Mercedes Gonzalez-Juarrero

In vivo IL-10 production reactivates chronic pulmonary tuberculosis in C57BL/6 mice.

Florid pulmonary inflammatory responses in mice vaccinated with Antigen-85 pulsed dendritic cells and challenged by aerosol with Mycobacterium tuberculosis.

Dynamics of macrophage cell populations during murine pulmonary tuberculosis.

NK cells respond to pulmonary infection with Mycobacterium tuberculosis, but play a minimal role in protection.

Stable T-cell population expressing an effector cell surface phenotype in the lungs of mice chronically infected with Mycobacterium tuberculosis.

Disruption of granulocyte macrophage-colony stimulating factor production in the lungs severely affects the ability of mice to control Mycobacterium tuberculosis infection.

Interleukin-10 production by lung macrophages in CBA xid mutant mice infected with Mycobacterium tuberculosis.

Factors associated with severe granulomatous pneumonia in Mycobacterium tuberculosis-infected mice vaccinated therapeutically with hsp65 DNA.

Foamy macrophages within lung granulomas of mice infected with Mycobacterium tuberculosis express molecules characteristic of dendritic cells and antiapoptotic markers of the TNF receptor-associated factor family.

Virulent clinical isolates of Mycobacterium tuberculosis grow rapidly and induce cellular necrosis but minimal apoptosis in murine macrophages.

Enhanced macrophage activity in granulomatous lesions of immune mice challenged with Mycobacterium tuberculosis.

Cross-reaction of anti-human CD monoclonal antibodies on guinea pig cells: a summary of the guinea pig section of the HLDA8 animal homologues data.

XCL1 (lymphotactin) chemokine produced by activated CD8 T cells during the chronic stage of infection with Mycobacterium tuberculosis negatively affects production of IFN-gamma by CD4 T cells and participates in granuloma stability.

Relative levels of M-CSF and GM-CSF influence the specific generation of macrophage populations during infection with Mycobacterium tuberculosis.

Phenotypic non-equivalence of murine (monocyte-) macrophage cells in biomaterial and inflammatory models.

Animal models of M. tuberculosis Infection.

Immune response to Mycobacterium tuberculosis and identification of molecular markers of disease.

Interleukin-10 promotes Mycobacterium tuberculosis disease progression in CBA/J mice.

Intrapulmonary delivery of XCL1-targeting small interfering RNA in mice chronically infected with Mycobacterium tuberculosis.

Lack of IL-10 alters inflammatory and immune responses during pulmonary Mycobacterium tuberculosis infection.

Localized immunosuppressive environment in the foreign body response to implanted biomaterials.

Differential polarization of alveolar macrophages and bone marrow-derived monocytes following chemically and pathogen-induced chronic lung inflammation.

Multiple M. tuberculosis phenotypes in mouse and guinea pig lung tissue revealed by a dual-staining approach.

Optimization of inhaled therapies for tuberculosis: the role of macrophages and dendritic cells.

Local pulmonary immunotherapy with siRNA targeting TGFβ1 enhances antimicrobial capacity in Mycobacterium tuberculosis infected mice.

Glycolytic and non-glycolytic functions of Mycobacterium tuberculosis fructose-1,6-bisphosphate aldolase, an essential enzyme produced by replicating and non-replicating bacilli.

Characterization of murine lung dendritic cells infected with Mycobacterium tuberculosis.

Temporal and spatial arrangement of lymphocytes within lung granulomas induced by aerosol infection with Mycobacterium tuberculosis.

Immunity to TB and targets for immunotherapy.

Mouse model for efficacy testing of antituberculosis agents via intrapulmonary delivery.

Exposure to a cutinase-like serine esterase triggers rapid lysis of multiple mycobacterial species.

Experimental aerosol Mycobacterium bovis model of infection in goats.

Correlates of immune protection following cutaneous immunization with an attenuated Burkholderia pseudomallei vaccine.

GM-CSF knockout mice for preclinical testing of agents with antimicrobial activity against Mycobacterium abscessus.

Polar lipids of Burkholderia pseudomallei induce different host immune responses.

Spectinamides: a new class of semisynthetic antituberculosis agents that overcome native drug efflux.

Microhemorrhage is an early event in the pulmonary fibrotic disease of PECAM-1 deficient FVB/n mice.

Long-term survival and virulence of Mycobacterium leprae in amoebal cysts.

Extended culture of macrophages from different sources and maturation results in a common M2 phenotype.

Presence of multiple lesion types with vastly different microenvironments in C3HeB/FeJ mice following aerosol infection with Mycobacterium tuberculosis.

