Department of Molecular Physiology and Biophysics,
Vanderbilt Mouse Metabolic Phenotyping Center
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Physiological consequences of phasic insulin release in the normal animal.
Diabetes Feb, 2002 | Pubmed ID: 11815467
Impact of intraportal N(omega)-nitro-L-arginine infusion on hepatic glucose metabolism in total parenteral nutrition-adapted dogs: interaction with infection.
Metabolism: clinical and experimental Mar, 2002 | Pubmed ID: 11887160
Impact of chronic fructose infusion on hepatic metabolism during TPN administration.
American journal of physiology. Endocrinology and metabolism Dec, 2002 | Pubmed ID: 12424103
Infection impairs insulin-dependent hepatic glucose uptake during total parenteral nutrition.
American journal of physiology. Endocrinology and metabolism Mar, 2003 | Pubmed ID: 12441309
Effects of fructose on hepatic glucose metabolism.
Current opinion in clinical nutrition and metabolic care Jul, 2003 | Pubmed ID: 12806219
Impact of infection on glucose-dependent liver glucose uptake during TPN: interaction with insulin.
American journal of physiology. Endocrinology and metabolism Feb, 2004 | Pubmed ID: 14532169
Prevention of obesity and insulin resistance in mice lacking plasminogen activator inhibitor 1.
Diabetes Feb, 2004 | Pubmed ID: 14747283
Microfluidic glucose stimulation reveals limited coordination of intracellular Ca2+ activity oscillations in pancreatic islets.
Proceedings of the National Academy of Sciences of the United States of America Aug, 2004 | Pubmed ID: 15317941
Time course of the hepatic adaptation to TPN: interaction with glycogen depletion.
American journal of physiology. Endocrinology and metabolism Jan, 2005 | Pubmed ID: 15339746
Control of muscle glucose uptake: test of the rate-limiting step paradigm in conscious, unrestrained mice.
The Journal of physiology Feb, 2005 | Pubmed ID: 15576451
Impact of continuous and pulsatile insulin delivery on net hepatic glucose uptake.
American journal of physiology. Endocrinology and metabolism Aug, 2005 | Pubmed ID: 15755768
Route-dependent effect of nutritional support on liver glucose uptake.
American journal of physiology. Regulatory, integrative and comparative physiology Nov, 2005 | Pubmed ID: 15994371
Defective glucose homeostasis during infection.
Annual review of nutrition , 2005 | Pubmed ID: 16011457
Suppression of aging in mice by the hormone Klotho.
Science (New York, N.Y.) Sep, 2005 | Pubmed ID: 16123266
Insulin secretion in the conscious mouse is biphasic and pulsatile.
American journal of physiology. Endocrinology and metabolism Mar, 2006 | Pubmed ID: 16249252
Overexpression of the insulin receptor inhibitor PC-1/ENPP1 induces insulin resistance and hyperglycemia.
American journal of physiology. Endocrinology and metabolism Apr, 2006 | Pubmed ID: 16278247
Individual mice can be distinguished by the period of their islet calcium oscillations: is there an intrinsic islet period that is imprinted in vivo?
Diabetes Dec, 2005 | Pubmed ID: 16306370
Considerations in the design of hyperinsulinemic-euglycemic clamps in the conscious mouse.
Diabetes Feb, 2006 | Pubmed ID: 16443772
Glucocorticoid-deficient corticotropin-releasing hormone knockout mice maintain glucose requirements but not autonomic responses during repeated hypoglycemia.
American journal of physiology. Endocrinology and metabolism Jul, 2006 | Pubmed ID: 16449297
Counterregulatory deficits occur within 24 h of a single hypoglycemic episode in conscious, unrestrained, chronically cannulated mice.
American journal of physiology. Endocrinology and metabolism Apr, 2006 | Pubmed ID: 16533951
Impact of portal glucose delivery on glucose metabolism in conscious, unrestrained mice.
American journal of physiology. Endocrinology and metabolism Dec, 2006 | Pubmed ID: 16822956
Deletion of the gene encoding the ubiquitously expressed glucose-6-phosphatase catalytic subunit-related protein (UGRP)/glucose-6-phosphatase catalytic subunit-beta results in lowered plasma cholesterol and elevated glucagon.
The Journal of biological chemistry Dec, 2006 | Pubmed ID: 17023421
Monoclonal antibody antagonists of hypothalamic FGFR1 cause potent but reversible hypophagia and weight loss in rodents and monkeys.
