance in testicular germ cell tumors.

Detection of serum/salivary exosomal Alix in patients with oral squamous cell carcinoma.

Intracellular RET signaling pathways activated by GDNF.

Complex roles of the actin-binding protein Girdin/GIV in DNA damage-induced apoptosis of cancer cells.

The Daple-CK1ε complex regulates Dvl2 phosphorylation and canonical Wnt signaling.

CD109 regulates in vivo tumor invasion in lung adenocarcinoma through TGF-β signaling.

Roles of the Proto-oncogene in Cancer and Development.

Hair graying with aging in mice carrying oncogenic RET.

The Balance of Stromal BMP Signaling Mediated by GREM1 and ISLR Drives Colorectal Carcinogenesis.

Conditional Ror1 knockout reveals crucial involvement in lung adenocarcinoma development and identifies novel HIF-1α regulator.

Loss-of-function mutation of c-Ret causes cerebellar hypoplasia in mice with Hirschsprung disease and Down's syndrome.

Meflin defines mesenchymal stem cells and/or their early progenitors with multilineage differentiation capacity.

CD4 T cells are essential for the development of destructive thyroiditis induced by anti-PD-1 antibody in thyroglobulin-immunized mice.

Fibroblasts positive for meflin have anti-fibrotic property in pulmonary fibrosis.