Michael Simons

The FGF system has a key role in regulating vascular integrity.

Endothelium as master regulator of organ development and growth.

Syndecan-4 regulates subcellular localization of mTOR Complex2 and Akt activation in a PKCalpha-dependent manner in endothelial cells.

Syndecan-4 mediates macrophage uptake of group V secretory phospholipase A2-modified LDL.

The antiangiogenic activity of rPAI-1(23) inhibits vasa vasorum and growth of atherosclerotic plaque.

Synectin-dependent regulation of arterial maturation.

VEGF and restenosis: the rest of the story.

Regulation of vascular integrity.

FRS2 via fibroblast growth factor receptor 1 is required for platelet-derived growth factor receptor beta-mediated regulation of vascular smooth muscle marker gene expression.

Endothelium-driven myocardial growth or nitric oxide at the crossroads.

Diabetic monocyte and vascular endothelial growth factor signaling impairment.

Suppression of RhoG activity is mediated by a syndecan 4-synectin-RhoGDI1 complex and is reversed by PKCalpha in a Rac1 activation pathway.

ERK1/2-Akt1 crosstalk regulates arteriogenesis in mice and zebrafish.

Micro computed tomography for vascular exploration.

VEGF receptor 2 endocytic trafficking regulates arterial morphogenesis.

Role of synectin in lymphatic development in zebrafish and frogs.

Cell communications in the heart.

Auxiliary and autonomous proteoglycan signaling networks.

Phosphorylation of VE-cadherin controls endothelial phenotypes via p120-catenin coupling and Rac1 activation.

Antiangiogenic activity of rPAI-1(23) promotes vasa vasorum regression in hypercholesterolemic mice through a plasmin-dependent mechanism.

FGF-dependent regulation of VEGF receptor 2 expression in mice.

Development and application of a multimodal contrast agent for SPECT/CT hybrid imaging.

Macrophage skewing by Phd2 haplodeficiency prevents ischaemia by inducing arteriogenesis.

Endothelial-derived angiocrine signals induce and sustain regenerative lung alveolarization.

VEGF signaling inside vascular endothelial cells and beyond.

ALK1 signaling inhibits angiogenesis by cooperating with the Notch pathway.

Syndecan 4 regulates FGFR1 signaling in endothelial cells by directing macropinocytosis.

Fibroblast growth factor signaling potentiates VE-cadherin stability at adherens junctions by regulating SHP2.

"On-target" cardiac effects of anticancer drugs: lessons from new biology.

Syndecan 4 regulation of PDK1-dependent Akt activation.

Fibroblast growth factor-2 is required for vasa vasorum plexus stability in hypercholesterolemic mice.

Profilin phosphorylation as a VEGFR effector in angiogenesis.

Endothelial nuclear factor-κB-dependent regulation of arteriogenesis and branching.

Endothelial deletion of murine Jag1 leads to valve calcification and congenital heart defects associated with Alagille syndrome.

FGF regulates TGF-β signaling and endothelial-to-mesenchymal transition via control of let-7 miRNA expression.

Endothelial ERK signaling controls lymphatic fate specification.

The syndecan-4/protein kinase Cα pathway mediates prostaglandin E2-induced extracellular regulated kinase (ERK) activation in endothelial cells and angiogenesis in vivo.

Endothelial RAF1/ERK activation regulates arterial morphogenesis.

Dll4-Notch signaling determines the formation of native arterial collateral networks and arterial function in mouse ischemia models.

Lymphatic fate determination: playing RAF with ERK.

The neuropilin 1 cytoplasmic domain is required for VEGF-A-dependent arteriogenesis.

Effects of cell grafting on coronary remodeling after myocardial infarction.

VEGFR2 trafficking: speed doesn't kill.

Endothelial cell-dependent regulation of arteriogenesis.

Physiology. Lymphatics are in my veins.

Need glucose to sprout: local metabolic control of angiogenesis.

Endothelial signaling and the molecular basis of arteriovenous malformation.

Transmembrane protein ESDN promotes endothelial VEGF signaling and regulates angiogenesis.

Angiopoietin-2 secretion by endothelial cell exosomes: regulation by the phosphatidylinositol 3-kinase (PI3K)/Akt/endothelial nitric oxide synthase (eNOS) and syndecan-4/syntenin pathways.

Divergent angiocrine signals from vascular niche balance liver regeneration and fibrosis.

Inter-cellular exchange of cellular components via VE-cadherin-dependent trans-endocytosis.

Angiocrine factors deployed by tumor vascular niche induce B cell lymphoma invasiveness and chemoresistance.

The docking protein FRS2α is a critical regulator of VEGF receptors signaling.

Receptor tyrosine kinases endocytosis in endothelium: biology and signaling.

Vasa vasorum in normal and diseased arteries.

Netrin-1 controls sympathetic arterial innervation.

PTP1b is a physiologic regulator of vascular endothelial growth factor signaling in endothelial cells.

Flow-regulated lymphatic vasculature development and signaling.

Lymphatic fate specification: an ERK-controlled transcriptional program.

