Results: The Effects of Tumor-secreted Paracrine Ligands on Macrophage Activation
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Conclusion
Transcription
This Transwell co-culture method is used to study paracrine signaling used by tumor cells to suppress the immune response. This method can be used to discover novel secreted ligands, as well as the mechanistic underpinnings of their immune suppres
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Here, we present a method using permeable membrane supports to facilitate the study of non-contact paracrine signaling used by tumor cells to suppress the immune response. The system is amenable to studying the role of tumor-secreted factors in dampening macrophage activation.