Department of Ophthalmology and Visual Sciences,
Department of Microbiology and Immunology
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Expanding the role of 3-O sulfated heparan sulfate in herpes simplex virus type-1 entry.
Virology Feb, 2010 | Pubmed ID: 20004926
Cellular expression of gH confers resistance to herpes simplex virus type-1 entry.
Virology Jul, 2003 | Pubmed ID: 12890617
A role for 3-O-sulfated heparan sulfate in cell fusion induced by herpes simplex virus type 1.
The Journal of general virology Apr, 2004 | Pubmed ID: 15039523
Characterization of heparan sulphate 3-O-sulphotransferase isoform 6 and its role in assisting the entry of herpes simplex virus type 1.
The Biochemical journal Jan, 2005 | Pubmed ID: 15303968
Herpes simplex virus entry receptor nectin-1 is widely expressed in the murine eye.
Current eye research Oct-Nov, 2004 | Pubmed ID: 15590476
Spinoculation of heparan sulfate deficient cells enhances HSV-1 entry, but does not abolish the need for essential glycoproteins in viral fusion.
Journal of virological methods Sep, 2005 | Pubmed ID: 15908019
A role for herpesvirus entry mediator as the receptor for herpes simplex virus 1 entry into primary human trabecular meshwork cells.
Journal of virology Oct, 2005 | Pubmed ID: 16189018
A role for 3-O-sulfotransferase isoform-4 in assisting HSV-1 entry and spread.
Biochemical and biophysical research communications Dec, 2005 | Pubmed ID: 16259945
A role for heparan sulfate 3-O-sulfotransferase isoform 2 in herpes simplex virus type 1 entry and spread.
Virology Mar, 2006 | Pubmed ID: 16336986
Expression of nectin-1 in normal and herpes simplex virus type 1-infected murine brain.
Applied immunohistochemistry & molecular morphology : AIMM / official publication of the Society for Applied Immunohistochemistry Sep, 2006 | Pubmed ID: 16932027
Role for 3-O-sulfated heparan sulfate as the receptor for herpes simplex virus type 1 entry into primary human corneal fibroblasts.
Journal of virology Sep, 2006 | Pubmed ID: 16940509
A novel role for phagocytosis-like uptake in herpes simplex virus entry.
The Journal of cell biology Sep, 2006 | Pubmed ID: 17000878
Soluble 3-O-sulfated heparan sulfate can trigger herpes simplex virus type 1 entry into resistant Chinese hamster ovary (CHO-K1) cells.
The Journal of general virology Apr, 2007 | Pubmed ID: 17374750
Viral inhibition studies on sulfated lignin, a chemically modified biopolymer and a potential mimic of heparan sulfate.
Biomacromolecules May, 2007 | Pubmed ID: 17439173
Herpes simplex virus type 2 entry into cultured human corneal fibroblasts is mediated by herpesvirus entry mediator.
The Journal of general virology Aug, 2007 | Pubmed ID: 17622611
Role of 3-O-sulfated heparan sulfate in virus-induced polykaryocyte formation.
FEBS letters Sep, 2007 | Pubmed ID: 17765228
Herpes simplex virus type 1 infection induces oxidative stress and the release of bioactive lipid peroxidation by-products in mouse P19N neural cell cultures.
Journal of neurovirology Oct, 2007 | Pubmed ID: 17994426
Using a 3-O-sulfated heparin octasaccharide to inhibit the entry of herpes simplex virus type 1.
Biochemistry May, 2008 | Pubmed ID: 18457417
HVEM and nectin-1 are the major mediators of herpes simplex virus 1 (HSV-1) entry into human conjunctival epithelium.
Investigative ophthalmology & visual science Sep, 2008 | Pubmed ID: 18502984
Herpes simplex virus type 1 induces filopodia in differentiated P19 neural cells to facilitate viral spread.
Neuroscience letters Aug, 2008 | Pubmed ID: 18554796
Antiviral activity of phytochemicals: a comprehensive review.
Mini reviews in medicinal chemistry Oct, 2008 | Pubmed ID: 18855727
Role of nectin-1, HVEM, and PILR-alpha in HSV-2 entry into human retinal pigment epithelial cells.
