Department of Physiological Sciences
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Observation of transient disorder during myosin subfragment-1 binding to actin by stopped-flow fluorescence and millisecond time resolution electron cryomicroscopy: evidence that the start of the crossbridge power stroke in muscle has variable geometry.
Proceedings of the National Academy of Sciences of the United States of America Jan, 1999 | Pubmed ID: 9892656
Mechanism of regulation of phosphate dissociation from actomyosin-ADP-Pi by thin filament proteins.
Proceedings of the National Academy of Sciences of the United States of America Dec, 2002 | Pubmed ID: 12486217
The prepower stroke conformation of myosin V.
The Journal of cell biology Dec, 2002 | Pubmed ID: 12499355
Kinetic mechanism of myosinV-S1 using a new fluorescent ATP analogue.
Biochemistry Oct, 2006 | Pubmed ID: 17059220
Real-time measurement of myosin-nucleotide noncovalent complexes by electrospray ionization mass spectrometry.
Biophysical journal Aug, 2007 | Pubmed ID: 17483158
Kinetics of ADP dissociation from the trail and lead heads of actomyosin V following the power stroke.
The Journal of biological chemistry Jan, 2008 | Pubmed ID: 17965414
Smooth muscle myosin phosphorylated at single head shows sustained mechanical activity.
The Journal of biological chemistry Jun, 2008 | Pubmed ID: 18408003
Direct observation of the mechanochemical coupling in myosin Va during processive movement.
Nature Sep, 2008 | Pubmed ID: 18668042
Switch 1 mutation S217A converts myosin V into a low duty ratio motor.
The Journal of biological chemistry Jan, 2009 | Pubmed ID: 19008235
The SAH domain extends the functional length of the myosin lever.
Proceedings of the National Academy of Sciences of the United States of America Dec, 2009 | Pubmed ID: 20018767
Mechanism of regulation of native cardiac muscle thin filaments by rigor cardiac myosin-S1 and calcium.
The Journal of biological chemistry Oct, 2010 | Pubmed ID: 20696756
Regulation of actin-myosin interaction by conserved periodic sites of tropomyosin.
Proceedings of the National Academy of Sciences of the United States of America Nov, 2012 | Pubmed ID: 23091026
Coupling of two non-processive myosin 5c dimers enables processive stepping along actin filaments.
Scientific reports May, 2014 | Pubmed ID: 24809456
Modulation of thin filament activation of myosin ATP hydrolysis by N-terminal domains of cardiac myosin binding protein-C.
Biochemistry Oct, 2014 | Pubmed ID: 25265574
Omecamtiv Mecarbil modulates the kinetic and motile properties of porcine β-cardiac myosin.
Biochemistry Mar, 2015 | Pubmed ID: 25680381
C0 and C1 N-terminal Ig domains of myosin binding protein C exert different effects on thin filament activation.
Proceedings of the National Academy of Sciences of the United States of America Feb, 2016 | Pubmed ID: 26831109
Ca-induced movement of tropomyosin on native cardiac thin filaments revealed by cryoelectron microscopy.
Proceedings of the National Academy of Sciences of the United States of America 06, 2017 | Pubmed ID: 28607071
The shaker-1 mouse myosin VIIa deafness mutation results in a severely reduced rate of the ATP hydrolysis step.
The Journal of biological chemistry 01, 2018 | Pubmed ID: 29167268
Distinct sites in tropomyosin specify shared and isoform-specific regulation of myosins II and V.
Cytoskeleton (Hoboken, N.J.) 04, 2018 | Pubmed ID: 29500902
N-Terminal Domains of Cardiac Myosin Binding Protein C Cooperatively Activate the Thin Filament.
Structure (London, England : 1993) 12, 2018 | Pubmed ID: 30270174
Investigation into the mechanism of thin filament regulation by transient kinetics and equilibrium binding: Is there a conflict?
The Journal of general physiology 05, 2019 | Pubmed ID: 30824574
A cryo-EM grid preparation device for time-resolved structural studies.
IUCrJ Nov, 2019 | Pubmed ID: 31709058
Sample deposition onto cryo-EM grids: from sprays to jets and back.
Acta crystallographica. Section D, Structural biology Apr, 2020 | Pubmed ID: 32254058
Need for Speed: Examining Protein Behavior during CryoEM Grid Preparation at Different Timescales.
Structure (London, England : 1993) 11, 2020 | Pubmed ID: 32814033
High-Resolution Cryo-EM Structure of the Cardiac Actomyosin Complex.
Structure (London, England : 1993) 01, 2021 | Pubmed ID: 33065066
The structure of the native cardiac thin filament at systolic Ca levels.
Proceedings of the National Academy of Sciences of the United States of America 03, 2021 | Pubmed ID: 33753506
Interaction of the C2 Ig-like Domain of Cardiac Myosin Binding Protein-C with F-actin.
Journal of molecular biology 09, 2021 | Pubmed ID: 34329643
On-grid and in-flow mixing for time-resolved cryo-EM.
Acta crystallographica. Section D, Structural biology Oct, 2021 | Pubmed ID: 34605427
1School of Biomedical Sciences, Faculty of Biological Sciences & Astbury Centre for Structural and Molecular Biology, University of Leeds,
2School of Molecular and Cellular Biology, Faculty of Biological Sciences & Astbury Centre for Structural and Molecular Biology, University of Leeds,
3Department of Physiological Sciences, Eastern Virginia Medical School