Institute of Molecular Cardiology,
Department of Medicine,
Institute of Molecular Cardiology, Department of Medicine
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Nitric oxide donors induce late preconditioning against myocardial stunning and infarction in conscious rabbits via an antioxidant-sensitive mechanism.
Circulation research Jul, 1998 | Pubmed ID: 9670920
Demonstration of an early and a late phase of ischemic preconditioning in mice.
The American journal of physiology 10, 1998 | Pubmed ID: 9746488
The late phase of ischemic preconditioning is abrogated by targeted disruption of the inducible NO synthase gene.
Proceedings of the National Academy of Sciences of the United States of America Sep, 1999 | Pubmed ID: 10500207
Cyclooxygenase-2 mediates the cardioprotective effects of the late phase of ischemic preconditioning in conscious rabbits.
Proceedings of the National Academy of Sciences of the United States of America Aug, 2000 | Pubmed ID: 10963682
Evidence for an essential role of cyclooxygenase-2 as a mediator of the late phase of ischemic preconditioning in mice.
Basic research in cardiology Dec, 2000 | Pubmed ID: 11192369
Gene therapy with extracellular superoxide dismutase protects conscious rabbits against myocardial infarction.
Circulation Apr, 2001 | Pubmed ID: 11294809
Oxidant species trigger late preconditioning against myocardial stunning in conscious rabbits.
American journal of physiology. Heart and circulatory physiology Jan, 2002 | Pubmed ID: 11748073
Nitric oxide (NO) induces nitration of protein kinase Cepsilon (PKCepsilon ), facilitating PKCepsilon translocation via enhanced PKCepsilon -RACK2 interactions: a novel mechanism of no-triggered activation of PKCepsilon.
The Journal of biological chemistry Apr, 2002 | Pubmed ID: 11839754
Formation of protein kinase C(epsilon)-Lck signaling modules confers cardioprotection.
The Journal of clinical investigation Feb, 2002 | Pubmed ID: 11854322
Inducible nitric oxide synthase modulates cyclooxygenase-2 activity in the heart of conscious rabbits during the late phase of ischemic preconditioning.
Circulation research Mar, 2002 | Pubmed ID: 11909825
Role of cyclic guanosine monophosphate in late preconditioning in conscious rabbits.
Circulation Jun, 2002 | Pubmed ID: 12082001
Role of Src protein tyrosine kinases in late preconditioning against myocardial infarction.
American journal of physiology. Heart and circulatory physiology Aug, 2002 | Pubmed ID: 12124200
Discovery of a new function of cyclooxygenase (COX)-2: COX-2 is a cardioprotective protein that alleviates ischemia/reperfusion injury and mediates the late phase of preconditioning.
Cardiovascular research Aug, 2002 | Pubmed ID: 12160947
Aldose reductase is an obligatory mediator of the late phase of ischemic preconditioning.
Circulation research Aug, 2002 | Pubmed ID: 12169650
Delta-opioid receptor-induced late preconditioning is mediated by cyclooxygenase-2 in conscious rabbits.
American journal of physiology. Heart and circulatory physiology Nov, 2002 | Pubmed ID: 12384473
Protein tyrosine kinase signaling is necessary for NO donor-induced late preconditioning against myocardial stunning.
American journal of physiology. Heart and circulatory physiology Apr, 2003 | Pubmed ID: 12531734
Effect of aspirin on late preconditioning against myocardial stunning in conscious rabbits.
Journal of the American College of Cardiology Apr, 2003 | Pubmed ID: 12679220
Nonelectrocardiographic evidence that both ischemic preconditioning and adenosine preconditioning exist in humans.
Journal of the American College of Cardiology Aug, 2003 | Pubmed ID: 12906969
Nicorandil induces late preconditioning against myocardial infarction in conscious rabbits.
American journal of physiology. Heart and circulatory physiology Apr, 2004 | Pubmed ID: 14684373
Cardioprotection during the final stage of the late phase of ischemic preconditioning is mediated by neuronal NO synthase in concert with cyclooxygenase-2.
Circulation research Jul, 2004 | Pubmed ID: 15166094
Hypercholesterolemia blunts NO donor-induced late preconditioning against myocardial infarction in conscious rabbits.
Basic research in cardiology Nov, 2004 | Pubmed ID: 15372283
Delayed adaptation of the heart to stress: late preconditioning.
Stroke Nov, 2004 | Pubmed ID: 15459441
Cardiac stem cells delivered intravascularly traverse the vessel barrier, regenerate infarcted myocardium, and improve cardiac function.
Proceedings of the National Academy of Sciences of the United States of America Mar, 2005 | Pubmed ID: 15734798
Delayed preconditioning-mimetic actions of nitroglycerin in patients undergoing exercise tolerance tests.
Circulation May, 2005 | Pubmed ID: 15897341
Hypercholesterolemia abrogates late preconditioning via a tetrahydrobiopterin-dependent mechanism in conscious rabbits.
Circulation Oct, 2005 | Pubmed ID: 16186416
Redox activation of aldose reductase in the ischemic heart.
The Journal of biological chemistry Jun, 2006 | Pubmed ID: 16567803
Cardioprotection by postconditioning in conscious rats is limited to coronary occlusions <45 min.
American journal of physiology. Heart and circulatory physiology Nov, 2006 | Pubmed ID: 16815986
Effects of anesthesia on echocardiographic assessment of left ventricular structure and function in rats.
Basic research in cardiology Jan, 2007 | Pubmed ID: 17006633
Pretreatment with intracoronary enalaprilat protects human myocardium during percutaneous coronary angioplasty.
Journal of the American College of Cardiology Apr, 2007 | Pubmed ID: 17433950
The late phase of preconditioning and its natural clinical application--gene therapy.
