Hong-Jian Zhu

PTEN catalysis of phospholipid dephosphorylation reaction follows a two-step mechanism in which the conserved aspartate-92 does not function as the general acid--mechanistic analysis of a familial Cowden disease-associated PTEN mutation.

A novel non-catalytic mechanism employed by the C-terminal Src-homologous kinase to inhibit Src-family kinase activity.

Expression, generation, and purification of unphosphorylated and phospho-Ser-380/Thr-382/Thr-383 form of recombinant PTEN phosphatase.

Transforming growth factor-beta (TGF-beta) and brain tumours.

Proteomics profiling of Madin-Darby canine kidney plasma membranes reveals Wnt-5a involvement during oncogenic H-Ras/TGF-beta-mediated epithelial-mesenchymal transition.

Unique biochemical properties of the protein tyrosine phosphatase activity of PTEN-demonstration of different active site structural requirements for phosphopeptide and phospholipid phosphatase activities of PTEN.

Specialized compartments of cardiac nuclei exhibit distinct proteomic anatomy.

Defining the substrate specificity determinants recognized by the active site of C-terminal Src kinase-homologous kinase (CHK) and identification of β-synuclein as a potential CHK physiological substrate.

New reagents for improved in vitro and in vivo examination of TGF-β signalling.

Regulation and function of protein kinases and phosphatases.

Dynamin II function is required for EGF-mediated Stat3 activation but not Erk1/2 phosphorylation.

SMAD2, SMAD3 and SMAD4 mutations in colorectal cancer.

TCPTP regulates SFK and STAT3 signaling and is lost in triple-negative breast cancers.

Oncogenic H-ras reprograms Madin-Darby canine kidney (MDCK) cell-derived exosomal proteins following epithelial-mesenchymal transition.

Betaglycan blocks metastatic behaviors in human granulosa cell tumors by suppressing NFκB-mediated induction of MMP2.

The immune suppressive function of transforming growth factor-β (TGF-β) in human diseases.

Emerging roles of exosomes during epithelial-mesenchymal transition and cancer progression.

Single live cell TGF-β signalling imaging: breast cancer cell motility and migration is driven by sub-populations of cells with dynamic TGF-β-Smad3 activity.

YBX1/YB-1 induces partial EMT and tumourigenicity through secretion of angiogenic factors into the extracellular microenvironment.

SPSB1, a Novel Negative Regulator of the Transforming Growth Factor-β Signaling Pathway Targeting the Type II Receptor.

The C-terminal tail inhibitory phosphorylation sites of PTEN regulate its intrinsic catalytic activity and the kinetics of its binding to phosphatidylinositol-4,5-bisphosphate.

Oncogenic epithelial cell-derived exosomes containing Rac1 and PAK2 induce angiogenesis in recipient endothelial cells.

Extracellular vesicle isolation and characterization: toward clinical application.

Transformed MDCK cells secrete elevated MMP1 that generates LAMA5 fragments promoting endothelial cell angiogenesis.

Extracellular vesicles: their role in cancer biology and epithelial-mesenchymal transition.

Mathematical model of TGF-βsignalling: feedback coupling is consistent with signal switching.

Csk-homologous kinase (Chk) is an efficient inhibitor of Src-family kinases but a poor catalyst of phosphorylation of their C-terminal regulatory tyrosine.

TGF-β and IL-6 family signalling crosstalk: an integrated model.

Ras enhances TGF-β signaling by decreasing cellular protein levels of its type II receptor negative regulator SPSB1.