Investigative ophthalmology & visual science Jun, 2009 | Pubmed ID: 19234349
A sugar binding protein cyanovirin-N blocks herpes simplex virus type-1 entry and cell fusion.
Antiviral research Oct, 2009 | Pubmed ID: 19665490
An unusual dependence of human herpesvirus-8 glycoproteins-induced cell-to-cell fusion on heparan sulfate.
Biochemical and biophysical research communications Dec, 2009 | Pubmed ID: 19747451
Viral entry mechanisms: cellular and viral mediators of herpes simplex virus entry.
The FEBS journal Dec, 2009 | Pubmed ID: 19878306
Viral entry mechanisms: simplicity drives complexity.
The FEBS journal Dec, 2009 | Pubmed ID: 19878309
Expression of herpes virus entry mediator (HVEM) in the cornea and trigeminal ganglia of normal and HSV-1 infected mice.
Current eye research Oct, 2009 | Pubmed ID: 19895317
A role for heparan sulfate in viral surfing.
Biochemical and biophysical research communications Jan, 2010 | Pubmed ID: 19909728
The Importance of Heparan Sulfate in Herpesvirus Infection.
Virologica Sinica Dec, 2008 | Pubmed ID: 19956628
In vitro antiviral activity of neem (Azardirachta indica L.) bark extract against herpes simplex virus type-1 infection.
Phytotherapy research : PTR Aug, 2010 | Pubmed ID: 20041417
Mediators and mechanisms of herpes simplex virus entry into ocular cells.
Current eye research Jun, 2010 | Pubmed ID: 20465436
Phosphoinositide 3 kinase signalling may affect multiple steps during herpes simplex virus type-1 entry.
The Journal of general virology Dec, 2010 | Pubmed ID: 20810749
HSV-1 infection of human corneal epithelial cells: receptor-mediated entry and trends of re-infection.
Molecular vision , 2010 | Pubmed ID: 21139972
Syndecan-1 and syndecan-2 play key roles in herpes simplex virus type-1 infection.
The Journal of general virology Apr, 2011 | Pubmed ID: 21148276
Chronic progressive deficits in neuron size, density and number in the trigeminal ganglia of mice latently infected with herpes simplex virus.
Brain pathology (Zurich, Switzerland) Sep, 2011 | Pubmed ID: 21371157
Corneal latency and transmission of herpes simplex virus-1.
Future virology Jan, 2011 | Pubmed ID: 21436960
Virostatic potential of micro-nano filopodia-like ZnO structures against herpes simplex virus-1.
Antiviral research Nov, 2011 | Pubmed ID: 21893101
An important role for syndecan-1 in herpes simplex virus type-1 induced cell-to-cell fusion and virus spread.
PloS one , 2011 | Pubmed ID: 21957484
Herpes simplex virus infects most cell types in vitro: clues to its success.
Virology journal Oct, 2011 | Pubmed ID: 22029482
Early events in herpes simplex virus lifecycle with implications for an infection of lifetime.
The open virology journal , 2012 | Pubmed ID: 22291864
Stem cell marker CD271 is expressed by vasculogenic mimicry-forming uveal melanoma cells in three-dimensional cultures.
Molecular vision , 2012 | Pubmed ID: 22419851
Increased axonal expression of nectin-1 in multiple sclerosis plaques.
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology Apr, 2013 | Pubmed ID: 22460696
Nonprofessional phagocytosis can facilitate herpesvirus entry into ocular cells.
Clinical & developmental immunology , 2012 | Pubmed ID: 22481969
A 3-O-sulfated heparan sulfate binding peptide preferentially targets herpes simplex virus 2-infected cells.
Journal of virology Jun, 2012 | Pubmed ID: 22491462
Herpes simplex epithelial and stromal keratitis: an epidemiologic update.
Survey of ophthalmology Sep, 2012 | Pubmed ID: 22542912
Role of heparan sulfate in sexually transmitted infections.