Endothelial Akt1 mediates angiogenesis by phosphorylating multiple angiogenic substrates.

Chemokine-coupled β2 integrin-induced macrophage Rac2-Myosin IIA interaction regulates VEGF-A mRNA stability and arteriogenesis.

Fibroblast growth factor receptor 1 is a key inhibitor of TGFβ signaling in the endothelium.

Fox(y) regulators of VEGF receptors.

Up-regulation of thrombospondin-2 in Akt1-null mice contributes to compromised tissue repair due to abnormalities in fibroblast function.

ELAVL1 regulates alternative splicing of eIF4E transporter to promote postnatal angiogenesis.

Molecular controls of lymphatic VEGFR3 signaling.

Endothelial cell metabolism in normal and diseased vasculature.

Cardiomyopathy and Worsened Ischemic Heart Failure in SM22-α Cre-Mediated Neuropilin-1 Null Mice: Dysregulation of PGC1α and Mitochondrial Homeostasis.

Angiogenesis versus arteriogenesis: neuropilin 1 modulation of VEGF signaling.

Molecular controls of arterial morphogenesis.

When it is better to regress: dynamics of vascular pruning.

Endothelial miR-17∼92 cluster negatively regulates arteriogenesis via miRNA-19 repression of WNT signaling.

Endothelial-to-mesenchymal transition drives atherosclerosis progression.

When endothelial cells go rogue.

The expanding role of neuropilin: regulation of transforming growth factor-β and platelet-derived growth factor signaling in the vasculature.

Smooth muscle FGF/TGFβ cross talk regulates atherosclerosis progression.

Sympathetic Innervation Promotes Arterial Fate by Enhancing Endothelial ERK Activity.

Fibroblast growth factor (FGF) signaling regulates transforming growth factor beta (TGFβ)-dependent smooth muscle cell phenotype modulation.

Syndecan 4 controls lymphatic vasculature remodeling during mouse embryonic development.

Modulation of VEGF receptor 2 signaling by protein phosphatases.

The molecular basis of endothelial cell plasticity.

Post-endocytic sorting of Plexin-D1 controls signal transduction and development of axonal and vascular circuits.

FGF-dependent metabolic control of vascular development.

SUMOylation Negatively Regulates Angiogenesis by Targeting Endothelial NOTCH Signaling.

The Rab-effector protein RABEP2 regulates endosomal trafficking to mediate vascular endothelial growth factor receptor-2 (VEGFR2)-dependent signaling.

Endothelial Cell Autonomous Role of Akt1: Regulation of Vascular Tone and Ischemia-Induced Arteriogenesis.

Reprogramming the Endocardium: Trials and Tribulations.

Endothelial Metabolic Control of Lymphangiogenesis.

Recent advances in understanding lymphangiogenesis and metabolism.

Fibroblast growth factor-transforming growth factor beta dialogues, endothelial cell to mesenchymal transition, and atherosclerosis.

Lacteal junction zippering protects against diet-induced obesity.

SUMOylation of VEGFR2 regulates its intracellular trafficking and pathological angiogenesis.

Metabolic Analysis of Lymphatic Endothelial Cells.

N-terminal syndecan-2 domain selectively enhances 6-O heparan sulfate chains sulfation and promotes VEGFA-dependent neovascularization.

Publisher Correction: N-terminal syndecan-2 domain selectively enhances 6-O heparan sulfate chains sulfation and promotes VEGFA-dependent neovascularization.

Endothelial ERK1/2 signaling maintains integrity of the quiescent endothelium.

Author Correction: SUMOylation of VEGFR2 regulates its intracellular trafficking and pathological angiogenesis.

Endothelial TGF-β signalling drives vascular inflammation and atherosclerosis.

FRS2α-dependent cell fate transition during endocardial cushion morphogenesis.

Isoform-Specific Roles of ERK1 and ERK2 in Arteriogenesis.

Resilience, disease and the age of single cell science.

Smooth Muscle Cell Reprogramming in Aortic Aneurysms.

Endothelial-to-Mesenchymal Transition, Vascular Inflammation, and Atherosclerosis.

phenotype projection of endothelial ERK1/2 signaling.

The quiescent endothelium: signalling pathways regulating organ-specific endothelial normalcy.

Developmental Perspectives on Arterial Fate Specification.

Emerging roles of PLCγ1 in endothelial biology.

Role of Venous Endothelial Cells in Developmental and Pathologic Angiogenesis.

Fibroblast growth factors: the keepers of endothelial normalcy.

Identification of driver genes for critical forms of COVID-19 in a deeply phenotyped young patient cohort.

MEKK3-TGFβ crosstalk regulates inward arterial remodeling.

Endothelium-derived lactate is required for pericyte function and blood-brain barrier maintenance.

Flow goes forward and cells step backward: endothelial migration.

FGFR1 SUMOylation coordinates endothelial angiogenic signaling in angiogenesis.

BMPR1A Promotes ID2-ZEB1 Interaction to Suppress Excessive Endothelial to Mesenchymal Transition.