Deepak Shukla

Expanding the role of 3-O sulfated heparan sulfate in herpes simplex virus type-1 entry.

Cellular expression of gH confers resistance to herpes simplex virus type-1 entry.

A role for 3-O-sulfated heparan sulfate in cell fusion induced by herpes simplex virus type 1.

Characterization of heparan sulphate 3-O-sulphotransferase isoform 6 and its role in assisting the entry of herpes simplex virus type 1.

Herpes simplex virus entry receptor nectin-1 is widely expressed in the murine eye.

Spinoculation of heparan sulfate deficient cells enhances HSV-1 entry, but does not abolish the need for essential glycoproteins in viral fusion.

A role for herpesvirus entry mediator as the receptor for herpes simplex virus 1 entry into primary human trabecular meshwork cells.

A role for 3-O-sulfotransferase isoform-4 in assisting HSV-1 entry and spread.

A role for heparan sulfate 3-O-sulfotransferase isoform 2 in herpes simplex virus type 1 entry and spread.

Expression of nectin-1 in normal and herpes simplex virus type 1-infected murine brain.

Role for 3-O-sulfated heparan sulfate as the receptor for herpes simplex virus type 1 entry into primary human corneal fibroblasts.

A novel role for phagocytosis-like uptake in herpes simplex virus entry.

Soluble 3-O-sulfated heparan sulfate can trigger herpes simplex virus type 1 entry into resistant Chinese hamster ovary (CHO-K1) cells.

Viral inhibition studies on sulfated lignin, a chemically modified biopolymer and a potential mimic of heparan sulfate.

Herpes simplex virus type 2 entry into cultured human corneal fibroblasts is mediated by herpesvirus entry mediator.

Role of 3-O-sulfated heparan sulfate in virus-induced polykaryocyte formation.

Herpes simplex virus type 1 infection induces oxidative stress and the release of bioactive lipid peroxidation by-products in mouse P19N neural cell cultures.

Using a 3-O-sulfated heparin octasaccharide to inhibit the entry of herpes simplex virus type 1.

HVEM and nectin-1 are the major mediators of herpes simplex virus 1 (HSV-1) entry into human conjunctival epithelium.

Herpes simplex virus type 1 induces filopodia in differentiated P19 neural cells to facilitate viral spread.

Antiviral activity of phytochemicals: a comprehensive review.

Role of nectin-1, HVEM, and PILR-alpha in HSV-2 entry into human retinal pigment epithelial cells.

A sugar binding protein cyanovirin-N blocks herpes simplex virus type-1 entry and cell fusion.

An unusual dependence of human herpesvirus-8 glycoproteins-induced cell-to-cell fusion on heparan sulfate.

Viral entry mechanisms: cellular and viral mediators of herpes simplex virus entry.

Viral entry mechanisms: simplicity drives complexity.

Expression of herpes virus entry mediator (HVEM) in the cornea and trigeminal ganglia of normal and HSV-1 infected mice.

A role for heparan sulfate in viral surfing.

The Importance of Heparan Sulfate in Herpesvirus Infection.

In vitro antiviral activity of neem (Azardirachta indica L.) bark extract against herpes simplex virus type-1 infection.

Mediators and mechanisms of herpes simplex virus entry into ocular cells.

Phosphoinositide 3 kinase signalling may affect multiple steps during herpes simplex virus type-1 entry.

HSV-1 infection of human corneal epithelial cells: receptor-mediated entry and trends of re-infection.

Syndecan-1 and syndecan-2 play key roles in herpes simplex virus type-1 infection.

Chronic progressive deficits in neuron size, density and number in the trigeminal ganglia of mice latently infected with herpes simplex virus.

Corneal latency and transmission of herpes simplex virus-1.

Virostatic potential of micro-nano filopodia-like ZnO structures against herpes simplex virus-1.

An important role for syndecan-1 in herpes simplex virus type-1 induced cell-to-cell fusion and virus spread.

Herpes simplex virus infects most cell types in vitro: clues to its success.

Early events in herpes simplex virus lifecycle with implications for an infection of lifetime.

Stem cell marker CD271 is expressed by vasculogenic mimicry-forming uveal melanoma cells in three-dimensional cultures.

Increased axonal expression of nectin-1 in multiple sclerosis plaques.

Nonprofessional phagocytosis can facilitate herpesvirus entry into ocular cells.

A 3-O-sulfated heparan sulfate binding peptide preferentially targets herpes simplex virus 2-infected cells.

Herpes simplex epithelial and stromal keratitis: an epidemiologic update.

Role of heparan sulfate in sexually transmitted infections.

Prophylactic, therapeutic and neutralizing effects of zinc oxide tetrapod structures against herpes simplex virus type-2 infection.

Tin oxide nanowires suppress herpes simplex virus-1 entry and cell-to-cell membrane fusion.

Susceptibility of human iris stromal cells to herpes simplex virus 1 entry.

Members of 3-O-Sulfotransferases (3-OST) Family: A Valuable Tool from Zebrafish to Humans for Understanding Herpes Simplex Virus Entry.

Role of heparan sulfate in ocular diseases.

Glycoprotein targeted therapeutics: a new era of anti-herpes simplex virus-1 therapeutics.

Recent advances in vaccine development for herpes simplex virus types I and II.

Role of Filopodia in HSV-1 Entry into Zebrafish 3-O-Sulfotransferase-3-Expressing Cells.

Exploiting herpes simplex virus entry for novel therapeutics.

Inhibition of myosin light chain kinase can be targeted for the development of new therapies against herpes simplex virus type-1 infection.

An investigative peptide-acyclovir combination to control herpes simplex virus type 1 ocular infection.

Zebrafish: modeling for herpes simplex virus infections.

