Owen P. McGuinness

Physiological consequences of phasic insulin release in the normal animal.

Impact of intraportal N(omega)-nitro-L-arginine infusion on hepatic glucose metabolism in total parenteral nutrition-adapted dogs: interaction with infection.

Impact of chronic fructose infusion on hepatic metabolism during TPN administration.

Infection impairs insulin-dependent hepatic glucose uptake during total parenteral nutrition.

Effects of fructose on hepatic glucose metabolism.

Impact of infection on glucose-dependent liver glucose uptake during TPN: interaction with insulin.

Prevention of obesity and insulin resistance in mice lacking plasminogen activator inhibitor 1.

Microfluidic glucose stimulation reveals limited coordination of intracellular Ca2+ activity oscillations in pancreatic islets.

Time course of the hepatic adaptation to TPN: interaction with glycogen depletion.

Control of muscle glucose uptake: test of the rate-limiting step paradigm in conscious, unrestrained mice.

Impact of continuous and pulsatile insulin delivery on net hepatic glucose uptake.

Route-dependent effect of nutritional support on liver glucose uptake.

Defective glucose homeostasis during infection.

Suppression of aging in mice by the hormone Klotho.

Insulin secretion in the conscious mouse is biphasic and pulsatile.

Overexpression of the insulin receptor inhibitor PC-1/ENPP1 induces insulin resistance and hyperglycemia.

Individual mice can be distinguished by the period of their islet calcium oscillations: is there an intrinsic islet period that is imprinted in vivo?

Considerations in the design of hyperinsulinemic-euglycemic clamps in the conscious mouse.

Glucocorticoid-deficient corticotropin-releasing hormone knockout mice maintain glucose requirements but not autonomic responses during repeated hypoglycemia.

Counterregulatory deficits occur within 24 h of a single hypoglycemic episode in conscious, unrestrained, chronically cannulated mice.

Impact of portal glucose delivery on glucose metabolism in conscious, unrestrained mice.

Deletion of the gene encoding the ubiquitously expressed glucose-6-phosphatase catalytic subunit-related protein (UGRP)/glucose-6-phosphatase catalytic subunit-beta results in lowered plasma cholesterol and elevated glucagon.

Monoclonal antibody antagonists of hypothalamic FGFR1 cause potent but reversible hypophagia and weight loss in rodents and monkeys.

Glucagon chronically impairs hepatic and muscle glucose disposal.

Point-counterpoint: Interleukin-6 does/does not have a beneficial role in insulin sensitivity and glucose homeostasis.

Macrophage TNF-alpha contributes to insulin resistance and hepatic steatosis in diet-induced obesity.

Glucagon-mediated impairments in hepatic and peripheral tissue nutrient disposal are not aggravated by increased lipid availability.

Insulin signaling in alpha cells modulates glucagon secretion in vivo.

Inactivation of NF-kappaB p50 leads to insulin sensitization in liver through post-translational inhibition of p70S6K.

Deletion of the mouse Slc30a8 gene encoding zinc transporter-8 results in impaired insulin secretion.

Skeletal muscle AMP-activated protein kinase is essential for the metabolic response to exercise in vivo.

NIH experiment in centralized mouse phenotyping: the Vanderbilt experience and recommendations for evaluating glucose homeostasis in the mouse.

Lost in translation.

Metabolic response to endotoxin in vivo in the conscious mouse: role of interleukin-6.

Circadian clock gene Bmal1 is not essential; functional replacement with its paralog, Bmal2.

Impaired glucose tolerance and predisposition to the fasted state in liver glycogen synthase knock-out mice.

Advantages of dynamic "closed loop" stable isotope flux phenotyping over static "open loop" clamps in detecting silent genetic and dietary phenotypes.

Standard operating procedures for describing and performing metabolic tests of glucose homeostasis in mice.

Continuous low-dose fructose infusion does not reverse glucagon-mediated decrease in hepatic glucose utilization.

Assessment of different bariatric surgeries in the treatment of obesity and insulin resistance in mice.

Ablation of ghrelin receptor reduces adiposity and improves insulin sensitivity during aging by regulating fat metabolism in white and brown adipose tissues.

Disassociation of Muscle Insulin Signaling and Insulin-Stimulated Glucose Uptake during Endotoxemia.

Adropin deficiency is associated with increased adiposity and insulin resistance.