Glycobiology Nov, 2012 | Pubmed ID: 22773448
Prophylactic, therapeutic and neutralizing effects of zinc oxide tetrapod structures against herpes simplex virus type-2 infection.
Antiviral research Dec, 2012 | Pubmed ID: 23047013
Tin oxide nanowires suppress herpes simplex virus-1 entry and cell-to-cell membrane fusion.
PloS one , 2012 | Pubmed ID: 23110193
Susceptibility of human iris stromal cells to herpes simplex virus 1 entry.
Journal of virology Apr, 2013 | Pubmed ID: 23345512
Members of 3-O-Sulfotransferases (3-OST) Family: A Valuable Tool from Zebrafish to Humans for Understanding Herpes Simplex Virus Entry.
The open virology journal , 2013 | Pubmed ID: 23358893
Role of heparan sulfate in ocular diseases.
Experimental eye research May, 2013 | Pubmed ID: 23410824
Glycoprotein targeted therapeutics: a new era of anti-herpes simplex virus-1 therapeutics.
Reviews in medical virology May, 2013 | Pubmed ID: 23440920
Recent advances in vaccine development for herpes simplex virus types I and II.
Human vaccines & immunotherapeutics Apr, 2013 | Pubmed ID: 23442925
Role of Filopodia in HSV-1 Entry into Zebrafish 3-O-Sulfotransferase-3-Expressing Cells.
The open virology journal , 2013 | Pubmed ID: 23667409
Exploiting herpes simplex virus entry for novel therapeutics.
Viruses Jun, 2013 | Pubmed ID: 23752649
Inhibition of myosin light chain kinase can be targeted for the development of new therapies against herpes simplex virus type-1 infection.
Antiviral therapy , 2014 | Pubmed ID: 23813409
An investigative peptide-acyclovir combination to control herpes simplex virus type 1 ocular infection.
Investigative ophthalmology & visual science Sep, 2013 | Pubmed ID: 23989188
Zebrafish: modeling for herpes simplex virus infections.
Zebrafish Feb, 2014 | Pubmed ID: 24266790
Zebrafish 3-O-sulfotransferase-4 generated heparan sulfate mediates HSV-1 entry and spread.
PloS one , 2014 | Pubmed ID: 24498308
Comprehensive analysis of herpes simplex virus 1 (HSV-1) entry mediated by zebrafish 3-O-Sulfotransferase isoforms: implications for the development of a zebrafish model of HSV-1 infection.
Journal of virology Nov, 2014 | Pubmed ID: 25142596
Characterization of a proteolytically stable D-peptide that suppresses herpes simplex virus 1 infection: implications for the development of entry-based antiviral therapy.
Journal of virology Feb, 2015 | Pubmed ID: 25428865
Corneal lymphangiogenesis in herpetic stromal keratitis.
Survey of ophthalmology Jan-Feb, 2015 | Pubmed ID: 25444520
Diversity of heparan sulfate and HSV entry: basic understanding and treatment strategies.
Molecules (Basel, Switzerland) , 2015 | Pubmed ID: 25665065
A role for 3-O-sulfated heparan sulfate in promoting human cytomegalovirus infection in human iris cells.
Journal of virology May, 2015 | Pubmed ID: 25717110
Heparanase is a host enzyme required for herpes simplex virus-1 release from cells.
Nature communications Apr, 2015 | Pubmed ID: 25912399
Extended Release of an Anti-Heparan Sulfate Peptide From a Contact Lens Suppresses Corneal Herpes Simplex Virus-1 Infection.
Investigative ophthalmology & visual science Jan, 2016 | Pubmed ID: 26780322
Filopodia and Viruses: An Analysis of Membrane Processes in Entry Mechanisms.
Frontiers in microbiology , 2016 | Pubmed ID: 27014223
Cell entry mechanisms of HSV: what we have learned in recent years.
Future virology Oct, 2015 | Pubmed ID: 27066105
Could zinc oxide tetrapod nanoparticles be used as an effective immunotherapy against HSV-2?
Nanomedicine (London, England) 09, 2016 | Pubmed ID: 27527812
Role of metal and metal oxide nanoparticles as diagnostic and therapeutic tools for highly prevalent viral infections.
