S'identifier

Francesca Tonelli

MRC Protein Phosphorylation and Ubiquitylation Unit,
School of Life Sciences,
MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences

University of Dundee

BIOGRAPHY

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PUBLICATIONS

The roles of sphingosine kinase 1 and 2 in regulating the metabolome and survival of prostate cancer cells.

Biomolecules Jun, 2013 | Pubmed ID: 24970170

Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases.

eLife Jan, 2016 | Pubmed ID: 26824392

Phos-tag analysis of Rab10 phosphorylation by LRRK2: a powerful assay for assessing kinase function and inhibitors.

The Biochemical journal Sep, 2016 | Pubmed ID: 27474410

Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis.

eLife 11, 2017 | Pubmed ID: 29125462

Development of phospho-specific Rab protein antibodies to monitor activity of the LRRK2 Parkinson's disease kinase.

The Biochemical journal 01, 2018 | Pubmed ID: 29127256

Rab29 activation of the Parkinson's disease-associated LRRK2 kinase.

The EMBO journal 01, 2018 | Pubmed ID: 29212815

The Parkinson's disease VPS35[D620N] mutation enhances LRRK2-mediated Rab protein phosphorylation in mouse and human.

The Biochemical journal 06, 2018 | Pubmed ID: 29743203

A pathway for Parkinson's Disease LRRK2 kinase to block primary cilia and Sonic hedgehog signaling in the brain.

eLife 11, 2018 | Pubmed ID: 30398148

A chemical-genetics approach to study the role of atypical Protein Kinase C in .

Development (Cambridge, England) 01, 2019 | Pubmed ID: 30635282

PPM1H phosphatase counteracts LRRK2 signaling by selectively dephosphorylating Rab proteins.

eLife 10, 2019 | Pubmed ID: 31663853

INSTITUTIONS

University of Dundee

JOVE ARTICLES

Human Peripheral Blood Neutrophil Isolation for Interrogating the Parkinson's Associated LRRK2 Kinase Pathway by Assessing Rab10 Phosphorylation

Ying Fan^*,1,

Francesca Tonelli^*,1,

Shalini Padmanabhan²,

Marco A.S. Baptista²,

Lindsey Riley²,

Danielle Smith³,

Connie Marras⁴,

Andrew Howden⁵,

Dario R. Alessi¹,

Esther Sammler^1,6

¹MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee,

², The Michael J. Fox Foundation for Parkinson's Research,

³Department of Medical and Molecular Genetics, Indiana University School of Medicine,

⁴Morton and Gloria Shulman Movement Disorders Centre and the Edmond J. Safra Program in Parkinson's Disease, Toronto Western Hospital, University of Toronto,

⁵Division of Cell Signalling and Immunology, School of Life Sciences, University of Dundee,

⁶Division of Molecular and Clinical Medicine, School of Medicine, Ninewells Hospital and Medical School, University of Dundee

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Francesca Tonelli

.css-o250i3{font-size:18px;font-family:Open Sans,sans-serif;line-height:21.6px;}MRC Protein Phosphorylation and Ubiquitylation Unit,School of Life Sciences,MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences

University of Dundee

Human Peripheral Blood Neutrophil Isolation for Interrogating the Parkinson's Associated LRRK2 Kinase Pathway by Assessing Rab10 Phosphorylation

MRC Protein Phosphorylation and Ubiquitylation Unit,
School of Life Sciences,
MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences