Mark R. Cookson

Pathways to Parkinsonism.

Microarray analysis reveals induction of heat shock proteins mRNAs by the torsion dystonia protein, TorsinA.

Crystallizing ideas about Parkinson's disease.

Dominant torsinA mutations in cellular systems.

Molecules that cause or prevent Parkinson's disease.

How genetics research in Parkinson's disease is enhancing understanding of the common idiopathic forms of the disease.

Dystonia and the nuclear envelope.

Proteomic analysis reveals co-ordinated alterations in protein synthesis and degradation pathways in LRRK2 knockout mice.

Amyotrophic lateral sclerosis 2-deficiency leads to neuronal degeneration in amyotrophic lateral sclerosis through altered AMPA receptor trafficking.

Deletion at ITPR1 underlies ataxia in mice and spinocerebellar ataxia 15 in humans.

DYT16, a novel young-onset dystonia-parkinsonism disorder: identification of a segregating mutation in the stress-response protein PRKRA.

Post-transcriptional regulation of mRNA associated with DJ-1 in sporadic Parkinson disease.

Leucine-rich repeat kinase 2 mutations and Parkinson's disease: three questions.

Genome-wide association study reveals genetic risk underlying Parkinson's disease.

The Parkinson's disease associated LRRK2 exhibits weaker in vitro phosphorylation of 4E-BP compared to autophosphorylation.

Deep sequencing of coding and non-coding RNA in the CNS.

Parkinson's disease: insights from pathways.

Abundant quantitative trait loci exist for DNA methylation and gene expression in human brain.

DJ-1 acts in parallel to the PINK1/parkin pathway to control mitochondrial function and autophagy.

The role of leucine-rich repeat kinase 2 (LRRK2) in Parkinson's disease.

DJ-1 regulation of mitochondrial function and autophagy through oxidative stress.

Mitochondrial quality control and dynamics in Parkinson's disease.

Role of LRRK2 kinase dysfunction in Parkinson disease.

Is inhibition of kinase activity the only therapeutic strategy for LRRK2-associated Parkinson's disease?

Integration of GWAS SNPs and tissue specific expression profiling reveal discrete eQTLs for human traits in blood and brain.

The G2385R variant of leucine-rich repeat kinase 2 associated with Parkinson's disease is a partial loss-of-function mutation.

Parkinsonism due to mutations in PINK1, parkin, and DJ-1 and oxidative stress and mitochondrial pathways.

Cell population-specific expression analysis of human cerebellum.

Age-associated changes in gene expression in human brain and isolated neurons.

mRNA expression, splicing and editing in the embryonic and adult mouse cerebral cortex.

Age-associated miRNA alterations in skeletal muscle from rhesus monkeys reversed by caloric restriction.

Genetic comorbidities in Parkinson's disease.

Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease.

LRRK2: dropping (kinase) inhibitions and seeking an (immune) response.

Mutations in the Matrin 3 gene cause familial amyotrophic lateral sclerosis.

Post-translational decrease in respiratory chain proteins in the Polg mutator mouse brain.

Downregulation of Pink1 influences mitochondrial fusion-fission machinery and sensitizes to neurotoxins in dopaminergic cells.

Differential protein-protein interactions of LRRK1 and LRRK2 indicate roles in distinct cellular signaling pathways.

Heterogeneity of leucine-rich repeat kinase 2 mutations: genetics, mechanisms and therapeutic implications.

Lardy brains make Parkinson's disease mice worse.

Genetic variability in the regulation of gene expression in ten regions of the human brain.

Common genetic variants influence human subcortical brain structures.

Pathways to Parkinsonism Redux: convergent pathobiological mechanisms in genetics of Parkinson's disease.

Genes associated with Parkinson's disease: regulation of autophagy and beyond.

The Polg Mutator Phenotype Does Not Cause Dopaminergic Neurodegeneration in DJ-1-Deficient Mice.

ADAR2 affects mRNA coding sequence edits with only modest effects on gene expression or splicing in vivo.

The function of orthologues of the human Parkinson's disease gene LRRK2 across species: implications for disease modelling in preclinical research.

The Effects of Variants in the Parkin, PINK1, and DJ-1 Genes along with Evidence for their Pathogenicity.

Structure, function, and leucine-rich repeat kinase 2: On the importance of reproducibility in understanding Parkinson's disease.

RNA-binding proteins implicated in neurodegenerative diseases.

Novel genetic loci underlying human intracranial volume identified through genome-wide association.