American journal of physiology. Endocrinology and metabolism Mar, 2007 | Pubmed ID: 17132826
Glucagon chronically impairs hepatic and muscle glucose disposal.
American journal of physiology. Endocrinology and metabolism Mar, 2007 | Pubmed ID: 17132827
Point-counterpoint: Interleukin-6 does/does not have a beneficial role in insulin sensitivity and glucose homeostasis.
Journal of applied physiology (Bethesda, Md. : 1985) Feb, 2007 | Pubmed ID: 17323468
Macrophage TNF-alpha contributes to insulin resistance and hepatic steatosis in diet-induced obesity.
American journal of physiology. Endocrinology and metabolism Sep, 2007 | Pubmed ID: 17578885
Glucagon-mediated impairments in hepatic and peripheral tissue nutrient disposal are not aggravated by increased lipid availability.
American journal of physiology. Endocrinology and metabolism May, 2009 | Pubmed ID: 19208853
Insulin signaling in alpha cells modulates glucagon secretion in vivo.
Cell metabolism Apr, 2009 | Pubmed ID: 19356716
Inactivation of NF-kappaB p50 leads to insulin sensitization in liver through post-translational inhibition of p70S6K.
The Journal of biological chemistry Jul, 2009 | Pubmed ID: 19433583
Deletion of the mouse Slc30a8 gene encoding zinc transporter-8 results in impaired insulin secretion.
The Biochemical journal Aug, 2009 | Pubmed ID: 19450229
Skeletal muscle AMP-activated protein kinase is essential for the metabolic response to exercise in vivo.
The Journal of biological chemistry Sep, 2009 | Pubmed ID: 19525228
NIH experiment in centralized mouse phenotyping: the Vanderbilt experience and recommendations for evaluating glucose homeostasis in the mouse.
American journal of physiology. Endocrinology and metabolism Oct, 2009 | Pubmed ID: 19638507
Lost in translation.
Diabetes Sep, 2009 | Pubmed ID: 19720822
Metabolic response to endotoxin in vivo in the conscious mouse: role of interleukin-6.
Metabolism: clinical and experimental Jan, 2011 | Pubmed ID: 20102773
Circadian clock gene Bmal1 is not essential; functional replacement with its paralog, Bmal2.
Current biology : CB Feb, 2010 | Pubmed ID: 20153195
Impaired glucose tolerance and predisposition to the fasted state in liver glycogen synthase knock-out mice.
The Journal of biological chemistry Apr, 2010 | Pubmed ID: 20178984
Advantages of dynamic "closed loop" stable isotope flux phenotyping over static "open loop" clamps in detecting silent genetic and dietary phenotypes.
Metabolomics : Official journal of the Metabolomic Society Jun, 2010 | Pubmed ID: 20445758
Standard operating procedures for describing and performing metabolic tests of glucose homeostasis in mice.
Disease models & mechanisms Sep-Oct, 2010 | Pubmed ID: 20713647
Continuous low-dose fructose infusion does not reverse glucagon-mediated decrease in hepatic glucose utilization.
Metabolism: clinical and experimental Jun, 2011 | Pubmed ID: 20940071
Assessment of different bariatric surgeries in the treatment of obesity and insulin resistance in mice.
Annals of surgery Jul, 2011 | Pubmed ID: 21522012
Ablation of ghrelin receptor reduces adiposity and improves insulin sensitivity during aging by regulating fat metabolism in white and brown adipose tissues.
Aging cell Dec, 2011 | Pubmed ID: 21895961
Disassociation of Muscle Insulin Signaling and Insulin-Stimulated Glucose Uptake during Endotoxemia.
PloS one , 2012 | Pubmed ID: 22276152
Adropin deficiency is associated with increased adiposity and insulin resistance.
Obesity (Silver Spring, Md.) Feb, 2012 | Pubmed ID: 22318315
Julio E. Ayala1,
Deanna P. Bracy2,3,
Carlo Malabanan3,
Freyja D. James2,3,
Tasneem Ansari3,
Patrick T. Fueger4,
Owen P. McGuinness2,3,
David H. Wasserman2,3
1Diabetes and Obesity Research Center, Sanford-Burnham Medical Research Institute at Lake Nona,
2Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine,
3Vanderbilt Mouse Metabolic Phenotyping Center, Vanderbilt University School of Medicine,
4Department of Pediatrics and Cellular and Integrative Physiology, Indiana University School of Medicine
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