John B. Bruning

Human variants in the neuronal basic helix-loop-helix/Per-Arnt-Sim (bHLH/PAS) transcription factor complex NPAS4/ARNT2 disrupt function.

Macrocyclic protease inhibitors with reduced peptide character.

New insights into the evolutionary history of plant sorbitol dehydrogenase.

Pharmacological repression of PPARγ promotes osteogenesis.

Structural mechanism for signal transduction in RXR nuclear receptor heterodimers.

Review of the Structural and Dynamic Mechanisms of PPARγ Partial Agonism.

SR2067 Reveals a Unique Kinetic and Structural Signature for PPARγ Partial Agonism.

Structure of the sliding clamp from the fungal pathogen Aspergillus fumigatus (AfumPCNA) and interactions with Human p21.

Structure-Activity Relationship of 2,4-Dichloro-N-(3,5-dichloro-4-(quinolin-3-yloxy)phenyl)benzenesulfonamide (INT131) Analogs for PPARγ-Targeted Antidiabetics.

X-ray crystal structure of rivoglitazone bound to PPARγ and PPAR subtype selectivity of TZDs.

HDX reveals the conformational dynamics of DNA sequence specific VDR co-activator interactions.

Rational Design of a 3 -Helical PIP-Box Mimetic Targeting PCNA, the Human Sliding Clamp.

PPARγ in Complex with an Antagonist and Inverse Agonist: a Tumble and Trap Mechanism of the Activation Helix.

Chemical Crosslinking Mass Spectrometry Reveals the Conformational Landscape of the Activation Helix of PPARγ; a Model for Ligand-Dependent Antagonism.

Precipitant-ligand exchange technique reveals the ADP binding mode in Mycobacterium tuberculosis dethiobiotin synthetase.

Structure, Mechanism, and Inhibition of Thioredoxin Reductase.

Shooting three inflammatory targets with a single bullet: Novel multi-targeting anti-inflammatory glitazones.

Structural and Dynamic Elucidation of a Non-acid PPAR Partial Agonist: SR1988.

Obtaining Crystals of PPARγ Ligand Binding Domain Bound to Small Molecules.

Combining random microseed matrix screening and the magic triangle for the efficient structure solution of a potential lysin from bacteriophage P68.

An aldo-keto reductase with 2-keto-l-gulonate reductase activity functions in l-tartaric acid biosynthesis from vitamin C in .

d-Alanine-d-alanine ligase as a model for the activation of ATP-grasp enzymes by monovalent cations.

Nucleoside selectivity of Aspergillus fumigatus nucleoside-diphosphate kinase.

Vanishing white matter: Eukaryotic initiation factor 2B model and the impact of missense mutations.