Howard D. White

Department of Physiological Sciences, Eastern Virginia Medical School

Affiliated withEastern Virginia Medical School

Research Area

Biochemistry

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title	2021

Other Publications

Article	Year
Observation of transient disorder during myosin subfragment-1 binding to actin by stopped-flow fluorescence and millisecond time resolution electron cryomicroscopy: evidence that the start o... Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 9892656	1999
Mechanism of regulation of phosphate dissociation from actomyosin-ADP-Pi by thin filament proteins. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 12486217	2002
The prepower stroke conformation of myosin V. The Journal of cell biology\| PubMed ID: 12499355	2002
Kinetic mechanism of myosinV-S1 using a new fluorescent ATP analogue. Biochemistry\| PubMed ID: 17059220	2006
Real-time measurement of myosin-nucleotide noncovalent complexes by electrospray ionization mass spectrometry. Biophysical journal\| PubMed ID: 17483158	2007
Kinetics of ADP dissociation from the trail and lead heads of actomyosin V following the power stroke. The Journal of biological chemistry\| PubMed ID: 17965414	2008
Smooth muscle myosin phosphorylated at single head shows sustained mechanical activity. The Journal of biological chemistry\| PubMed ID: 18408003	2008
Direct observation of the mechanochemical coupling in myosin Va during processive movement. Nature\| PubMed ID: 18668042	2008
Switch 1 mutation S217A converts myosin V into a low duty ratio motor. The Journal of biological chemistry\| PubMed ID: 19008235	2009
The SAH domain extends the functional length of the myosin lever. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20018767	2009
Mechanism of regulation of native cardiac muscle thin filaments by rigor cardiac myosin-S1 and calcium. The Journal of biological chemistry\| PubMed ID: 20696756	2010
Regulation of actin-myosin interaction by conserved periodic sites of tropomyosin. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 23091026	2012
Coupling of two non-processive myosin 5c dimers enables processive stepping along actin filaments. Scientific reports\| PubMed ID: 24809456	2014
Modulation of thin filament activation of myosin ATP hydrolysis by N-terminal domains of cardiac myosin binding protein-C. Biochemistry\| PubMed ID: 25265574	2014
Omecamtiv Mecarbil modulates the kinetic and motile properties of porcine β-cardiac myosin. Biochemistry\| PubMed ID: 25680381	2015
C0 and C1 N-terminal Ig domains of myosin binding protein C exert different effects on thin filament activation. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 26831109	2016
Ca-induced movement of tropomyosin on native cardiac thin filaments revealed by cryoelectron microscopy. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 28607071	2017
The shaker-1 mouse myosin VIIa deafness mutation results in a severely reduced rate of the ATP hydrolysis step. The Journal of biological chemistry\| PubMed ID: 29167268	2018
Distinct sites in tropomyosin specify shared and isoform-specific regulation of myosins II and V. Cytoskeleton (Hoboken, N.J.)\| PubMed ID: 29500902	2018
N-Terminal Domains of Cardiac Myosin Binding Protein C Cooperatively Activate the Thin Filament. Structure (London, England : 1993)\| PubMed ID: 30270174	2018
Investigation into the mechanism of thin filament regulation by transient kinetics and equilibrium binding: Is there a conflict? The Journal of general physiology\| PubMed ID: 30824574	2019
A cryo-EM grid preparation device for time-resolved structural studies. IUCrJ\| PubMed ID: 31709058	2019
Sample deposition onto cryo-EM grids: from sprays to jets and back. Acta crystallographica. Section D, Structural biology\| PubMed ID: 32254058	2020
Need for Speed: Examining Protein Behavior during CryoEM Grid Preparation at Different Timescales. Structure (London, England : 1993)\| PubMed ID: 32814033	2020
High-Resolution Cryo-EM Structure of the Cardiac Actomyosin Complex. Structure (London, England : 1993)\| PubMed ID: 33065066	2021
The structure of the native cardiac thin filament at systolic Ca levels. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 33753506	2021
Interaction of the C2 Ig-like Domain of Cardiac Myosin Binding Protein-C with F-actin. Journal of molecular biology\| PubMed ID: 34329643	2021
On-grid and in-flow mixing for time-resolved cryo-EM. Acta crystallographica. Section D, Structural biology\| PubMed ID: 34605427	2021