Lineberger Comprehensive Cancer Center
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Inactivation of the antiapoptotic phosphatidylinositol 3-kinase-Akt pathway by the combined treatment of taxol and mitogen-activated protein kinase kinase inhibition.
Clinical cancer research : an official journal of the American Association for Cancer Research Jul, 2002 | Pubmed ID: 12114408
Human epidermal receptor-2 expression in prostate cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research Mar, 2003 | Pubmed ID: 12631612
The EGF receptor family--multiple roles in proliferation, differentiation, and neoplasia with an emphasis on HER4.
Transactions of the American Clinical and Climatological Association , 2003 | Pubmed ID: 12813928
Dependence of peroxisome proliferator-activated receptor ligand-induced mitogen-activated protein kinase signaling on epidermal growth factor receptor transactivation.
The Journal of biological chemistry Nov, 2003 | Pubmed ID: 12966092
Transactivation of the EGF receptor: is the PDGF receptor an unexpected accomplice?
Molecular interventions Jul, 2002 | Pubmed ID: 14993390
Dendritic cells can be rapidly expanded ex vivo and safely administered in patients with metastatic breast cancer.
Cancer immunology, immunotherapy : CII Sep, 2004 | Pubmed ID: 15185007
The C-mer gene is induced by Epstein-Barr virus immediate-early protein BRLF1.
Journal of virology Nov, 2004 | Pubmed ID: 15479819
Role of Gas6 receptors in platelet signaling during thrombus stabilization and implications for antithrombotic therapy.
The Journal of clinical investigation Feb, 2005 | Pubmed ID: 15650770
Activated tyrosine kinase Ack1 promotes prostate tumorigenesis: role of Ack1 in polyubiquitination of tumor suppressor Wwox.
Cancer research Nov, 2005 | Pubmed ID: 16288044
The intracellular domain of ErbB4 induces differentiation of mammary epithelial cells.
Molecular biology of the cell Sep, 2006 | Pubmed ID: 16837552
Apoptotic cells induce Mer tyrosine kinase-dependent blockade of NF-kappaB activation in dendritic cells.
Blood Jan, 2007 | Pubmed ID: 17008547
Activated Cdc42-associated kinase Ack1 promotes prostate cancer progression via androgen receptor tyrosine phosphorylation.
Proceedings of the National Academy of Sciences of the United States of America May, 2007 | Pubmed ID: 17494760
The HER4 cytoplasmic domain, but not its C terminus, inhibits mammary cell proliferation.
Molecular endocrinology (Baltimore, Md.) Aug, 2007 | Pubmed ID: 17505063
Capacitative calcium entry contributes to the differential transactivation of the epidermal growth factor receptor in response to thiazolidinediones.
Molecular pharmacology Nov, 2007 | Pubmed ID: 17686966
Research for North Carolina: The University Cancer Research Fund.
North Carolina medical journal Jul-Aug, 2008 | Pubmed ID: 18828322
The E3 ubiquitin ligase WWP1 selectively targets HER4 and its proteolytically derived signaling isoforms for degradation.
Molecular and cellular biology Feb, 2009 | Pubmed ID: 19047365
ErbB4 splice variants Cyt1 and Cyt2 differ by 16 amino acids and exert opposing effects on the mammary epithelium in vivo.
Molecular and cellular biology Sep, 2009 | Pubmed ID: 19596786
TAM receptors are dispensable in the phagocytosis and killing of bacteria.
Cellular immunology , 2009 | Pubmed ID: 19625016
A novel role for c-Src and STAT3 in apoptotic cell-mediated MerTK-dependent immunoregulation of dendritic cells.
Blood Oct, 2009 | Pubmed ID: 19667404
Dasatinib inhibits site-specific tyrosine phosphorylation of androgen receptor by Ack1 and Src kinases.
Oncogene Jun, 2010 | Pubmed ID: 20383201
Increased hematopoietic cells in the mertk-/- mouse peritoneal cavity: a result of augmented migration.
Journal of immunology (Baltimore, Md. : 1950) Jun, 2010 | Pubmed ID: 20483720
Discovery of Novel Small Molecule Mer Kinase Inhibitors for the Treatment of Pediatric Acute Lymphoblastic Leukemia.
ACS medicinal chemistry letters Feb, 2012 | Pubmed ID: 22662287
MERTK receptor tyrosine kinase is a therapeutic target in melanoma.
The Journal of clinical investigation May, 2013 | Pubmed ID: 23585477
UNC1062, a new and potent Mer inhibitor.
European journal of medicinal chemistry Jul, 2013 | Pubmed ID: 23693152
Molecular Pathways: MERTK Signaling in Cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research Aug, 2013 | Pubmed ID: 23833304
UNC569, a novel small molecule Mer inhibitor with efficacy against acute lymphoblastic leukemia in vitro and in vivo.
Molecular cancer therapeutics Aug, 2013 | Pubmed ID: 23997116
Pseudo-cyclization through intramolecular hydrogen bond enables discovery of pyridine substituted pyrimidines as new Mer kinase inhibitors.
Journal of medicinal chemistry Dec, 2013 | Pubmed ID: 24195762
Discovery of Mer specific tyrosine kinase inhibitors for the treatment and prevention of thrombosis.
Journal of medicinal chemistry Dec, 2013 | Pubmed ID: 24219778
UNC2025, a potent and orally bioavailable MER/FLT3 dual inhibitor.