The impact of fraudulent and irreproducible data to the translational research crisis - solutions and implementation.

Cellular functions of LRRK2 implicate vesicular trafficking pathways in Parkinson's disease.

LRRK2 at the interface of autophagosomes, endosomes and lysosomes.

Novel genetic loci associated with hippocampal volume.

The G2385R risk factor for Parkinson's disease enhances CHIP-dependent intracellular degradation of LRRK2.

Mechanisms of Mutant LRRK2 Neurodegeneration.

Gene Linkage and Systems Biology.

The DYT6 Dystonia Protein THAP1 Regulates Myelination within the Oligodendrocyte Lineage.

Hexokinases link DJ-1 to the PINK1/parkin pathway.

LRRK2 phosphorylates membrane-bound Rabs and is activated by GTP-bound Rab7L1 to promote recruitment to the trans-Golgi network.

Transcriptomic profiling of the human brain reveals that altered synaptic gene expression is associated with chronological aging.

The LRRK2 signalling system.

The Endosomal-Lysosomal Pathway Is Dysregulated by Expression .

Parkinson disease-associated mutations in LRRK2 cause centrosomal defects via Rab8a phosphorylation.

Comparative Protein Interaction Network Analysis Identifies Shared and Distinct Functions for the Human ROCO Proteins.

mTOR independent alteration in ULK1 Ser758 phosphorylation following chronic LRRK2 kinase inhibition.

Detection of endogenous S1292 LRRK2 autophosphorylation in mouse tissue as a readout for kinase activity.

Frequency of Loss of Function Variants in LRRK2 in Parkinson Disease.

Finding useful biomarkers for Parkinson's disease.

A comprehensive analysis of SNCA-related genetic risk in sporadic parkinson disease.

Converging pathways in neurodegeneration, from genetics to mechanisms.

Differences in Stability, Activity and Mutation Effects Between Human and Mouse Leucine-Rich Repeat Kinase 2.

Leucine-rich repeat kinase 2 controls protein kinase A activation state through phosphodiesterase 4.

The role of monogenic genes in idiopathic Parkinson's disease.

Genetic analysis of neurodegenerative diseases in a pathology cohort.

The endocytic membrane trafficking pathway plays a major role in the risk of Parkinson's disease.

Assessment of APOE in atypical parkinsonism syndromes.

LRRK2 links genetic and sporadic Parkinson's disease.

Glial phagocytic clearance in Parkinson's disease.

Proteomics; applications in familial Parkinson's disease.

The role of Rab GTPases in the pathobiology of Parkinson' disease.

Transcriptome analysis of LRRK2 knock-out microglia cells reveals alterations of inflammatory- and oxidative stress-related pathways upon treatment with α-synuclein fibrils.

DNAJC proteins and pathways to parkinsonism.

Genetic modifiers of risk and age at onset in GBA associated Parkinson's disease and Lewy body dementia.

Molecular mechanism of olesoxime-mediated neuroprotection through targeting α-synuclein interaction with mitochondrial VDAC.

Correction to: Molecular mechanism of olesoxime-mediated neuroprotection through targeting α-synuclein interaction with mitochondrial VDAC.

In Vitro CRISPR/Cas9-Directed Gene Editing to Model LRRK2 G2019S Parkinson's Disease in Common Marmosets.

APOE4 is Associated with Differential Regional Vulnerability to Bioenergetic Deficits in Aged APOE Mice.

Pathways of protein synthesis and degradation in PD pathogenesis.

The Parkinson's Disease Protein LRRK2 Interacts with the GARP Complex to Promote Retrograde Transport to the trans-Golgi Network.

Can Leucine-Rich Repeat Kinase 2 Inhibition Benefit GBA-Parkinson's Disease?

Sequential screening nominates the Parkinson's disease associated kinase LRRK2 as a regulator of Clathrin-mediated endocytosis.

Extracellular clusterin limits the uptake of α-synuclein fibrils by murine and human astrocytes.

LRRK2 mediates microglial neurotoxicity via NFATc2 in rodent models of synucleinopathies.

Divergent Effects of G2019S and R1441C LRRK2 Mutations on LRRK2 and Rab10 Phosphorylations in Mouse Tissues.

LRRK2 mediates tubulation and vesicle sorting from lysosomes.

Combined Knockout of Lrrk2 and Rab29 Does Not Result in Behavioral Abnormalities in vivo.

Genetic analysis of amyotrophic lateral sclerosis identifies contributing pathways and cell types.