Heart failure reviews Dec, 2007 | Pubmed ID: 17541820
The cardioprotection of the late phase of ischemic preconditioning is enhanced by postconditioning via a COX-2-mediated mechanism in conscious rats.
American journal of physiology. Heart and circulatory physiology Oct, 2007 | Pubmed ID: 17704286
Role of nitric oxide in regulating aldose reductase activation in the ischemic heart.
The Journal of biological chemistry Apr, 2008 | Pubmed ID: 18223294
Noncanonical Wnt11 signaling is sufficient to induce cardiomyogenic differentiation in unfractionated bone marrow mononuclear cells.
Circulation Apr, 2008 | Pubmed ID: 18427129
The role of TNF-alpha receptors p55 and p75 in acute myocardial ischemia/reperfusion injury and late preconditioning.
Journal of molecular and cellular cardiology Dec, 2008 | Pubmed ID: 18824172
Intracoronary administration of cardiac progenitor cells alleviates left ventricular dysfunction in rats with a 30-day-old infarction.
Circulation Jan, 2010 | Pubmed ID: 20048209
Cardiac progenitor cells and bone marrow-derived very small embryonic-like stem cells for cardiac repair after myocardial infarction.
Circulation journal : official journal of the Japanese Circulation Society Mar, 2010 | Pubmed ID: 20081317
Transplantation of expanded bone marrow-derived very small embryonic-like stem cells (VSEL-SCs) improves left ventricular function and remodelling after myocardial infarction.
Journal of cellular and molecular medicine Jun, 2011 | Pubmed ID: 20629987
Atorvastatin therapy during the peri-infarct period attenuates left ventricular dysfunction and remodeling after myocardial infarction.
PloS one , 2011 | Pubmed ID: 21980426
The heme oxygenase 1 inducer (CoPP) protects human cardiac stem cells against apoptosis through activation of the extracellular signal-regulated kinase (ERK)/NRF2 signaling pathway and cytokine release.
The Journal of biological chemistry Sep, 2012 | Pubmed ID: 22879597
Intracoronary delivery of autologous cardiac stem cells improves cardiac function in a porcine model of chronic ischemic cardiomyopathy.
Circulation Jul, 2013 | Pubmed ID: 23757309
Cardiac myocyte-specific transgenic ecSOD targets mitochondria to protect against Ca(2+) induced permeability transition.
Frontiers in physiology , 2013 | Pubmed ID: 24194719
The NHLBI-sponsored Consortium for preclinicAl assESsment of cARdioprotective therapies (CAESAR): a new paradigm for rigorous, accurate, and reproducible evaluation of putative infarct-sparing interventions in mice, rabbits, and pigs.
Circulation research Feb, 2015 | Pubmed ID: 25499773
Safety of intracoronary infusion of 20 million C-kit positive human cardiac stem cells in pigs.
PloS one , 2015 | Pubmed ID: 25905721
Effects of Intracoronary Infusion of Escalating Doses of Cardiac Stem Cells in Rats With Acute Myocardial Infarction.
Circulation. Heart failure Jul, 2015 | Pubmed ID: 25995227
Effect of the stop-flow technique on cardiac retention of c-kit positive human cardiac stem cells after intracoronary infusion in a porcine model of chronic ischemic cardiomyopathy.
Basic research in cardiology Sep, 2015 | Pubmed ID: 26150250
Long-Term Outcome of Administration of c-kit(POS) Cardiac Progenitor Cells After Acute Myocardial Infarction: Transplanted Cells Do not Become Cardiomyocytes, but Structural and Functional Improvement and Proliferation of Endogenous Cells Persist for at Least One Year.
Circulation research Apr, 2016 | Pubmed ID: 26838790
Repeated Administrations of Cardiac Progenitor Cells Are Markedly More Effective Than a Single Administration: A New Paradigm in Cell Therapy.
Circulation research Aug, 2016 | Pubmed ID: 27364016
Myocardial Reparative Properties of Cardiac Mesenchymal Cells Isolated on the Basis of Adherence.
Journal of the American College of Cardiology Apr, 2017 | Pubmed ID: 28385312
Repeated Administrations of Cardiac Progenitor Cells Are Superior to a Single Administration of an Equivalent Cumulative Dose.
Journal of the American Heart Association 02, 2018 | Pubmed ID: 29440036
Epigenetically modified cardiac mesenchymal stromal cells limit myocardial fibrosis and promote functional recovery in a model of chronic ischemic cardiomyopathy.
Basic research in cardiology 11, 2018 | Pubmed ID: 30446837
Physiological Biomimetic Culture System for Pig and Human Heart Slices.
Circulation research Aug, 2019 | Pubmed ID: 31310161
The Effect of Cardiogenic Factors on Cardiac Mesenchymal Cell Anti-Fibrogenic Paracrine Signaling and Therapeutic Performance.
Theranostics , 2020 | Pubmed ID: 32042319
Qinghui Ou*,1,
Riham R.E. Abouleisa*,1,
Xian-Liang Tang1,
Hamzah R. Juhardeen1,
Moustafa H. Meki2,
Jessica M. Miller2,
Guruprasad Giridharan2,
Ayman El-Baz2,
Roberto Bolli1,
Tamer M.A. Mohamed1,3,4,5,6
1Institute of Molecular Cardiology, Department of Medicine, University of Louisville,
2Department of Bioengineering, University of Louisville,
3Diabetes and Obesity Center, Department of Medicine, University of Louisville,
4Department of Pharmacology and Toxicology, University of Louisville,
5Institute of Cardiovascular Sciences, University of Manchester,
6Faculty of Pharmacy, Zagazig University