Nanomedicine : nanotechnology, biology, and medicine 01, 2017 | Pubmed ID: 27575283
Cultured corneas show dendritic spread and restrict herpes simplex virus infection that is not observed with cultured corneal cells.
Scientific reports 02, 2017 | Pubmed ID: 28198435
Zinc oxide tetrapods inhibit herpes simplex virus infection of cultured corneas.
Molecular vision , 2017 | Pubmed ID: 28275313
Genital Herpes: Insights into Sexually Transmitted Infectious Disease.
Microbial cell (Graz, Austria) Jun, 2016 | Pubmed ID: 28357380
Effects of histatin-1 peptide on human corneal epithelial cells.
PloS one , 2017 | Pubmed ID: 28542418
Viral Activation of Heparanase Drives Pathogenesis of Herpes Simplex Virus-1.
Cell reports 07, 2017 | Pubmed ID: 28700944
Emerging Roles of Heparanase in Viral Pathogenesis.
Pathogens (Basel, Switzerland) Sep, 2017 | Pubmed ID: 28927006
Targeting Herpes Simplex Virus-1 gD by a DNA Aptamer Can Be an Effective New Strategy to Curb Viral Infection.
Molecular therapy. Nucleic acids Dec, 2017 | Pubmed ID: 29246315
Herpesvirus-encoded microRNAs detected in human gingiva alter host cell transcriptome and regulate viral infection.
Biochimica et biophysica acta. Gene regulatory mechanisms May, 2018 | Pubmed ID: 29550353
Viral miRNAs Alter Host Cell miRNA Profiles and Modulate Innate Immune Responses.
Frontiers in immunology , 2018 | Pubmed ID: 29559974
prediction of cellular gene targets of herpesvirus encoded microRNAs.
Data in brief Aug, 2018 | Pubmed ID: 29892642
Herpes Simplex Virus 1 Infection Promotes the Growth of a Subpopulation of Tumor Cells in Three-Dimensional Uveal Melanoma Cultures.
Journal of virology 10, 2018 | Pubmed ID: 30045986
Host Enzymes Heparanase and Cathepsin L Promote Herpes Simplex Virus 2 Release from Cells.
Journal of virology 12, 2018 | Pubmed ID: 30232188
Pathogenesis of herpes simplex keratitis: The host cell response and ocular surface sequelae to infection and inflammation.
The ocular surface 01, 2019 | Pubmed ID: 30317007
Herpesviruses and MicroRNAs: New Pathogenesis Factors in Oral Infection and Disease?
Frontiers in immunology , 2018 | Pubmed ID: 30319604
Pathological processes activated by herpes simplex virus-1 (HSV-1) infection in the cornea.
Cellular and molecular life sciences : CMLS Feb, 2019 | Pubmed ID: 30327839
CRISPR-Cas based targeting of host and viral genes as an antiviral strategy.
Seminars in cell & developmental biology 12, 2019 | Pubmed ID: 30953741
Drug-encapsulated carbon (DECON): A novel platform for enhanced drug delivery.
Science advances 08, 2019 | Pubmed ID: 31453334
Current and Emerging Therapies for Ocular Herpes Simplex Virus Type-1 Infections.
Microorganisms Oct, 2019 | Pubmed ID: 31658632
Prior inhibition of AKT phosphorylation by BX795 can define a safer strategy to prevent herpes simplex virus-1 infection of the eye.
The ocular surface 04, 2020 | Pubmed ID: 31770600
Heparanase-Regulated Syndecan-1 Shedding Facilitates Herpes Simplex Virus 1 Egress.
Journal of virology 02, 2020 | Pubmed ID: 31827001
Heparanase, Heparan Sulfate and Viral Infection.
Advances in experimental medicine and biology , 2020 | Pubmed ID: 32274736
Bacterial Pigment Prodigiosin Demonstrates a Unique Antiherpesvirus Activity That Is Mediated through Inhibition of Prosurvival Signal Transducers.
Journal of virology 06, 2020 | Pubmed ID: 32295926
Wound Healing Properties of Histatin-5 and Identification of a Functional Domain Required for Histatin-5-Induced Cell Migration.
