Department of Biochemistry and Molecular Biology
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Post-reductionist protein science, or putting Humpty Dumpty back together again.
Nature chemical biology Nov, 2009 | Pubmed ID: 19841622
Protein folding in the cell: challenges and progress.
Current opinion in structural biology Feb, 2011 | Pubmed ID: 21112769
Determining serpin conformational distributions with single molecule fluorescence.
Methods in enzymology , 2011 | Pubmed ID: 22078542
Competition between anion binding and dimerization modulates Staphylococcus aureus phosphatidylinositol-specific phospholipase C enzymatic activity.
The Journal of biological chemistry Nov, 2012 | Pubmed ID: 23038258
Does changing the predicted dynamics of a phospholipase C alter activity and membrane binding?
Biophysical journal Jan, 2013 | Pubmed ID: 23332071
Cation-π interactions as lipid-specific anchors for phosphatidylinositol-specific phospholipase C.
Journal of the American Chemical Society Apr, 2013 | Pubmed ID: 23506313
The cation-π box is a specific phosphatidylcholine membrane targeting motif.
The Journal of biological chemistry May, 2013 | Pubmed ID: 23576432
Deciphering protein stability in cells.
Journal of molecular biology Jan, 2014 | Pubmed ID: 24112941
Collapse of a long axis: single-molecule Förster resonance energy transfer and serpin equilibrium unfolding.
Biochemistry May, 2014 | Pubmed ID: 24749911
Physicochemical properties of cells and their effects on intrinsically disordered proteins (IDPs).
Chemical reviews Jul, 2014 | Pubmed ID: 24901537
Serpin latency transition at atomic resolution.
Proceedings of the National Academy of Sciences of the United States of America Oct, 2014 | Pubmed ID: 25313058
Energy landscapes of functional proteins are inherently risky.
Nature chemical biology Nov, 2014 | Pubmed ID: 25325699
Quantifying transient interactions between Bacillus phosphatidylinositol-specific phospholipase-C and phosphatidylcholine-rich vesicles.
Journal of the American Chemical Society Jan, 2015 | Pubmed ID: 25517221
Fluorinated Aromatic Amino Acids Distinguish Cation-π Interactions from Membrane Insertion.
The Journal of biological chemistry Jul, 2015 | Pubmed ID: 26092728
Interactions of Haptoglobin with Monomeric Globin Species: Insights from Molecular Modeling and Native Electrospray Ionization Mass Spectrometry.
Biochemistry Mar, 2016 | Pubmed ID: 26937685
Recombinant broad-range phospholipase C from Listeria monocytogenes exhibits optimal activity at acidic pH.
Biochimica et biophysica acta Jun, 2016 | Pubmed ID: 26976751
A Role for Weak Electrostatic Interactions in Peripheral Membrane Protein Binding.
Biophysical journal Mar, 2016 | Pubmed ID: 27028646
Cellular folding pathway of a metastable serpin.
Proceedings of the National Academy of Sciences of the United States of America Jun, 2016 | Pubmed ID: 27222580
Expression and Purification of Active Recombinant Human Alpha-1 Antitrypsin (AAT) from Escherichia coli.
Methods in molecular biology (Clifton, N.J.) , 2017 | Pubmed ID: 28752459
The binding of activated Gα to phospholipase C-β exhibits anomalous affinity.
The Journal of biological chemistry 10, 2017 | Pubmed ID: 28842497
All-Atom Simulations Reveal How Single-Point Mutations Promote Serpin Misfolding.
Biophysical journal 05, 2018 | Pubmed ID: 29742402
Search and Subvert: Minimalist Bacterial Phosphatidylinositol-Specific Phospholipase C Enzymes.
Chemical reviews 09, 2018 | Pubmed ID: 30148347
Delayed inhibition mechanism for secondary channel factor regulation of ribosomal RNA transcription.
eLife 02, 2019 | Pubmed ID: 30720429
Interfacial Aromatics Mediating Cation-π Interactions with Choline-Containing Lipids Can Contribute as Much to Peripheral Protein Affinity for Membranes as Aromatics Inserted below the Phosphates.
The journal of physical chemistry letters Jul, 2019 | Pubmed ID: 31246477
Proper secretion of the serpin antithrombin relies strictly on thiol-dependent quality control.
The Journal of biological chemistry 12, 2019 | Pubmed ID: 31662433
Successes and challenges in simulating the folding of large proteins.
The Journal of biological chemistry 01, 2020 | Pubmed ID: 31712314
Implementing In-Cell Fast Photochemical Oxidation of Proteins in a Platform Incubator with a Movable XY Stage.
Analytical chemistry Jan, 2020 | Pubmed ID: 31860269
Heterogeneous Diffusion of Polystyrene Nanoparticles through an Alginate Matrix: The Role of Cross-linking and Particle Size.
Environmental science & technology 04, 2020 | Pubmed ID: 32182039