Partial Saturation of Menaquinone in : Function and Essentiality of a Novel Reductase, MenJ.

Potential and development of inhaled RNAi therapeutics for the treatment of pulmonary tuberculosis.

Therapeutic Potential of the Mycobacterium tuberculosis Mycolic Acid Transporter, MmpL3.

Mycobacterium bovis hosted by free-living-amoebae permits their long-term persistence survival outside of host mammalian cells and remain capable of transmitting disease to mice.

The minipig as an animal model to study Mycobacterium tuberculosis infection and natural transmission.

Evaluation of shedding, tissue burdens, and humoral immune response in goats after experimental challenge with the virulent Brucella melitensis strain 16M and the reduced virulence vaccine strain Rev. 1.

Yersinia pestis Survival and Replication in Potential Ameba Reservoir.

Evidence of zoonotic leprosy in Pará, Brazilian Amazon, and risks associated with human contact or consumption of armadillos.

Cell mediated immune response in goats after experimental challenge with the virulent Brucella melitensis strain 16M and the reduced virulence strain Rev. 1.

Interactions of free-living amoebae with rice bacterial pathogens Xanthomonas oryzae pathovars oryzae and oryzicola.

Primary Lung Dendritic Cell Cultures to Assess Efficacy of Spectinamide-1599 Against Intracellular .

Optimization and Lead Selection of Benzothiazole Amide Analogs Toward a Novel Antimycobacterial Agent.

Host Directed Therapy for Chronic Tuberculosis via Intrapulmonary Delivery of Aerosolized Peptide Inhibitors Targeting the IL-10-STAT3 Pathway.

Comparative pharmacokinetics of spectinamide 1599 after subcutaneous and intrapulmonary aerosol administration in mice.

Direct Inhibition of MmpL3 by Novel Antitubercular Compounds.

Development and Characterization of a Dry Powder Formulation for Anti-Tuberculosis Drug Spectinamide 1599.

Sterilization of Mycobacterium tuberculosis infected samples using methanol preserves anti-tuberculosis drugs for subsequent pharmacological testing studies.

Minipigs as a neonatal animal model for tuberculosis vaccine efficacy testing.

Inhaled tigecycline is effective against Mycobacterium abscessus in vitro and in vivo.

Neonatal and infant immunity for tuberculosis vaccine development: importance of age-matched animal models.

Preclinical Evaluation of Inhalational Spectinamide-1599 Therapy against Tuberculosis.

Lipid nanoparticle formulation of niclosamide (nano NCM) effectively inhibits SARS-CoV-2 replication .

Unique Features of Biofilms Formed in Synthetic Cystic Fibrosis Medium.

Therapeutic efficacy of antimalarial drugs targeting DosRS signaling in .

Mycobacterium leprae Infection in a Wild Nine-Banded Armadillo, Nuevo León, Mexico.

Development of a Mucoadhesive Liquid Crystal System for the Administration of Rifampicin Applicable in Tuberculosis Therapy.

Microbiological profile, preclinical pharmacokinetics and efficacy of CRS0393, a novel antimycobacterial agent targeting MmpL3.

Mucosal exposure to non-tuberculous mycobacteria elicits B cell-mediated immunity against pulmonary tuberculosis.

Spray dried tigecycline dry powder aerosols for the treatment of Nontuberculous mycobacterial pulmonary infections.

Characterization of spectinamide 1599 efficacy against different mycobacterial phenotypes.

Intrapulmonary Treatment with Mycobacteriophage LysB Rapidly Reduces Mycobacterium abscessus Burden.

Development of a Minimalistic Physiologically Based Pharmacokinetic (mPBPK) Model for the Preclinical Development of Spectinamide Antibiotics.

Role of succinyl substituents in the mannose-capping of lipoarabinomannan and control of inflammation in Mycobacterium tuberculosis infection.

Impact of Methylthioxylose Substituents on the Biological Activities of Lipomannan and Lipoarabinomannan in .

Lipoarabinomannan modification as a source of phenotypic heterogeneity in host-adapted isolates.

Preclinical murine models for the testing of antimicrobials against Mycobacterium abscessus pulmonary infections: Current practices and recommendations.

Spectinamide MBX-4888A exhibits favorable lesion and tissue distribution and promotes treatment shortening in advanced murine models of tuberculosis.

A modified BPaL regimen for tuberculosis treatment replaces linezolid with inhaled spectinamides.

pulmonary infection and associated respiratory function in cystic fibrosis-like βENaC mice.

The DosR regulon of and adaptation to hypoxia.

Toward a Bactericidal Oral Drug Combination for the Treatment of Lung Disease.