Molecular therapy. Methods & clinical development Jun, 2020 | Pubmed ID: 32346548
BX795 demonstrates potent antiviral benefits against herpes simplex Virus-1 infection of human cell lines.
Antiviral research 08, 2020 | Pubmed ID: 32380150
Heparanase, cell signaling, and viral infections.
Cellular and molecular life sciences : CMLS Dec, 2020 | Pubmed ID: 32462405
Vaccines and Therapies in Development for SARS-CoV-2 Infections.
Journal of clinical medicine Jun, 2020 | Pubmed ID: 32560227
and Activity, Tolerability, and Mechanism of Action of BX795 as an Antiviral against Herpes Simplex Virus 2 Genital Infection.
Antimicrobial agents and chemotherapy 08, 2020 | Pubmed ID: 32601167
Infection-Induced Porcine Ex Vivo Corneal Wound Model to Study the Efficacy of Herpes Simplex Virus-1 Entry and Replication Inhibitors.
Methods in molecular biology (Clifton, N.J.) , 2021 | Pubmed ID: 32808270
Pharmaceutically Acceptable Carboxylic Acid-Terminated Polymers Show Activity and Selectivity against HSV-1 and HSV-2 and Synergy with Antiviral Drugs.
ACS infectious diseases 11, 2020 | Pubmed ID: 33078609
Standalone or combinatorial phenylbutyrate therapy shows excellent antiviral activity and mimics CREB3 silencing.
Science advances Dec, 2020 | Pubmed ID: 33277262
The 3--sulfation of heparan sulfate modulates protein binding and lyase degradation.
Proceedings of the National Academy of Sciences of the United States of America 01, 2021 | Pubmed ID: 33441484
Dysregulation of Cell Signaling by SARS-CoV-2.
Trends in microbiology 03, 2021 | Pubmed ID: 33451855
Herpes Simplex Virus Cell Entry Mechanisms: An Update.
Frontiers in cellular and infection microbiology , 2020 | Pubmed ID: 33537244
Pathobiology and treatment of viral keratitis.
Experimental eye research 04, 2021 | Pubmed ID: 33556334
Disruption of innate defense responses by endoglycosidase HPSE promotes cell survival.
JCI insight 04, 2021 | Pubmed ID: 33621216
Dissociation of DNA damage sensing by endoglycosidase HPSE.
iScience Mar, 2021 | Pubmed ID: 33748723
Entry receptor bias in evolutionarily distant HSV-1 clinical strains drives divergent ocular and nervous system pathologies.
The ocular surface Jul, 2021 | Pubmed ID: 33766740
Emerging Roles of Heparan Sulfate Proteoglycans in Viral Pathogenesis.
Seminars in thrombosis and hemostasis Apr, 2021 | Pubmed ID: 33851373
Role of Tunneling Nanotubes in Viral Infection, Neurodegenerative Disease, and Cancer.
Frontiers in immunology , 2021 | Pubmed ID: 34194434
Heparan Sulfate Binding Cationic Peptides Restrict SARS-CoV-2 Entry.
Pathogens (Basel, Switzerland) Jun, 2021 | Pubmed ID: 34202835
Histatin-1 is an endogenous ligand of the sigma-2 receptor.
The FEBS journal Jul, 2021 | Pubmed ID: 34233061
Prophylactic treatment with BX795 blocks activation of AKT and its downstream targets to protect vaginal keratinocytes and vaginal epithelium from HSV-2 infection.
Antiviral research Oct, 2021 | Pubmed ID: 34303747
Histatin-1 Attenuates LPS-Induced Inflammatory Signaling in RAW264.7 Macrophages.
International journal of molecular sciences Jul, 2021 | Pubmed ID: 34360629
OPTN is a host intrinsic restriction factor against neuroinvasive HSV-1 infection.
Nature communications Sep, 2021 | Pubmed ID: 34518549
COVID-19 and oral diseases: Assessing manifestations of a new pathogen in oral infections.
International reviews of immunology Sep, 2021 | Pubmed ID: 34525891
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