Journal of medicinal chemistry Aug, 2014 | Pubmed ID: 25068800
Mer590, a novel monoclonal antibody targeting MER receptor tyrosine kinase, decreases colony formation and increases chemosensitivity in non-small cell lung cancer.
Oncotarget Nov, 2014 | Pubmed ID: 25372020
Mutation of androgen receptor N-terminal phosphorylation site Tyr-267 leads to inhibition of nuclear translocation and DNA binding.
PloS one , 2015 | Pubmed ID: 25950519
Combined Targeted DNA Sequencing in Non-Small Cell Lung Cancer (NSCLC) Using UNCseq and NGScopy, and RNA Sequencing Using UNCqeR for the Detection of Genetic Aberrations in NSCLC.
PloS one , 2015 | Pubmed ID: 26076459
Small Molecule Inhibition of MERTK Is Efficacious in Non-Small Cell Lung Cancer Models Independent of Driver Oncogene Status.
Molecular cancer therapeutics Sep, 2015 | Pubmed ID: 26162689
Germline Analysis from Tumor-Germline Sequencing Dyads to Identify Clinically Actionable Secondary Findings.
Clinical cancer research : an official journal of the American Association for Cancer Research Aug, 2016 | Pubmed ID: 27083775
The MERTK/FLT3 inhibitor MRX-2843 overcomes resistance-conferring FLT3 mutations in acute myeloid leukemia.
JCI insight Mar, 2016 | Pubmed ID: 27158668
MERTK Inhibition Induces Polyploidy and Promotes Cell Death and Cellular Senescence in Glioblastoma Multiforme.
PloS one , 2016 | Pubmed ID: 27783662
Design and Synthesis of Novel Macrocyclic Mer Tyrosine Kinase Inhibitors.
ACS medicinal chemistry letters Dec, 2016 | Pubmed ID: 27994735
Discovery of Macrocyclic Pyrimidines as MerTK-Specific Inhibitors.
ChemMedChem 02, 2017 | Pubmed ID: 28032464
Racial Differences in PAM50 Subtypes in the Carolina Breast Cancer Study.
Journal of the National Cancer Institute 02, 2018 | Pubmed ID: 28859290
The small-molecule MERTK inhibitor UNC2025 decreases platelet activation and prevents thrombosis.
Journal of thrombosis and haemostasis : JTH 02, 2018 | Pubmed ID: 29045015
Enhancing Next-Generation Sequencing-Guided Cancer Care Through Cognitive Computing.
The oncologist 02, 2018 | Pubmed ID: 29158372
Tumor-secreted Pros1 inhibits macrophage M1 polarization to reduce antitumor immune response.
The Journal of clinical investigation 06, 2018 | Pubmed ID: 29708510
Factor XIIIA-expressing inflammatory monocytes promote lung squamous cancer through fibrin cross-linking.
Nature communications 05, 2018 | Pubmed ID: 29777108
Identification of Clonal Hematopoiesis Mutations in Solid Tumor Patients Undergoing Unpaired Next-Generation Sequencing Assays.
Clinical cancer research : an official journal of the American Association for Cancer Research 12, 2018 | Pubmed ID: 29866652
MERTK Mediates Intrinsic and Adaptive Resistance to AXL-targeting Agents.
Molecular cancer therapeutics 11, 2018 | Pubmed ID: 30093568
MERTK Promotes Resistance to Irreversible EGFR Tyrosine Kinase Inhibitors in Non-small Cell Lung Cancers Expressing Wild-type Family Members.
Clinical cancer research : an official journal of the American Association for Cancer Research 12, 2018 | Pubmed ID: 30194074
ZFX Mediates Non-canonical Oncogenic Functions of the Androgen Receptor Splice Variant 7 in Castrate-Resistant Prostate Cancer.
Molecular cell 10, 2018 | Pubmed ID: 30270106
Inhibition of MERTK Promotes Suppression of Tumor Growth in BRAF Mutant and BRAF Wild-Type Melanoma.
Molecular cancer therapeutics 02, 2019 | Pubmed ID: 30482852
The Prognostic Significance of Low-Frequency Somatic Mutations in Metastatic Cutaneous Melanoma.
Frontiers in oncology , 2018 | Pubmed ID: 30662871
SGC-GAK-1: A Chemical Probe for Cyclin G Associated Kinase (GAK).
Journal of medicinal chemistry Mar, 2019 | Pubmed ID: 30768268
MERTK mediated novel site Akt phosphorylation alleviates SAV1 suppression.
Nature communications 04, 2019 | Pubmed ID: 30944303
Beyond growth signaling: apoptotic sensor MERTK activates AKT by a novel mechanism.
Molecular & cellular oncology , 2019 | Pubmed ID: 31211243
Kinome profiling of non-Hodgkin lymphoma identifies Tyro3 as a therapeutic target in primary effusion lymphoma.
Proceedings of the National Academy of Sciences of the United States of America Aug, 2019 | Pubmed ID: 31346082
TAM Family Receptor Kinase Inhibition Reverses MDSC-Mediated Suppression and Augments Anti-PD-1 Therapy in Melanoma.
Cancer immunology research Oct, 2019 | Pubmed ID: 31451482
Data-Driven Construction of Antitumor Agents with Controlled Polypharmacology.
Journal of the American Chemical Society Oct, 2019 | Pubmed ID: 31497954
Bimodal age distribution at diagnosis in breast cancer persists across molecular and genomic classifications.
Breast cancer research and treatment Sep, 2019 | Pubmed ID: 31535320