Department of Surgery (RMH)
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PTEN catalysis of phospholipid dephosphorylation reaction follows a two-step mechanism in which the conserved aspartate-92 does not function as the general acid--mechanistic analysis of a familial Cowden disease-associated PTEN mutation.
Cellular signalling Jul, 2007 | Pubmed ID: 17324556
A novel non-catalytic mechanism employed by the C-terminal Src-homologous kinase to inhibit Src-family kinase activity.
The Journal of biological chemistry May, 2004 | Pubmed ID: 14985335
Expression, generation, and purification of unphosphorylated and phospho-Ser-380/Thr-382/Thr-383 form of recombinant PTEN phosphatase.
Protein expression and purification Oct, 2007 | Pubmed ID: 17562371
Transforming growth factor-beta (TGF-beta) and brain tumours.
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia Aug, 2008 | Pubmed ID: 18550374
Proteomics profiling of Madin-Darby canine kidney plasma membranes reveals Wnt-5a involvement during oncogenic H-Ras/TGF-beta-mediated epithelial-mesenchymal transition.
Molecular & cellular proteomics : MCP Feb, 2011 | Pubmed ID: 20511395
Unique biochemical properties of the protein tyrosine phosphatase activity of PTEN-demonstration of different active site structural requirements for phosphopeptide and phospholipid phosphatase activities of PTEN.
Biochimica et biophysica acta Sep, 2010 | Pubmed ID: 20685300
Specialized compartments of cardiac nuclei exhibit distinct proteomic anatomy.
Molecular & cellular proteomics : MCP Jan, 2011 | Pubmed ID: 20807835
Defining the substrate specificity determinants recognized by the active site of C-terminal Src kinase-homologous kinase (CHK) and identification of β-synuclein as a potential CHK physiological substrate.
Biochemistry Aug, 2011 | Pubmed ID: 21699177
New reagents for improved in vitro and in vivo examination of TGF-β signalling.
Growth factors (Chur, Switzerland) Oct, 2011 | Pubmed ID: 21913800
Regulation and function of protein kinases and phosphatases.
Enzyme research , 2011 | Pubmed ID: 22195276
Dynamin II function is required for EGF-mediated Stat3 activation but not Erk1/2 phosphorylation.
Growth factors (Chur, Switzerland) Aug, 2012 | Pubmed ID: 22574813
SMAD2, SMAD3 and SMAD4 mutations in colorectal cancer.
Cancer research Jan, 2013 | Pubmed ID: 23139211
TCPTP regulates SFK and STAT3 signaling and is lost in triple-negative breast cancers.
Molecular and cellular biology Feb, 2013 | Pubmed ID: 23166300
Oncogenic H-ras reprograms Madin-Darby canine kidney (MDCK) cell-derived exosomal proteins following epithelial-mesenchymal transition.
Molecular & cellular proteomics : MCP Aug, 2013 | Pubmed ID: 23645497
Betaglycan blocks metastatic behaviors in human granulosa cell tumors by suppressing NFκB-mediated induction of MMP2.
Cancer letters Nov, 2014 | Pubmed ID: 25128652
The immune suppressive function of transforming growth factor-β (TGF-β) in human diseases.
Growth factors (Chur, Switzerland) Apr, 2015 | Pubmed ID: 25714613
Emerging roles of exosomes during epithelial-mesenchymal transition and cancer progression.
Seminars in cell & developmental biology Apr, 2015 | Pubmed ID: 25721809
Single live cell TGF-β signalling imaging: breast cancer cell motility and migration is driven by sub-populations of cells with dynamic TGF-β-Smad3 activity.
Molecular cancer Feb, 2015 | Pubmed ID: 25744371
YBX1/YB-1 induces partial EMT and tumourigenicity through secretion of angiogenic factors into the extracellular microenvironment.
Oncotarget May, 2015 | Pubmed ID: 25980435
SPSB1, a Novel Negative Regulator of the Transforming Growth Factor-β Signaling Pathway Targeting the Type II Receptor.
The Journal of biological chemistry Jul, 2015 | Pubmed ID: 26032413
The C-terminal tail inhibitory phosphorylation sites of PTEN regulate its intrinsic catalytic activity and the kinetics of its binding to phosphatidylinositol-4,5-bisphosphate.
Archives of biochemistry and biophysics Dec, 2015 | Pubmed ID: 26471078
Oncogenic epithelial cell-derived exosomes containing Rac1 and PAK2 induce angiogenesis in recipient endothelial cells.
Oncotarget Apr, 2016 | Pubmed ID: 26919098
Extracellular vesicle isolation and characterization: toward clinical application.
The Journal of clinical investigation Apr, 2016 | Pubmed ID: 27035807
Transformed MDCK cells secrete elevated MMP1 that generates LAMA5 fragments promoting endothelial cell angiogenesis.
Scientific reports 06, 2016 | Pubmed ID: 27324842
Extracellular vesicles: their role in cancer biology and epithelial-mesenchymal transition.
The Biochemical journal 01, 2017 | Pubmed ID: 28008089
Mathematical model of TGF-βsignalling: feedback coupling is consistent with signal switching.
BMC systems biology 04, 2017 | Pubmed ID: 28407804
Csk-homologous kinase (Chk) is an efficient inhibitor of Src-family kinases but a poor catalyst of phosphorylation of their C-terminal regulatory tyrosine.
Cell communication and signaling : CCS 08, 2017 | Pubmed ID: 28784162
TGF-β and IL-6 family signalling crosstalk: an integrated model.
Growth factors (Chur, Switzerland) 06, 2017 | Pubmed ID: 28948853
Ras enhances TGF-β signaling by decreasing cellular protein levels of its type II receptor negative regulator SPSB1.
Cell communication and signaling : CCS Mar, 2018 | Pubmed ID: 29534718