Zebrafish 3-O-sulfotransferase-4 generated heparan sulfate mediates HSV-1 entry and spread.

Comprehensive analysis of herpes simplex virus 1 (HSV-1) entry mediated by zebrafish 3-O-Sulfotransferase isoforms: implications for the development of a zebrafish model of HSV-1 infection.

Characterization of a proteolytically stable D-peptide that suppresses herpes simplex virus 1 infection: implications for the development of entry-based antiviral therapy.

Corneal lymphangiogenesis in herpetic stromal keratitis.

Diversity of heparan sulfate and HSV entry: basic understanding and treatment strategies.

A role for 3-O-sulfated heparan sulfate in promoting human cytomegalovirus infection in human iris cells.

Heparanase is a host enzyme required for herpes simplex virus-1 release from cells.

Extended Release of an Anti-Heparan Sulfate Peptide From a Contact Lens Suppresses Corneal Herpes Simplex Virus-1 Infection.

Filopodia and Viruses: An Analysis of Membrane Processes in Entry Mechanisms.

Cell entry mechanisms of HSV: what we have learned in recent years.

Could zinc oxide tetrapod nanoparticles be used as an effective immunotherapy against HSV-2?

Role of metal and metal oxide nanoparticles as diagnostic and therapeutic tools for highly prevalent viral infections.

Cultured corneas show dendritic spread and restrict herpes simplex virus infection that is not observed with cultured corneal cells.

Zinc oxide tetrapods inhibit herpes simplex virus infection of cultured corneas.

Genital Herpes: Insights into Sexually Transmitted Infectious Disease.

Effects of histatin-1 peptide on human corneal epithelial cells.

Viral Activation of Heparanase Drives Pathogenesis of Herpes Simplex Virus-1.

Emerging Roles of Heparanase in Viral Pathogenesis.

Targeting Herpes Simplex Virus-1 gD by a DNA Aptamer Can Be an Effective New Strategy to Curb Viral Infection.

Herpesvirus-encoded microRNAs detected in human gingiva alter host cell transcriptome and regulate viral infection.

Viral miRNAs Alter Host Cell miRNA Profiles and Modulate Innate Immune Responses.

prediction of cellular gene targets of herpesvirus encoded microRNAs.

Herpes Simplex Virus 1 Infection Promotes the Growth of a Subpopulation of Tumor Cells in Three-Dimensional Uveal Melanoma Cultures.

Host Enzymes Heparanase and Cathepsin L Promote Herpes Simplex Virus 2 Release from Cells.

Pathogenesis of herpes simplex keratitis: The host cell response and ocular surface sequelae to infection and inflammation.

Herpesviruses and MicroRNAs: New Pathogenesis Factors in Oral Infection and Disease?

Pathological processes activated by herpes simplex virus-1 (HSV-1) infection in the cornea.

CRISPR-Cas based targeting of host and viral genes as an antiviral strategy.

Drug-encapsulated carbon (DECON): A novel platform for enhanced drug delivery.

Current and Emerging Therapies for Ocular Herpes Simplex Virus Type-1 Infections.

Prior inhibition of AKT phosphorylation by BX795 can define a safer strategy to prevent herpes simplex virus-1 infection of the eye.

Heparanase-Regulated Syndecan-1 Shedding Facilitates Herpes Simplex Virus 1 Egress.

Heparanase, Heparan Sulfate and Viral Infection.

Bacterial Pigment Prodigiosin Demonstrates a Unique Antiherpesvirus Activity That Is Mediated through Inhibition of Prosurvival Signal Transducers.

Wound Healing Properties of Histatin-5 and Identification of a Functional Domain Required for Histatin-5-Induced Cell Migration.

BX795 demonstrates potent antiviral benefits against herpes simplex Virus-1 infection of human cell lines.

Heparanase, cell signaling, and viral infections.

Vaccines and Therapies in Development for SARS-CoV-2 Infections.

and Activity, Tolerability, and Mechanism of Action of BX795 as an Antiviral against Herpes Simplex Virus 2 Genital Infection.

Infection-Induced Porcine Ex Vivo Corneal Wound Model to Study the Efficacy of Herpes Simplex Virus-1 Entry and Replication Inhibitors.

Pharmaceutically Acceptable Carboxylic Acid-Terminated Polymers Show Activity and Selectivity against HSV-1 and HSV-2 and Synergy with Antiviral Drugs.

Standalone or combinatorial phenylbutyrate therapy shows excellent antiviral activity and mimics CREB3 silencing.

The 3--sulfation of heparan sulfate modulates protein binding and lyase degradation.

Dysregulation of Cell Signaling by SARS-CoV-2.

Herpes Simplex Virus Cell Entry Mechanisms: An Update.

Pathobiology and treatment of viral keratitis.

Disruption of innate defense responses by endoglycosidase HPSE promotes cell survival.

Dissociation of DNA damage sensing by endoglycosidase HPSE.

Entry receptor bias in evolutionarily distant HSV-1 clinical strains drives divergent ocular and nervous system pathologies.

Emerging Roles of Heparan Sulfate Proteoglycans in Viral Pathogenesis.

Role of Tunneling Nanotubes in Viral Infection, Neurodegenerative Disease, and Cancer.

Heparan Sulfate Binding Cationic Peptides Restrict SARS-CoV-2 Entry.

Histatin-1 is an endogenous ligand of the sigma-2 receptor.

Prophylactic treatment with BX795 blocks activation of AKT and its downstream targets to protect vaginal keratinocytes and vaginal epithelium from HSV-2 infection.

Histatin-1 Attenuates LPS-Induced Inflammatory Signaling in RAW264.7 Macrophages.

OPTN is a host intrinsic restriction factor against neuroinvasive HSV-1 infection.

COVID-19 and oral diseases: Assessing manifestations of a new pathogen in oral infections.